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Other ORP type . 2021

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Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism

Name: Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism
Keywords: Quirópteros / virologia, Quirópteros / anatomia & histologia, Paramyxoviridae / isolamento & purificação

appsOther research productkeyboard_double_arrow_right Other ORP type 30 Aug 2021 English Publisher:Elsevier BV

Authors: Souza, William Marciel de; Fumagalli, Marcilio Jorge; Carrera, Jean Paul; Araújo, Jansen de; Cardoso, Jedson Ferreira; Carvalho, Cristiano de; Durigon, Edison Luiz; +4 Authors

Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism

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Abstract

Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Microchiroptera suborder) in Brazil. We discovered and characterized three novel paramyxoviruses in the kidney tissues of apparently healthy common vampire bats (D. rotundus) and Seba's short-tailed bats (C. perspicillata), which we tentatively named Kanhgág virus (KANV), Boe virus (BOEV), and Guató virus (GUATV). In this study, we classified these viruses as putative species into the Macrojêvirus genus, a newly proposed genus of the Orthoparamyxovirinae subfamily. Using RT-PCR, we detected these viruses in 20.9% (9 out of 43) of bats tested, and viral RNA was detected exclusively in kidney tissues. Attempts to isolate infectious virus were successful for KANV and GUATV. Our results expand the viral diversity, host range, and geographical distribution of the paramyxoviruses.

This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo , Brazil (Grant number. 13/14929-1 , and Scholarships No. 06/00572-0 , 15/05778-5 ; 17/13981-0 , 19/24251-9 and 18/09383-3 ) and by the CADDE/FAPESP Brazil-UK partnership grant ( MR/S0195/1 and FAPESP 18/14389-0 ) ( http://caddecentre.org/ ). NRF is supported by a Wellcome Trust and Royal Society Sir Henry Dale Fellowship ( 204311/Z/16/Z ). PRM is supported by the Medical Research Council of the United Kingdom ( MC_UU_12014/9 ). National Institutes of Health grant R24 AI120942 .

University of Texas Medical Branch. World Reference Center for Emerging Viruses and Arboviruses and Department of Microbiology and Immunology. Galveston, TX, USA / University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.

University of Oxford. Department of Zoology. Oxford, UK / Gorgas Memorial Institute of Health Studies. Department of Research in Virology and Biotechnology. Panama City, Panama.

University of Oxford. Department of Zoology. Oxford, UK / Imperial College London. Department of Infectious Disease Epidemiology. London, UK.

University of São Paulo. Ribeirão Preto Medical School. Virology Research Center. Ribeirão Preto, SP, Brazil.

Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.

University of São Paulo, São Paulo. Institute of Biomedical Sciences. São Paulo, SP, Brazil.

São Paulo State University. Faculty of Veterinary Medicine. Araçatuba, SP, Brazil.

University of São Paulo. Institute of Biomedical Sciences. São Paulo, SP, Brazil.

Keywords

Quirópteros / virologia, Quirópteros / anatomia & histologia, Paramyxoviridae / isolamento & purificação

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