Increased Cell Wall Teichoic Acid Production and D-alanylation Are Common Phenotypes among Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) Clinical Isolates

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Bertsche, Ute; Yang, Soo-Jin; Kuehner, Daniel; Wanner, Stefanie; N. Mishra, Nagendra; Roth, Tobias; Nega, Mulugeta; Schneider, Alexander; Mayer, Christoph; Grau, Timo; S. Bayer, Arnold; Weidenmaier, Christopher;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0067398
  • Subject: Biological Sciences | teichoic | d-alanylation | phenotypes | daptomycin-resistant | methicillin-resistant | isolates

<div><p>Multiple mechanisms have been correlated with daptomycin-resistance (<b>DAP-R</b>) in <i>Staphylococcus aureus</i>. However, one common phenotype observed in many DAP-R S<i>. Aureus</i> strains is a thickened cell wall (CW). The first evidence for an impact of C... View more
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