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Other research product . Other ORP type . 2017

Targeting transcription factor lysine acetylation in inflammatory airway diseases

van den Bosch, Thea; Kwiatkowski, Marcel; Bischoff, Rainer; Dekker, Frank J;
Open Access
English
Published: 01 Jul 2017
Abstract
Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlying mechanisms that may explain these effects. In previous studies, effects of HDAC inhibitors on histone acetylation are often correlated with their effects on gene expression. However, effects of HDAC inhibitors on transcription factors and their acetylation status may be particularly important in explaining these effects. These effects are also cell type-specific. Recent developments (including chemoproteomics and acetylomics) allow for a more detailed understanding of the selectivity of HDAC inhibitors, which will drive their further development into applications in inflammatory airway diseases.
Subjects

acetylation, acetylomics, asthma, chemoproteomics, COPD, histone deacetylase, inhibitor, selectivity, HISTONE DEACETYLASE INHIBITORS, NF-KAPPA-B, OBSTRUCTIVE PULMONARY-DISEASE, REGULATORY T-CELLS, SELECTIVE HDAC INHIBITORS, SEVERE ASTHMA, HISTONE/PROTEIN DEACETYLASES, INHALED CORTICOSTEROIDS, DEPENDENT TRANSCRIPTION, RESPONSE ELEMENTS

Related Organizations
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Funded by
EC| FWGDEKKER
Project
FWGDEKKER
Novel tools to read and write the epigenetic code in inflammation
  • Funder: European Commission (EC)
  • Project Code: 309782
  • Funding stream: FP7 | SP2 | ERC
,
NWO| Expanding the molecular toolbox in anti-inflammatory drug discovery
Project
  • Funder: Netherlands Organisation for Scientific Research (NWO) (NWO)
  • Project Code: 2300172468
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Other ORP type . 2017
Providers: NARCIS
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