Genetic Diversity and Lack of Artemisinin Selection Signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion

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Miao, Miao ; Wang, Zenglei ; Yang, Zhaoqing ; Yuan, Lili ; M. Parker, Daniel ; Putaporntip, Chaturong ; Jongwutiwes, Somchai ; Xangsayarath, Phonepadith ; Pongvongsa, Tiengkham ; Moji, Hazuhiko ; Dinh Tuong, Trinh ; Abe, Tomoko ; Nakazawa, Shusuke ; Phone Kyaw, Myat ; Yan, Guiyun ; Sirichaisinthop, Jeeraphat ; Sattabongkot, Jetsumon ; Mu, Jianbing ; Su, Xin-zhuan ; Kaneko, Osamu ; Cui, Liwang
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0059192
  • Subject: Microbiology | Genetics | Evolutionary Biology | Biological Sciences | artemisinin | atp6 | mekong
    • FOR: 110309 Infectious Diseases

<div><p>The recent detection of clinical Artemisinin (ART) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern. The mechanism of ART resistance is not clear; but the <i>P. falciparum</i> sarco/endoplasmic ret... View more
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