Reversible Block of Mouse Neural Stem Cell Differentiation in the Absence of Dicer and MicroRNAs

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Andersson, Therese ; Rahman, Sabhi ; N. Sansom, Stephen ; M. Alsiö, Jessica ; Kaneda, Masahiro ; Smith, James ; O'Carroll, Donal ; Tarakhovsky, Alexander ; J. Livesey, Frederick
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0013453
  • Subject: Cell Biology | differentiation | micrornas | neural | Developmental Biology | reversible | dicer
    mesheuropmc: food and beverages | genetic processes | enzymes and coenzymes (carbohydrates) | fungi

<div><h3>Background</h3><p>To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked... View more
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