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ENGINEERING - INGEGNERIA INFORMATICA SPA

Country: Italy
233 Projects, page 1 of 47
  • Funder: EC Project Code: 257284
    Partners: OU, STI GMBH, ENGINEERING - INGEGNERIA INFORMATICA SPA
  • Funder: EC Project Code: 318294
    Partners: OW2, IPA, FHG, ENGINEERING - INGEGNERIA INFORMATICA SPA
  • Project . 2008 - 2010
    Funder: EC Project Code: 216967
    Partners: TIE KINETIX INFOSERVICES, ATOS SPAIN SA, THALES SERVICES, ENGINEERING - INGEGNERIA INFORMATICA SPA
  • Funder: EC Project Code: 258346
    Partners: LSE, T6ECO, Eurokleis, ENGINEERING - INGEGNERIA INFORMATICA SPA
  • Open Access mandate for Publications and Research data
    Funder: EC Project Code: 101095568
    Overall Budget: 1,780,810 EURFunder Contribution: 1,780,810 EUR
    Partners: CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY, ENGINEERING - INGEGNERIA INFORMATICA SPA, UCC, OKEY

    Five Noncommunicable Diseases (NCD) – diabetes, cardiovascular disease, cancer, chronic respiratory disease and Mental Health Disorders (MHD) – account for 86% deaths and 77% disease burden in the WHO Europe region. Of these five NCDs, MHD is unique as it has a complex bi-directional relationship with the other four major NCDs, meaning that, on one hand, it could be the initiator of the other NCDs, or other NCDs could lead to MHD which, in turn, can further aggravate the primary NCD leading to a vicious circle. Recent research identified MHD as the highest ranked NCD in adolescent population. A specific group in this population that is 3 - 6 times more vulnerable for developing MHD and subsequent NCD is the adolescents diagnosed with Autism Spectrum Disorders (ASD). There is no Evidence Based Intervention (EBI) for preventing MHD in an ASD adolescent since 1) the major risk factors are in-grained in their biological process and 2) they present with multiple MHD comorbidity. Personalisation is the key to prevent their already vulnerable mental states making transition to an MHD - "which" EBI is appropriate for "which" ASD adolescent and "how" to choose it - an unsolved question. Because of their neurobiological characteristics, personalisation must be done at biological level. Recent research showed how the environmental factors can alter gene expressions that leads to an MHD through Epigenetic-Genetic/metabolomic-Mental health (EGM) process. Using quantitative modelling of this process, ETHREAL will develop a personalised, flexible, single service delivery model that will empower an ASD adolescent to self-control their environmental factors while seamlessly accessing the community care services to prevent their mental health making transition to an MHD - a unique solution for sustainable prevention of MHD and subsequent NCDs in this population. Without loss of generality, the proposed solution could be adapted to prevent MHD in wider adolescent population.