The systematic review requires a strict methodology and the best practice is to create and register a protocol, since the systematic review with design and compliance with the protocol has better quality and has less risk for reporting bias. Protocols include the research question, team members, search strategy, databases to search, inclusion and exclusion criteria, quality assessment tool, data extraction template, software, and more. Thereby, the systematic review developed by the CAMIN team “Effectiveness of hybrid robotic rehabilitation system on upper limb recovery of people with central injuries: a systematic review with meta-analysis” created a protocol and published it in the International Prospective Register of Systematic Reviews - PROSPERO an international database of prospectively registered systematic reviews in health and social care. PROSPERO aims to provide a comprehensive listing of systematic reviews registered at inception, to help to avoid unplanned duplication, and to provide transparency in the review process to minimize reporting bias by enabling comparison of the completed review with what was planned in the protocol. Registration in PROSPERO involves the submission and publication of key information about the design and conduct of a systematic review. Key features from the review protocol are recorded and maintained as a permanent record in PROSPERO and records are published on an open-access electronic database. This online database is produced by Centre for Reviews and Dissemination (CRD) at the University of York in England and funded by the National Institute for Health Research (NIHR).; Previous studies indicate that hybrid robotic rehabilitation systems (HRRS) may be more effective in improving motor control and functional skills compared to robotic therapy alone in patients with hemiparesis after chronic stroke and compared to traditional physical therapy in individuals with acute stroke. However, although studies prove the potential benefit of this technology, few randomized controlled trials have been conducted so far and no systematic literature review has been carried out. Systematic reviews are necessary because it is the most appropriate and current method for summarizing and synthesizing evidences about the effectiveness and effects of interventions. Therefore, this project investigates systematically the effects of HRRS on central injuries upper limb recovery based on each of the International Classification of Functioning, Disability and Health (ICF) domains. This study contributes to the development of new hybrid neuroprostheses that are proven to be effective for upper limb rehabilitation.This systematic review is done with the participation of physicians, occupational therapists and engineers.