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UCPH

KOBENHAVNS UNIVERSITET
Country: Denmark
689 Projects, page 1 of 138
  • Funder: European Commission Project Code: 101025897
    Overall Budget: 328,968 EURFunder Contribution: 328,968 EUR

    I intend to investigate the representation of genocidal perpetrators in documentaries from a narratological perspective. There is a large corpus of documentaries representing perpetrators. Many feature in-depth interviews with perpetrators and are directed by victims, who in some cases spent several years filming perpetrators. Yet despite this remarkable corpus of films, surprisingly little attention has been paid to the representation of perpetrators in academic literature. ‘Representing Perpetration’ will investigate documentary filmmakers’ political and ethical narrative strategies of representing genocidal perpetrators across four different genocides: The Holocaust, the 1965–1966 Indonesian massacres, the Cambodian genocide, and the genocide of the Tutsi. I will examine the ways in which documentary filmmakers reframe the perpetrators’ self-deceptions and seek to undermine (successfully or not) the perpetrators’ accounts of history. In so doing, many of these documentary filmmakers manage to wrestle testimonies of atrocities from those most invested in concealing them. Methodologically, I will use narratology to systematically analyse directors’ depiction of genocidal perpetrators. This approach is particularly suitable to investigate the double role these documentaries play in providing an evidentiary record of perpetrators’ testimonies but also in shaping the historical narrative in accordance with the directors’ ethics.

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  • Funder: European Commission Project Code: 895141
    Overall Budget: 219,312 EURFunder Contribution: 219,312 EUR

    This project focuses on the Baum-Connes conjecture formulation for discrete quantum groups. The work of R. Meyer and R. Nest in the second half of 2000's has lead to a categorial formulation of the Baum-Connes conjecture in the context of triangulated categories. This reformulation works for both classical locally compact groups and torsion-free discrete quantum groups. Thus one of the main questions that the project aims to understand is the torsion phenomena for discrete quantum groups in relation with the categorical framework of Meyer-Nest. This will allow to manipulate conveniently the corresponding homological algebra for two main purposes. First, introducing a new insight for a proper formulation of the Baum-Connes conjecture for arbitrary discrete quantum groups. Second, carrying out explicit K-theory computations of C*-algebras defining relevant examples of quantum semi-direct products and free wreath products. The compact bicrossed product construction will be studied in detail in this framework in order to classify its torsion actions and to obtain the corresponding stability result of BC. Moreover, this construction will provide a vast class of new examples satisfying the quantum BC conjecture coming from recent constructions by several authors involving approximation properties such as property (T) or Haagerup property. The project aims also to carry out further developments in the quantum setting. One the one hand, defining and developping a quantum equivariant Künneth formula theory using the notion of Künneth functor. On the other hand, studying the recently discovered connections between compact quantum groups and non-local games, in the framework of quantum information theory, in order to address relevant open questions concerning the Connes' embedding conjecture with potential applications and consequences within the area of algorithm theory in computer science.

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  • Funder: European Commission Project Code: 863671
    Overall Budget: 1,999,970 EURFunder Contribution: 1,999,970 EUR

    IN THE SAME SEA is the first systematic investigation of the combined history of the Lesser Antilles from the 1650s to the 1850s. The project advances the hypothesis that the Lesser Antilles were decisively shaped by inter-island connections that transformed separate islands into a common world of slavery and freedom. Living in fragile societies of limited resources and marked by racial slavery, plantation production, and long-distance commerce, enslaved Africans, free people of color, and Europeans depended on and gained vital resources from crossing the short sea routes to their neighbors in English, French, Dutch, Spanish, Danish, and Swedish colonies. The project consists of a team specializing in the historiographies, archives, and languages of the six colonial powers present in the Lesser Antilles. A collaborative research methodology and digital solutions to data collection and mapping, enable the project to generate crucial new knowledge of how inter-island connections shaped the Lesser Antilles. This is done in five work packages covering the inter-island trade, enslaved movement, maintaining slavery, island belonging, and cultural responses to living in fragile societies. The project features a number of key elements designed to ensure its impact on the historical field and beyond. First, the project challenges the long-standing focus on European empires as the fundamental lodestone of the history of the Lesser Antilles. Second, it lays the foundation for an online database and digital mapping resource, which will become a crucial research tool in the fields of Caribbean and Atlantic history. Third, it brings a new analytical model to the efforts of studying spatial processes within several fields, amongst others, Atlantic history, new imperial history, and global history. Finally, the project provides vital input to the ongoing dialogues between states and institutions in the Lesser Antilles and Europe regarding the legacies of European colonialism.

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  • Funder: European Commission Project Code: 798716
    Overall Budget: 200,195 EURFunder Contribution: 200,195 EUR

    Around 90% of all cancer-related deaths are due to metastasis. Understanding the process of cancer metastasis is therefore of urgent need to develop new treatments. Aberrant expression of the epidermal growth factor receptor (EGFR), or increased availability of its ligands promote tumour survival and metastasis in multiple cancers. As a result, several anti-EGFR therapeutics are in clinical use, but almost all patients will develop resistance against the treatment. Another strategy to treat EGFR driven cancers is to reduce the pool of available EGFR ligands. The crucial enzyme in EGFR ligand release is A Disintegrin And Metalloproteinase (ADAM) 17. I have unpublished data showing that depletion of ADAM17 significantly inhibits colon cancer growth and metastasis in vivo. However, anti-ADAM17 therapies have failed clinically and thus, we urgently need to understand the regulation of ADAM17. Recent discoveries by Dr. Kveiborg’s group, and collaborators showed that the protein phosphatase PP2A binds to ADAM17, and negatively regulates EGFR ligand release, thereby representing the first known negative regulator for ADAM17. Based on these novel findings, I hypothesize that the PP2A-ADAM17-EGFR axis has the ability to control cancer metastasis. To test this hypothesis, I aim to characterize the functional impact of the PP2A-ADAM17 interaction in cancer spread by creating ADAM17 mutants with different PP2A binding properties in colon cancer cells using CRISPR/Cas9 and functionally evaluate these cells in vitro and in zebrafish and mouse models. Moreover, I aim to unravel the molecular mechanisms of the interplay; applying SILAC coupled mass spectrometry and mutagenesis screening, to evaluate the mechanism by which PP2A affects ADAM17, and the signals involved in PP2A binding. This work will pave the way for the development of novel anti-cancer drugs and thereby expand the therapeutic choices for EGFR driven cancers and improve the patient survival.

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  • Funder: European Commission Project Code: 101023584
    Overall Budget: 219,312 EURFunder Contribution: 219,312 EUR

    Prolines are unique amongst aminoacids given that they naturally exist in two isomeric states: CIS and TRANS. The transition between these states is slow but can be catalyzed by the activity of proline isomerases such as PIN1. Recent in vitro work suggests that PIN1 can alter the phosphorylation dynamics of the C-terminal domain (CTD) of RNA polymerase II (Pol II) by inhibiting phosphatase recognition. Given Pol II is solely responsible for transcribing all protein-coding genes and that CTD phosphorylation dictates the timing of RNA co-transcriptional processes, these observations suggest a crucial role for CTD proline isomerization in gene expression. Importantly, mutations in PIN1 are associated with cancer progression but a direct role for proline isomerization has remained understudied given the technical limitations imposed by its complex enzymology, such as the inability of differentiating CIS and TRANS isomers using Mass Spectrometry. In this project, I aim to functionally dissect the role of proline isomerization during Pol II transcription using rigorous biochemical, cellular and genomic techniques. Specifically, I will exploit new technological advances in peptide synthesis to permanently “lock” prolines in CIS or TRANS and identify novel isomer-specific interacting factors. I will systematically examine the consequences of CTD proline mutations and of rapid depletion of PIN1 in human cells, focusing on CTD-dependent co-transcriptional RNA processes such as splicing and poly-A–dependent 3’ termination. At the basic research level, my results will provide unprecedented resolution to the dynamics of Pol II phosphorylation, which underlies regulation of gene expression in multicellular organisms. Translationally, given that various cancers hijack the transcriptional programmes of the cell, this mechanistic understanding of CTD proline isomerization will better equip future clinical studies interested in the yet-to-be-characterized role of PIN1 in oncogenesis.

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