Other research product . Other ORP type . 2017

Targeting transcription factor lysine acetylation in inflammatory airway diseases

Name: Targeting transcription factor lysine acetylation in inflammatory airway diseases
Keywords: acetylation, acetylomics, asthma, chemoproteomics, COPD, histone deacetylase, inhibitor, selectivity, HISTONE DEACETYLASE INHIBITORS, NF-KAPPA-B

van den Bosch, Thea; Kwiatkowski, Marcel; Bischoff, Rainer; Dekker, Frank J;

Open Access

English

Published: 01 Jul 2017

- Summary
- References
  (34)

Abstract

Asthma and chronic obstructive pulmonary disease are inflammatory airway diseases for which alternative therapeutic strategies are urgently needed. Interestingly, HDAC inhibitors show anti-inflammatory effects in mouse models for these diseases. Here we explore underlying mechanisms that may explain these effects. In previous studies, effects of HDAC inhibitors on histone acetylation are often correlated with their effects on gene expression. However, effects of HDAC inhibitors on transcription factors and their acetylation status may be particularly important in explaining these effects. These effects are also cell type-specific. Recent developments (including chemoproteomics and acetylomics) allow for a more detailed understanding of the selectivity of HDAC inhibitors, which will drive their further development into applications in inflammatory airway diseases.

Subjects

acetylation, acetylomics, asthma, chemoproteomics, COPD, histone deacetylase, inhibitor, selectivity, HISTONE DEACETYLASE INHIBITORS, NF-KAPPA-B, OBSTRUCTIVE PULMONARY-DISEASE, REGULATORY T-CELLS, SELECTIVE HDAC INHIBITORS, SEVERE ASTHMA, HISTONE/PROTEIN DEACETYLASES, INHALED CORTICOSTEROIDS, DEPENDENT TRANSCRIPTION, RESPONSE ELEMENTS

Related Organizations

University of Groningen
Netherlands

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Funded by

EC| FWGDEKKER, NWO| Expanding the molecular toolbox in anti-inflammatory drug discovery

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NARCIS

Other ORP type . 2017

Providers: NARCIS