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8,752 Projects, page 1 of 1,751
  • Funder: National Institutes of Health Project Code: 5R01MH041979-02
  • Funder: UK Research and Innovation Project Code: 1918476

    Cardiovascular disease affecting blood vessel function is a leading cause of worldwide morbidity and mortality. Vascular grafts have extensive applications in the management of such diseases. Conventional vascular graft approaches utilise autologous veins or arteries, however, it is often restricted by age, pathology or previous use. Vessels utilised in coronary artery bypass grafts experience accelerated atherosclerosis with only half remaining patent 10-years postoperatively. Identification of reliable non-autologous small diameter vascular grafts is therefore imperative. One potential solution is the bioengineered blood vessel. Numerous efforts have already been made to generate cellularised vascular grafts. However, the process of proper cell homing into the synthetic scaffold and the subsequent cell conditioning and phenotype maintenance remains obstacle for producing clinical grade vascular grafts that are comparable to native blood vessels without late stage post-implant failure. The success of the bio-engineered vessel grafts largely relies on the functionality and biocompatibility of the scaffold. The proposed project is to fabricate biodegradable vascular scaffold using natural materials with extracellular matrix and growth factors or inhibitors incorporated into the fibres for controlled release, which could promote in situ differentiation of the vascular cells from mesenchymal stem cells or induced pluripotent stem cells (iPSCs), and maintain the survival and phenotypic stability of the differentiated vascular cells.

  • Funder: National Institutes of Health Project Code: 1K23AA025920-01A1
    Funder Contribution: 187,539 USD
  • Funder: UK Research and Innovation Project Code: EP/C510410/2

    A successful transition to a low carbon economy will depend on a number of technological, economic, environmental and social factors. However, before we start this process, it is important to understand the full environmental and economic implications of any step changes that this transition may require. In this project we propose to concentrate on developing a methodology and decision-support tools that would help us understand and evaluate environmental and economic consequences of the changes required for decarbonisation of the economy. In particular, we propose to develop a methodology for a systematic life-cycle estimation of carbon inventories in different industrial sectors, including carbon footprints and embodied carbon . The project will also investigate the options for, and the associated costs of, carbon mitigation measures by considering standard economic parameters such as investment and operating costs and value added, together with uncertainty and risk where appropriate.. The intention is that the methodology and the tools will be usable for investigation of future scenarios, involving completely new technologies and products. The tools will also help companies to respond to the activities such as carbon management and emissions trading. The industrial sectors to be considered in the project include Food, Chemicals, Plastics, Construction and Biomass.

  • Funder: Fundação para a Ciência e a Tecnologia, I.P. Project Code: PRAXIS XXI/BD/4004/94

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