Granulocyte Colony Stimulating Factor Induces Lipopolysaccharide (LPS) Sensitization via Upregulation of LPS Binding Protein in Rat

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Fang, Haoshu; Liu, Anding; Sun, Jian; Kitz, Alexandra; Dirsch, Olaf; Dahmen, Uta;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0056654
  • Subject: Chemistry | rat | Microbiology | binding | lps | granulocyte | stimulating | upregulation | sensitization | lipopolysaccharide | Immunology
    mesheuropmc: pathological conditions, signs and symptoms | lipids (amino acids, peptides, and proteins) | population characteristics | nervous system diseases | body regions

<div><p>Liver is the main organ for lipopolysaccharide (LPS) clearance. Sensitization to LPS is associated with the upregulation of LPS-binding protein (LBP) in animal models. Therefore, we hypothesized that LBP could induce LPS sensitization through enhancing hepatic u... View more
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