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Pauls Stradiņš Clinical University Hospital

Country: Latvia
3 Projects, page 1 of 1
  • Open Access mandate for Publications
    Funder: EC Project Code: 754946
    Overall Budget: 6,499,570 EURFunder Contribution: 6,499,570 EUR

    Heart attacks are common and can leave survivors suffering cardiogenic shock (CGS), with its extremely high risk of early death (42% versus 4% for non-CGS) and high incidence of chronic heart failure, with its associated socio-economic disease burden (ill-health, recurrent heart failure admissions, no return to full time activities, need for expensive therapeutic devices and life-long drugs). Outcomes from CGS are even worse in, females, the elderly (mortality>70%) and high risk sub-groups. The incidence of CGS in Europe alone is >50 000 patients pa. This unacceptably high mortality/morbidity rate represents a true unmet clinical need. No clear strategy exists to improve outcomes, with ad hoc therapies given too late in a spiralling, irrecoverable process. EURO SHOCK aims to improve outcomes for CGS patients. At its core is a robust phase3 randomised trial comparing a novel strategy of very early use of ECMO (Extracorporeal Membrane Oxygenation) to current standard of care. Evidence suggests very early ECMO will halt the spiral of decline and so significantly reduce 12 month death rate and need for heart failure re-admissions. Since both costs of CGS, and ECMO are high a health-economic cost efficacy analysis will be core. A cardiac magnetic resonance imaging sub-study will test novel protocols in sick patients and provide mechanistic data. We will test transfer networks for CGS patients and analyse ECG data to determine which patients benefit most from early transfer. Our multidisciplinary consortium comprises renowned physician-scientists, statisticians, health economists and technology providers, including specialised ECMO SME. EURO SHOCK will impact on heart attack survivors, healthcare providers and Europe`s medical technology sector by 1) reducing healthcare costs associated with CGS 2) provide novel cost effective framework for cardiac interventions 3) delivering innovative healthcare technologies and 4) informing guidelines for effective CGS intervention.

  • Open Access mandate for Publications
    Funder: EC Project Code: 101016000
    Overall Budget: 12,260,200 EURFunder Contribution: 10,497,100 EUR
    Partners: UKA, Bielefeld University, RWTH, Bethlehem Gesundheitszentrum Stolberg gemeinnützige GmbH, INT-NA, AZM, SPITALUL CLINIC DE BOLI INFECTIOASE, INFORMATION TECHNOLOGY FOR TRANSLATIONAL MEDICINE (ITTM) SA, CLINOMIC, CNR...

    The European health services have well responded to the Covid-19 emerging crisis, especially if and where the intensive care unit (ICU) capacities were sufficient, were prepared and collectively cooperating, sharing knowledge and were able to protect from further spreading of the disease among the healthcare workforce and the patients. Today, only 47% of hospitals have the recommended coverage of intensive care specialists and they are unevenly distributed between centres and periphery. The Cyber-Physical System for Telemedicine and Intensive Care (CPS4TIC) enables existing or new ICU structures to transform and operate as one ICU Hub with one central ICU and connected ICUs in peripheral hospitals. CPS4TIC was used successfully in the first wave of Covid-19 to ensure efficient and effective diagnosis and treatment of Covid-19 patients, while reducing the risk of infection drastically. The CPS4TIC consists of a telemedicine cockpit, telemedicine consoles at each peripheral hospital, a connector platform and smart bedside hubs including robotic arm at the bedsides of both, the central telemonitoring clinics and the peripheral telemonitored hospitals. The ICU hub operates telemedicine, continuous real-time telemonitoring and bedside smart care environment. The bedside smart care environment reduces the risk of infection for the health workforce significantly both for the central and the peripheral hospitals. ICU4Covid will deploy and test the CPS4TIC at large-scale, in 4+4 ICU Hubs in Europe (4 from initial consortium and 4 selected by an Open Call), involving more than 30000 patients/year with a coverage of approximately 60 Million citizens.

  • Open Access mandate for Publications
    Funder: EC Project Code: 603266
    Partners: UCD, Leipzig University, WSS, ALB FILS KLINIKEN GMBH, CVUT, AUHT, ICS, Pauls Stradiņš Clinical University Hospital, INSERM, UNICA...