Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Hindawi Publishing C...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

CIHR Canadian HIV Trials Network Coinfection and Concurrent Diseases Core Research Group: 2016 Updated Canadian HIV/Hepatitis C Adult Guidelines for Management and Treatment

Authors: Hull, Mark; Shafran, Stephen; Wong, Alex; Tseng, Alice; Giguère, Pierre; Barrett, Lisa; Haider, Shariq; +3 Authors

CIHR Canadian HIV Trials Network Coinfection and Concurrent Diseases Core Research Group: 2016 Updated Canadian HIV/Hepatitis C Adult Guidelines for Management and Treatment

Abstract

Background. Hepatitis C virus (HCV) coinfection occurs in 20–30% of Canadians living with HIV and is responsible for a heavy burden of morbidity and mortality. Purpose. To update national standards for management of HCV-HIV coinfected adults in the Canadian context with evolving evidence for and accessibility of effective and tolerable DAA therapies. The document addresses patient workup and treatment preparation, antiviral recommendations overall and in specific populations, and drug-drug interactions. Methods. A standing working group with HIV-HCV expertise was convened by The Canadian Institute of Health Research HIV Trials Network to review recently published HCV antiviral data and update Canadian HIV-HCV Coinfection Guidelines. Results. The gap in sustained virologic response between HCV monoinfection and HIV-HCV coinfection has been eliminated with newer HCV antiviral regimens. All coinfected individuals should be assessed for interferon-free, Direct Acting Antiviral HCV therapy. Regimens vary in content, duration, and success based largely on genotype. Reimbursement restrictions forcing the use of pegylated interferon is not acceptable if optimal patient care is to be provided. Discussion. Recommendations may not supersede individual clinical judgement. Treatment advances published since December 2015 are not considered in this document.

Keywords

Article Subject

271 references, page 1 of 28

Nakagawa, F., Lodwick, R. K., Smith, C. J., Smith, R., Cambiano, V., Lundgren, J. D., Delpech, V., Phillips, A. N.. Projected life expectancy of people with HIV according to timing of diagnosis. AIDS. 2012; 26 (3): 335-343

Samji, H., Cescon, A., Hogg, R. S., Modur, S. P., Althoff, K. N., Buchacz, K., Burchell, A. N., Cohen, M., Gebo, K. A., Gill, M. J., Justice, A., Kirk, G., Klein, M. B., Korthuis, P. T., Martin, J., Napravnik, S., Rourke, S. B., Sterling, T. R., Silverberg, M. J., Deeks, S., Jacobson, L. P., Bosch, R. J., Kitahata, M. M., Goedert, J. J., Moore, R., Gange, S. J.. Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada. PLoS ONE. 2013; 8 (12) [OpenAIRE]

Ly, K. N., Xing, J., Klevens, R. M., Jiles, R. B., Ward, J. W., Holmberg, S. D.. The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. Annals of Internal Medicine. 2012; 156 (4): 271-278

Klein, M. B., Rollet, K. C., Saeed, S., Cox, J., Potter, M., Cohen, J., Conway, B., Cooper, C., Côté, P., Gill, J., Haase, D., Haider, S., Harris, M., Hull, M., Moodie, E., Montaner, J., Pick, N., Rachlis, A., Rouleau, D., Wong, D., Sandre, R., Tyndall, M., Walmsley, S.. HIV and hepatitis C virus coinfection in Canada: challenges and opportunities for reducing preventable morbidity and mortality. HIV Medicine. 2013; 14 (1): 10-20

Weber, R., Sabin, C. A., Friis-Moller, N.. Liver-related deaths in persons infected with the human immunodeficiency virus the D:A:D study. Archives of Internal Medicine. 2006; 166 (15): 1632-1641

Coffin, C. S., Fung, S. K., Ma, M. M.. Management of chronic hepatitis B: Canadian Association for the Study of the Liver consensus guidelines. Canadian Journal of Gastroenterology. 2012; 26 (12): 917-938 [OpenAIRE]

Myers, R. P., Ramji, A., Bilodeau, M., Wong, S., Feld, J. J.. An update on the management of hepatitis C: consensus guidelines from the Canadian Association for the Study of the Liver. Canadian Journal of Gastroenterology. 2012; 26 (6): 359-375 [OpenAIRE]

Lima, V. D., Hogg, R. S., Harrigan, P. R., Moore, D., Yip, B., Wood, E., Montaner, J. S. G.. Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy. AIDS. 2007; 21 (6): 685-692

Hogg, R. S., Yip, B., Kully, C., Craib, K. J. P., O'Shaughnessy, M. V., Schechter, M. T., Montaner, J. S. G.. Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens. CMAJ. 1999; 160 (5): 659-665 [OpenAIRE]

Thomas, D. L.. The challenge of hepatitis C in the HIV-infected person. Annual Review of Medicine. 2008; 59: 473-485

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
    Powered byBIP!BIP!
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average