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Other research product . Other ORP type . 2017

The MHC locus and genetic susceptibility to autoimmune and infectious diseases

Matzaraki, Vasiliki; Kumar, Vinod; Wijmenga, Cisca; Zhernakova, Alexandra;
Open Access
English
Published: 27 Apr 2017
Country: Netherlands
Abstract

In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases. Recent advances, including large genetic screens, imputation, and analyses of non-additive and epistatic effects, have contributed to a better understanding of the shared and specific roles of MHC variants in different diseases. We review these advances and discuss the relationships between MHC variants involved in autoimmune and infectious diseases. Further work in this area will help to distinguish between alternative hypotheses for the role of pathogens in autoimmune disease development.

Subjects

GENOME-WIDE ASSOCIATION, CHRONIC HEPATITIS-B, MAJOR HISTOCOMPATIBILITY COMPLEX, SYSTEMIC-LUPUS-ERYTHEMATOSUS, C VIRUS-INFECTION, IMMUNOGLOBULIN-LIKE RECEPTORS, INFLAMMATORY-BOWEL-DISEASE, AMINO-ACID POSITIONS, HL-A ANTIGENS, RHEUMATOID-ARTHRITIS

Related Organizations
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Funded by
EC| TANDEM
Project
TANDEM
Concurrent Tuberculosis and Diabetes Mellitus; unraveling the causal link, and improving care
  • Funder: European Commission (EC)
  • Project Code: 305279
  • Funding stream: FP7 | SP1 | HEALTH
,
EC| CD-LINK
Project
CD-LINK
Celiac disease: from lincRNAs to disease mechanism
  • Funder: European Commission (EC)
  • Project Code: 322698
  • Funding stream: FP7 | SP2 | ERC
,
WT
Project
  • Funder: Wellcome Trust (WT)
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Other ORP type . 2017
Providers: NARCIS
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