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Other research product . Other ORP type . 2018

Synthetic immune niches for cancer immunotherapy

Weiden, J.; Tel, J.; Figdor, C.G.;
Open Access
Published: 01 Mar 2018
Cancer immunotherapy can successfully promote long-term anticancer immune responses, although there is still only a limited number of patients who benefit from such treatment, and it can sometimes have severe treatment-associated adverse events. Compared with systemic immunomodulation, local immunomodulation may enable more effective treatment at lower doses and, at the same time, prevent systemic toxicity. Local delivery of engineered three-dimensional scaffolds may fulfil this role by acting as synthetic immune niches that boost anticancer immunity. In this Opinion article, we highlight the potential of scaffold-based adoptive cell transfer and scaffold-based cancer vaccines that, although applied locally, can promote systemic antitumour immunity. Furthermore, we discuss how scaffold-based cancer immunotherapy may contribute to the development of the next generation of cancer treatments.

Journal Article, Review, SDG 3 - Good Health and Well-being

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Funded by
Mimicking pathogens; an integrated nano-medicine approach to developing intelligent cancer vaccines.
  • Funder: European Commission (EC)
  • Project Code: 269019
  • Funding stream: FP7 | SP2 | ERC
NWO| The Institute for Chemical Immunology ICI
  • Funder: Netherlands Organisation for Scientific Research (NWO) (NWO)
  • Project Code: 2300181608
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Other ORP type . 2018
Providers: NARCIS