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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: MARCO ANTONIO DA SILVA RAMIDAN;

    Esta dissertação, desenvolvida dentro do contexto do projeto PRONEX do Centro Geotécnico de Meio Ambiente da PUC-Rio e através de um convênio com FURNAS - PUC-Rio, apresenta uma contribuição quanto à identificação e compreensão dos mecanismos envolvidos em processos de erosão, considerando seus aspectos geológico-geotécnicos bem como medidas preventivas de reparo no caso da formação de uma voçoroca específica. A evolução do processo erosivo estudado tem suas origens na remoção mecânica de uma camada com cerca de cinco metros de solo argiloso de uma área explorada na época da construção de uma barragem de terra homogênea pertencente ao complexo Hidrelétrico de Itumbiara. Os principais aspectos da área estudada, tais como sua localização, condições climáticas e tipos de solo e vegetação foram considerados no desenvolvimento do trabalho, além de aspectos geológicos regionais e características geológico-geotécnicas da área afetada pelos processos de erosão. Tomando como base o perfil de intemperismo identificado pela inspeção das paredes da formação da voçoroca, bem como amostras de furos de sondagens SPT (ensaio de penetração normal), quatro tipos de camadas de solo foram tomados como representantes das condições do local. Objetivando-se a identificação, classificação e definição do potencial de erosão de tais materiais, espécies de amostras indeformadas de bloco (bem como as amolgadas) foram submetidas a investigações laboratoriais abrangendo: ensaio convencional de caracterização de solo; ensaio de caracterização MCT (mini-MCV); Crumb Test; ensaio de Desagregação; Pinhole Test; e Inderbitzen; ensaios de permeabilidade (também desenvolvidos em campo); análise química da água intersticial; análise mineralógica (difração de raios - X); ensaio de Resistência a Tração (sob condições de saturações diferentes) e ensaio de papel filtro (para definição das curvas características da umidade). Baseado em testes de laboratório, observações e dados de pesquisas de campo advindos de um monitoramento de poro-pressão (através de piezômetros instalados no local), mecanismos de erosão que possam predominar na área foram definidos como: micro-ravinas, ravinas e voçorocas, dentre outros. Também, ao final do trabalho, são apresentadas sugestões para remediação do local, considerando-se medidas corretivas usadas dentro do contexto da prática geotécnica convencional, e uma metodologia a ser seguida em investigações futuras relacionadas à caracterização do local e desenvolvimento de processos de erosão. This dissertation, developed within the context of the PRONEX Project of the Environmental Geotechnical Center of PUC-Rio and through a FURNAS-PUC-Rio Convenium, presents a contribution towards the identification and comprehension of mechanisms involved in erosion processes, considering its geological and geotechnical aspects as well as preventive repairing measures in the case of a specific gully formation. The evolution of the studied erosive process has its origin in the mechanical removal of some five meters of a clayey soil layer from a borrow area exploited at the time of the construction of an homogeneous embankment dam belonging to the Itumbiara Hydroelectric Complex. The main aspects of the studied area, such as its location, climatic conditions and soil and vegetation types were considered in the development of the work, besides regional geological aspects and geological-geotechnical features of the area affected by the erosion processes. Taking as a basis the unsaturated weathering profile identified by inspection of the walls of the gully formation, as well as of samples from SPT (standard penetration test) boreholes, four types of soil layers were taken as representative of site conditions. Aiming the identification, classification and definition of the erodibility potential of such materials, specimens from undisturbed block samples (as well as remolded ones) were submitted to laboratory investigations comprising: conventional soil characterization tests; MCT characterization test (mini-MCV); crumb test; desegregation test; pinhole test; Inderbitzen test, permeability tests (also performed in the field); chemical analysis (both soil and voids -water); mineralogical analysis (Xrays diffraction); tensile strength test (under different saturation conditions) and filter paper test (for definition of soil-moisture characteristic curves). Based on the results of the laboratory tests, field observations and data from pore-pressure monitoring (through piezometers installed in the site), erosion mechanisms that may prevail in the area were defined as micro-rills, rill, gully and others. Also, at the end of the work, are presented suggestions for remediation of the site, considering corrective measures used within the context of conventional geotechnical practice, and a methodology to be followed in further investigations related to the characterization of the site and development of erosion processes.

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    Authors: Enrique Colado Varela;

    [ES] A pesar de los avances en el conocimiento de la patogenia de las leucemias agudas mieloblásticas, su tratamiento especifico no ha sido modificado substancialmente en las últimas décadas y una parte importante de los enfermos presentan resistencia terapéutica primario o falleciendo de su enfermedad. Basándose en esta hipótesis, esta tesis establece la eficacia antileucémica de fármacos clásicos como Arac- C, Fludarabina y Doxorubicina, con el fin de disponer de un patrón de referencia para la ulterior comparación con nuevos fármacos en fase preclínica/experimental. A continuación investiga la eficacia y mecanismo de acción de tres fármacos en fase preclínica: el inhibidor del proteasoma Bortezomib (PS-341), el inhibidor Pan-acetilasa: Panobinostat (LBH589) y la Zalypsis, un nuevo fármaco de origen marino. Y de cada fármaco se estudiará: el efecto antitumoral y el perfil de toxicidad, el posible sinergismo de las combinaciones de estos agentes con gentes clásicos, el efecto sobre el ciclo celular y apoptosis y los cambios que inducen en el perfil de expresión génica. [EN] Despite advances in understanding the pathogenesis of acute myeloblastic leukemia, no specific treatment has been modified substantially in recent decades and an important part of primary therapy patients show resistance or died of their disease. Based on this hypothesis, this thesis establishes the antileukemic efficacy of drugs such classics as Arac-C, fludarabine and doxorubicin, in order to provide a baseline for later comparison with new drugs in preclinical / experimental. It then investigates the efficacy and mechanism of action of three drugs in preclinical phase: the proteasome inhibitor Bortezomib (PS-341), the Pan-acetylase inhibitor: Panobinostat (LBH589) and Zalypsis, a new drug of marine origin. And for each drug will be studied: the antitumor activity and toxicity profile, the possible synergism of combinations of these agents with traditional people, the effect on the cell cycle and apoptosis and inducing changes in gene expression profiling.

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    Other literature type . 2010
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sierra A Ellison;

    Supplemented by the findings of her IRB certified research project, Sierra A. Ellison delves into the positive effects pop culture and genre have on the first-year composition classroom, exploring how engaging students through a common discourse that is relatable and comfortable can aid in their writing and composition progression. She explains how teaching under a framework such as the undead and examining these types of thematic material can engage students in the material and give students the space to open up about key issues like race, sex, politics, morality, and consumerism that they might be reluctant to discuss otherwise.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    Исследование моделей трансляции знаний в так называемых практических науках в средиземноморском культурном круге XII – XIII вв.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Национальный агрегат...arrow_drop_down
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Sofie van Rongen;

    The current physical food environment, characterized by a high availability energy-dense, palatable foods, is widely held responsible for unhealthy dietary patterns. However, our understanding of how the unhealthy food environment steers unhealthy food consumption, and how this may be of particular importance for individuals with low socioeconomic status, is still limited. The aim of this thesis is to provide insights into potential psychological processes that may explain how aspects of the physical food environment and socioeconomic context may steer unhealthy food consumption. Psychological theories on contextual influences on motivational and decision-making processes are applied specifically to the food environment and food consumption. Part 1 of this thesis (Chapters 2 and 3) focuses on social norms that may be communicated by physical food environments and thereby influence consumption. In part 2 (Chapters 4 and 5), the focus is on resource scarcity and relative deprivation, which may explain how an individual’s deprived socioeconomic context stimulates unhealthier food consumption when unhealthy foods are readily available.In Chapter 2, the aim is to provide a new understanding of how micro food environments may influence consumption, by proposing that social norms are embedded in physical cues in these environments. In this photo study, in-store/restaurant food environments were analysed through a social norm lens. It was demonstrated that a great variety of physical cues in self-service food environments (e.g. food traces, covered presentation, product availability) may communicate normative messages about other consumers’ behaviour or the popularity of/demand for a product (i.e. descriptive norms) and/or the appropriateness of consumption (i.e. injunctive norms). Among a sample of laypeople, a descriptive norm concerning others’ behaviour appeared easier to recognize than an injunctive norm regarding informal rules about appropriate behaviour. Findings suggest that social norms may be inferred from a wide variety of physical cues in the outside-the-home, in-store/restaurant food context.In Chapter 3, the proposition that the physical food environment conveys social norms regarding common and appropriate consumption is examined on the level of the built, neighbourhood environment. We tested whether social norm perceptions regarding fast food consumption in the neighbourhood mediated the relationship between residential exposure to fast food outlets and fast food consumption. Fast food outlet exposure was objectively assessed as the count of fast food outlets within a 400m walking distance buffer around the postcodes of Dutch panel respondents. No direct association between residential fast food exposure and frequency of fast food consumption was found. However, both descriptive and injunctive social norms mediated the association between exposure and consumption. Those who were more exposed to fast food outlets in their direct neighbourhood perceived ‘unhealthier’ social norms, and these ‘unhealthier’ norms were in turn associated with a higher frequency of fast food consumption. Hence, this chapter provides first correlational evidence for the idea that social norms may be inferred from the built physical food environment.In Chapter 4, the aim is to experimentally examine whether experiences of resource scarcity in an absolute sense (i.e. having too few resources) result in a higher consumption of available snacks. Scarcity experiences, including trade-off making, have been proposed to lead to a decreased mental bandwidth and so more impulsive behaviour. In our studies, resource scarcity was manipulated by a self-developed trade-off task, in which participants’ resources were either restricted (scarcity condition) or unrestricted (no-scarcity condition). Two laboratory experiments were conducted among students of Wageningen University. In the first experiment, a non-hypothesized interaction effect between scarcity and hunger bordered on significance. Scarcity appeared to increase snack consumption under low, but not high, hunger levels. In the second experiment, a difference in snack consumption between the two conditions could not be replicated, although participants were explicitly instructed to have eaten prior to participation so as to reduce their level of hunger. Overall, we could not provide conclusive evidence for the notion that resource scarcity results in unhealthier food consumption. In Chapter 5, the aim is to test whether the experience of personal relative deprivation (PRD, i.e. being worse off than others) results in a higher preference for palatable, high-caloric snack-type foods. PRD has been demonstrated to increase the preference for immediate, small rewards over larger benefits in the long term. In our studies, PRD was manipulated by a computer game in which participants experienced that they earned fewer resources (PRD condition) versus equal resources (control condition) relative to an opponent. The points earned served as resources to be spent on foods in a grocery shopping task. In an online experiment, no main effect of PRD on food choice was found. However, the manipulation appeared to have a differential effect for different levels of chronic PRD. A higher number of snack-type food products was selected by participants that were relatively deprived and also experienced higher chronic relative deprivation. In a lab-in-the-field experiment, where a diverse community sample made real (non-hypothetical) food choices, it was demonstrated that those in the PRD condition selected more snack-type foods compared to those in the control condition, when particularly sensitivity to palatable food was controlled for. Although results need to be interpreted with caution, this study revealed some preliminary evidence that relative deprivation results in unhealthier food choices. Overall, findings from part 1 indicate that the real-world physical food environment may be a relevant source of social norm perceptions about what is common and appropriate food consumption. Moreover, these findings highlight the importance of human social cognition when a person is interpreting physical contexts, as they show that perceptions of social norms may be a psychological mechanism in the relation between the physical food environment and consumption. The findings in part 2 are somewhat inconclusive, but they indicate that deprivation in a relative sense through upward social comparison may result in unhealthier food choice, but that deprivation in an absolute sense does not consistently result in unhealthier food consumption. In a practical sense, this thesis suggests that social norms and PRD may be relevant psychological processes that need to be considered when the aim is to stimulate healthier consumption and reduce socioeconomic disparities in diet.

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    Other literature type . Doctoral thesis . 2021
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    Doctoral thesis . Thesis . 2021
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      Other literature type . Doctoral thesis . 2021
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  • Authors: Márcio Luiz da Silva;

    Orientador: Alessandro Batezelli Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Geociências Resumo: Integração entre métodos da sedimentologia e da paleopedologia tem auxiliado a análise paleoambiental e estudos de evolução de bacias sedimentares continentais. Solos e paleossolos refletem complexa inter-relação entre sedimentação, erosão e não-deposição, além de registrarem as condições ambientais durante seus processos evolutivos, por se constituírem sistemas abertos. Paleossolos também têm contribuído e permitido estudos mais completos de natureza estratigráfica, por indicarem estabilidade nas paisagens e descontinuidade temporal no registro sedimentar. A maioria das sucessões sedimentares que se formou em ambientes continentais é caracterizada por uma interestratificação vertical e horizontal de paleossolos e sedimentos. Estudos de interação entre paleossolos e sedimentos são valiosos instrumentos na reconstituição paleoambiental e estratigrafia de bacias sedimentares continentais, uma vez que os solos, além servirem como registros das condições ambientais, representam momentos de estabilidade da paisagem, podendo ser utilizados como proxies estratigráficos. O objetivo da presente tese foi elaborar um modelo de evolução paleoambiental do Maastrichtiano da Bacia Bauru, através do estudo da interação entre sedimentos e paleossolos, em sistemas deposicionais continentais. Foram descritas onze seções da Formação Marília (S1, S2, S3, S4, S5, S6, S7, S8, S9, S10 e S11), compreendendo quarenta e três perfis. As análises micromorfológicas, mineralógicas e geoquímicas foram feitas de acordo com a literatura especializada. Foram identificadas três litofácies principais: arentito (S), conglomerado (G) e lamito (F). Os paleossolos da Formação Marília apresentaram horizontes argílicos (Btkm, Bt, Bss) e cálcicos (Bk) com distintos graus de cimentação, constituindo-se calcretes em sua maioria. Paligorskita, quartzo e calcita foram os minerais dominantes. Pedofeições texturais de revestimentos, distribuições relativas porfíricas, quitônicas e gefúricas, associadas com fábricas birrefringentes cristalíticas, granoestriadas, poroestriadas e salpicadas foram identificadas nos paleossolos. Na Bacia Bauru, a sedimentação da Formação Marília ocorreu durante o Maastrichtiano, a partir de depósitos de sistemas fluviais dominados por rios entrelaçados. Sedimentação, erosão e pedogênese foram processos que ocorreram de forma conjunta na Formação Marília. Os ciclos deposicionais, intercalados com processos erosivos, tiveram taxas de sedimentação variando entre altas e baixas, contínuas e lentas, episódicas e rápidas e controlaram a freqüência de avulsões. Na Formação Marília, os paleossolos, exumados e soterrados, constituídos por horizontes argílicos e cálcicos, e definidos como poligenéticos, compostos e cumulativos, indicam o término de ciclos deposicionais, com taxas, intensidades e duração diferenciadas. Os paleossolos compreendem pedotipos bem drenados, moderadamente drenados, hidromórficos, indicativos de sazonalidade climática e pedotipos de condições mais secas. A Formação Marília corresponde a trato de sistemas deposicionais distributivos de clima semiárido, de baixa taxa de acomodação, dominados por depósitos de rios entrelaçados em zonas proximais a distais, depósitos de planície de inundação e depósitos eólicos limitados na porção intermediária e compreendidos por dunas sand sea isoladas. Os paleossolos, com horizontes cálcicos (Bk) e argílicos (Btk, Bt, Bss), são reflexos das paradas na sedimentação e da dinâmica de avulsão e erosão, indicando momentos de estabilidade da paisagem e das condições paleodeposicionais e sugerindo ciclicidade climática, com variação na umidificação do clima semiárido, acompanhada por mudanças na circulação hidrológica durante o Maastrichtiano da Bacia Bauru Abstract: Integration between methods of sedimentology and paleopedology has helped paleoenvironmental analysis and studies of evolution of continental sedimentary basins. Soils and paleosols reflect a complex interrelationship between sedimentation, erosion and non-deposition, in addition to registering the environmental conditions during their evolutionary processes, since they are open systems. Paleosols have also contributed and allowed more complete studies of stratigraphic nature, since they indicate stability in the landscapes and temporal discontinuity in the sedimentary record. Most of the sedimentary sequences that formed in continental environments are characterized by vertical and horizontal interstratification of paleosols and sediments. Studies of interaction between paleosols and sediments are valuable instruments in the paleoenvironmental reconstruction and stratigraphy of continental sedimentary basins, since the soils, besides serving as records of the environmental conditions, represent moments of stability of the landscape, and can be used as stratigraphic proxies. The objective of this thesis was to elaborate a paleoenvironmental evolution model of the Maastrichtian of the Bauru Basin, through the study of the interaction between sediments and paleosols, in continental depositional systems. Eleven sections of the Marília Formation (S1, S2, S3, S4, S5, S6, S7, S8, S9, S10 and S11) were described, comprising forty three profiles. The micromorphological, mineralogical and geochemical analyzes were done according to the specialized literature. Three main lithofacies were identified: sandstone (S), conglomerate (G) and mudstone (F). The paleosols of the Marília Formation presented argillic (Btkm, Bt, Bss) and calcic (Bk) horizons with different degrees of cementation, constituting calcretes in their majority. Palygorskite, quartz and calcite were the dominant minerals. Textural pedofeatures of coatings, porphyric, chitonic and gefuric c/f-related distributions, associated with crystallitic, granostriated, porostriated e speckled b-fabrics were identified in the paleosols. In the Bauru Basin, the sedimentation of the Marília Formation occurred during the Maastrichtian, from deposits of fluvial systems dominated by braided rivers. Sedimentation, erosion and pedogenesis were processes that occurred together in the Marília Formation. The depositional cycles, interspersed with erosive processes, had sedimentation rates varying between high and low, continuous and slow, episodic and quick controlled the frequency of avulsions. In the Marília Formation, paleosols, exhumed and buried, constituted by argillic and calcic horizons, and defined as polygenetic, compound and cumulative, indicate the end of depositional cycles, with differentiated rates, intensities and duration. The palaeosols comprise well drained, moderately drained, hydromorphic pedotypes, indicative of climatic seasonality and pedotypes of drier conditions. The Marília Formation corresponds to the tracts of distributive fluvial systems of semi-arid climate, low rate of accommodation, dominated by deposits of braided rivers in proximal and distal zones, floodplain deposits and eolic deposits limited in the intermediate portion and comprised of dunes isolated. The paleosols, with calcic (Bk) and argillic (Btk, Bt, Bss) horizons, are reflections of the non-sedimentation and avulsion and erosion dynamics, indicating moments of landscape stability and paleodepositional conditions and suggesting climatic cyclicity, with variation in the humidification of the semi-arid climate, accompanied by changes in the hydrological circulation during the Maastrichtian of the Bauru Basin Doutorado Geologia e Recursos Naturais Doutor em Ciências

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    Authors: Carolina Moriani Siniscalchi;

    Chresta belongs to tribe Vernonieae, subtribe Chrestinae, and presents eighteen species distributed in the Caatinga, Cerrado and Mata Atlântica domains. Its species display a fairly wide range of characters that led the species to be ascribed to several distinct genera, sometimes also classified into different groups inside the tribe. Attempts to define the position of the genus in relation to other Vernonieae subtribes and to understand the relationships within the genus have so far been unsuccessful. In this work, we present a novel phylogeny for Chresta, based on a complete set of sampled taxa from which hundreds of molecular markers were assessed, and for the first time, phylogenomics methods are applied to a Neotropical group of Asteraceae. We confirm the monophyly of Chresta and resolve infrageneric relationships with high support for all clades. We also successfully define the sister group to the genus, although the relations of this whole lineage with Lychnophorinae and Lepidaploinae are still doubtful, and. We use the obtained trees to reconstruct ancestral states of ten selected characters, which seem to have played an important role during the history of the genus, and propose a biogeographical scenario where the diversification of the group may have taken place. We also use evidence from microsatellite markers to study the population genetics of five species from the Caatinga that naturally present isolated populations restricted to narrow rupiculous habitats. These species present contrasting patterns, varying in their degree of genetic diversity and structuring, and this data enable us to discuss the relative impact of factors such as spatial distance, substrate preference, population size and dispersal ability on the genetic flow among the populations assessed. We also present an illustrated synopsis of the genus, with a new phylogenetic infrageneric classification, summarizing the accumulated knowledge about Chresta so far. We provide descriptions of four new species, a key for identification of 18 accepted species and three infrageneric taxa, synonyms, illustrations and distribution maps of the species, as well as their current conservation status Chresta pertence à tribo Vernonieae e apresenta dezoito espécies distribuídas nos domínios da Caatinga, Cerrado e Mata Atlântica. A extensa variabilidade de caracteres observada no gênero fez com que suas espécies fossem atribuídas a diversos gêneros distintos e até mesmo classificadas em diferentes grupos dentro da tribo. Tentativas anteriores de definir a posição do gênero em relação a outras subtribos de Vernonieae não foram bem-sucedidas. Nesse trabalho, apresentamos uma nova filogenia para Chresta, baseada numa amostragem taxonômica completa da qual obtivemos centenas de marcadores moleculares e, pela primeira vez, métodos filogenômicos são aplicados a um grupo neotropical de Asteraceae. Essa análise confirma a monofilia de Chresta, resolve as relações infragenéricas com alto suporte, e define com sucesso o grupo-irmão do gênero, embora as relações dessa linhagem com Lychnophorinae e Lepidaploinae ainda sejam duvidosas. Usamos as árvores obtidas para reconstruir estados ancestrais de dez caracteres morfológicos selecionados face a sua provável relevância na história do grupo, e assim propomos um cenário biogeográfico no qual a diversificação do grupo pode ter ocorrido. Também usamos marcadores de microssatélites para estudar a genética de populações de cinco espécies da Caatinga que apresentam populações naturalmente isoladas, devido a sua restrição a afloramentos rochosos de área limitada. Essas espécies apresentam diferentes padrões, variando no grau de diversidade e estruturação genética. Esses dados permitem uma discussão do impacto relativo de fatores como distância espacial, preferência de substrato, tamanho populacional e capacidade de dispersão, sobre o fluxo gênico entre as populações analisadas. Também apresentamos uma sinopse ilustrada do gênero, com uma nova classificação infra-genérica filogenética, condensando o conhecimento acumulado até o momento sobre Chresta. A sinopse inclui descrição de quatro espécies novas, chave de identificação das 18 espécies aceitas e três táxons infragenéricos, sinonímia completa, ilustrações e mapas de distribuição das espécies, bem como seu status de conservação atual

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    Главной задачей работы является создание модели использования парадигмы бихевиоризма в манипуляциях СМИ и доказательство использования выявленной модели на практике.

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    Authors: Robert Vogt-Ardatjew;

    The phenomenon of resonating electromagnetic (EM) fields has been commonly and successfully exploited in reverberation chambers (RC) for the purpose of electromagnetic compatibility (EMC) testing, as well as modeling multipath environments. Although largely successful, the currently used statistical models allow for a certain degree of freedom, especially with regard to defining the extreme field strengths, which are also the main cause of electromagnetic interference (EMI). Furthermore, some actual multipath, enclosed environments such as airplane fuselages, ships, or even building interiors, can unintentionally possess the ability to create enough strong reflections so that the resulting resonating EM field within them resembles the field inside a dedicated RC. The initial step made in this thesis focuses on introducing REs as environments sharing multiple aspects of EM field shaping with RCs. The results indicate a possible similarity to a referential RC analyzed alongside. Furthermore, due to the difficulty of collecting large amounts of data and parameter isolation in the REs, two dedicated chambers: a classical RC and the vibrating intrinsic reverberation chamber (VIRC), have been analyzed as candidates allowing to simulate an RE in laboratory conditions. The search of maximum field strengths in REs has been performed by exploiting the capability of the VIRC to efficiently generate large amounts of independent samples. Performing very long measurements in the VIRC allows to obtain the desired results with very high repeatability, while giving space for parameter isolation. The measurement results obtained outside the laboratory conditions allowed to formulate a method of performing on-site emissions testing. Although performed in imperfect REs, a modified RC standard technique has been successfully applied, concluding that such an approach is possible and recommended. The final topic of the thesis discusses a creation of a simplified macro-parameter model of field coupling to cables when neither the exact cable geometry, nor the coupling field is known. Instead of focusing on precision, this investigation aims at finding any similarities, possibly allowing to avoid the difficulties related to the very sensitive description of a non-uniform transmission line, exploiting the mixed randomness of the line geometry and the multipath field excitation.

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    Doctoral thesis . 2017
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    Doctoral thesis . Thesis . 2017
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      Doctoral thesis . 2017
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    Authors: Walter, David K.;

    In Sigriswil gibt es 562 bekannte Zweitwohnungen, was bei einem Gesamtwohnungsbestand von 3749 Wohnungen einem Zweitwohnungsanteil von 15 Prozent entspricht. Die Differenz zum Zweitwohnungsanteil gemäss ARE kann einerseits anhand des Adressenbestandes der Tourismusorganisationen, andererseits aufgrund des nicht aktuellen Gebäude- und Wohnungsregisters der Einwohnergemeinde erklärt werden. Allerdings wird vermutet, dass eine gewisse Anzahl Zweitwohnungen noch nicht als solche bekannt sind, sodass der Anteil wohl zwischen 15 und 20 Prozent liegt. Die heute bekannten Zweitwohnungen umfassen rund 2000 Betten, während die Hotels in Sigriswil 630 Betten anbieten. Im Jahr 2017 wurden 19 500 Logiernächte in Ferienwohnungen von Einheimischen, 68 600 Logiernächte in Zweitwohnungen durch deren Besitzende, 9000 Logiernächte durch vermietete Zweitwohnungen und 135 700 Logiernächte in Hotels generiert. Sigriswil verzeichnet demnach rund 230 000 touristische Logiernächte pro Jahr. Die Zweitwohnungen werden 24 Mal pro Jahr genutzt, wobei die Besitzenden und deren Familien 61 Nächte (122 Logiernächte) darin verbringen. 80 Prozent der Zweitwohnungsbesitzenden aus der Schweiz reisen mit dem Auto an und legen für die Anreise durchschnittlich rund 100 Kilometer zu-rück. Die im Ausland ansässigen Besitzenden reisen rund 2200 Kilometer zu ihrer Zweitwohnung. Die Besitzenden nutzen ihre Zweitwohnungen vorwiegend zur Erholung und für Ausflüge in der Region. Für alle Konsumausgaben geben die Besitzenden in Sigriswil jährlich 2800 CHF pro Zweitwohnung aus. Das ergibt über 1,6 Millionen CHF Wertschöpfung für lokales Gewerbe und Dienstleistungsanbietende in Sigriswil. Neben den Konsumausgaben werden jährlich 10 300 CHF in jede Zweitwohnung investiert, was in einem jährlichen Investitionsvolumen von 5,8 Millionen CHF resultiert. Zudem bezahlen Zweitwohnungsbesitzende jährlich Steuern und Gebühren von rund 1 200 CHF für ihre Zweitwohnung, was insgesamt zu Einnahmen in der Höhe von 690 000 CHF führt. Zwei Drittel der Zweitwohnungsbesitzenden haben ihre Wohnung gekauft, ein Viertel hat sie geerbt und zehn Prozent haben die Wohnung geschenkt bekommen. Die Wohnungen sind dabei durchschnitt-lich seit knapp 18 Jahren im Besitz der heutigen Besitzenden. Die Lage und Umgebung sowie die Erreichbarkeit vom Erstwohnsitz sind die wichtigsten Gründe, weshalb die Zweitwohnungsbesitzenden ihre Wohnung gekauft haben. Knapp zwei Drittel können es sich allerdings nicht vorstellen, in Sigriswil ihren Erstwohnsitz zu haben. Ebenfalls fast zwei Drittel der Zweitwohnungsbesitzenden sind älter als 65 Jahre, wobei das Durchschnittsalter bei 68 Jahren liegt. Die Besitzenden kommen zu 93 Prozent aus der Schweiz und sieben Prozent leben im Ausland. Besitzende aus Bern (45%), beider Basel (20%), Zürich (12%) und dem Ausland (7%) repräsentieren insgesamt 84 Prozent aller Zweitwohnungsbesitzenden. In Sigriswil werden 15 Prozent der Zweitwohnungen vermietet. Diese werden durchschnittlich während 54 Nächten (108 Logiernächten) pro Wohnung genutzt. Dadurch werden bei einem Durchschnittspreis von 85 CHF pro Nacht Mieteinnahmen von über 300 000 CHF generiert. Die restlichen Zweitwohnungsbesitzenden vermieten ihre Wohnung vor allem wegen dem drohenden Eingriff in die Privatsphäre sowie der eingeschränkten Flexibilität nicht. Es sind jedoch weitere 15 Prozent zur Vermietung bereit, wenn Dienstleistungen angeboten würden, welche die Vermietung vereinfachen. In diesem berechneten Szenario könnten somit über 18 000 Logiernächte und somit über 600 000 CHF an Mieteinnahmen durch Vermietung generiert werden. Zweitwohnungsbesitzende fühlen sich in Sigriswil sehr wohl und sie haben ein soziales Umfeld von 13 Personen an ihrem Zweitwohnsitz. Sowohl mit der Einwohnergemeinde und den Tourismusorganisationen als auch mit dem touristischen Angebot sind die Zweitwohnungsbesitzenden zu rund 90 Prozent sehr zufrieden oder eher zufrieden. Sie sehen auf Gemeindeebene vor allem in den Bereichen In-formation und Kommunikation, Mobilität, Gemeindedienstleistungen und Infrastruktur noch Verbesserungsmöglichkeiten. Auf Seite des Tourismus wird eine nachhaltige Entwicklung befürwortet, aber es gibt Unverständnis für die erhobene Kurtaxe und deren Verwendung. Nur gerade 10 Prozent wünschen sich eine verbesserte Einbindung in das Gemeindeleben, wobei dies vor allem durch Freiwilligenarbeit oder durch Mitsprache und das Einbringen von Know-how geschehen soll. + ID der Publikation: hslu_79064 + Art des Beitrages: Bachelorarbeit + Name der Universität / Institution inkl. Ort: Hochschule Luzern - Wirtschaft + Land der Universität / Institution: Schweiz + Sprache: Deutsch + Letzte Aktualisierung: 2020-11-12 16:23:37

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    Authors: MARCO ANTONIO DA SILVA RAMIDAN;

    Esta dissertação, desenvolvida dentro do contexto do projeto PRONEX do Centro Geotécnico de Meio Ambiente da PUC-Rio e através de um convênio com FURNAS - PUC-Rio, apresenta uma contribuição quanto à identificação e compreensão dos mecanismos envolvidos em processos de erosão, considerando seus aspectos geológico-geotécnicos bem como medidas preventivas de reparo no caso da formação de uma voçoroca específica. A evolução do processo erosivo estudado tem suas origens na remoção mecânica de uma camada com cerca de cinco metros de solo argiloso de uma área explorada na época da construção de uma barragem de terra homogênea pertencente ao complexo Hidrelétrico de Itumbiara. Os principais aspectos da área estudada, tais como sua localização, condições climáticas e tipos de solo e vegetação foram considerados no desenvolvimento do trabalho, além de aspectos geológicos regionais e características geológico-geotécnicas da área afetada pelos processos de erosão. Tomando como base o perfil de intemperismo identificado pela inspeção das paredes da formação da voçoroca, bem como amostras de furos de sondagens SPT (ensaio de penetração normal), quatro tipos de camadas de solo foram tomados como representantes das condições do local. Objetivando-se a identificação, classificação e definição do potencial de erosão de tais materiais, espécies de amostras indeformadas de bloco (bem como as amolgadas) foram submetidas a investigações laboratoriais abrangendo: ensaio convencional de caracterização de solo; ensaio de caracterização MCT (mini-MCV); Crumb Test; ensaio de Desagregação; Pinhole Test; e Inderbitzen; ensaios de permeabilidade (também desenvolvidos em campo); análise química da água intersticial; análise mineralógica (difração de raios - X); ensaio de Resistência a Tração (sob condições de saturações diferentes) e ensaio de papel filtro (para definição das curvas características da umidade). Baseado em testes de laboratório, observações e dados de pesquisas de campo advindos de um monitoramento de poro-pressão (através de piezômetros instalados no local), mecanismos de erosão que possam predominar na área foram definidos como: micro-ravinas, ravinas e voçorocas, dentre outros. Também, ao final do trabalho, são apresentadas sugestões para remediação do local, considerando-se medidas corretivas usadas dentro do contexto da prática geotécnica convencional, e uma metodologia a ser seguida em investigações futuras relacionadas à caracterização do local e desenvolvimento de processos de erosão. This dissertation, developed within the context of the PRONEX Project of the Environmental Geotechnical Center of PUC-Rio and through a FURNAS-PUC-Rio Convenium, presents a contribution towards the identification and comprehension of mechanisms involved in erosion processes, considering its geological and geotechnical aspects as well as preventive repairing measures in the case of a specific gully formation. The evolution of the studied erosive process has its origin in the mechanical removal of some five meters of a clayey soil layer from a borrow area exploited at the time of the construction of an homogeneous embankment dam belonging to the Itumbiara Hydroelectric Complex. The main aspects of the studied area, such as its location, climatic conditions and soil and vegetation types were considered in the development of the work, besides regional geological aspects and geological-geotechnical features of the area affected by the erosion processes. Taking as a basis the unsaturated weathering profile identified by inspection of the walls of the gully formation, as well as of samples from SPT (standard penetration test) boreholes, four types of soil layers were taken as representative of site conditions. Aiming the identification, classification and definition of the erodibility potential of such materials, specimens from undisturbed block samples (as well as remolded ones) were submitted to laboratory investigations comprising: conventional soil characterization tests; MCT characterization test (mini-MCV); crumb test; desegregation test; pinhole test; Inderbitzen test, permeability tests (also performed in the field); chemical analysis (both soil and voids -water); mineralogical analysis (Xrays diffraction); tensile strength test (under different saturation conditions) and filter paper test (for definition of soil-moisture characteristic curves). Based on the results of the laboratory tests, field observations and data from pore-pressure monitoring (through piezometers installed in the site), erosion mechanisms that may prevail in the area were defined as micro-rills, rill, gully and others. Also, at the end of the work, are presented suggestions for remediation of the site, considering corrective measures used within the context of conventional geotechnical practice, and a methodology to be followed in further investigations related to the characterization of the site and development of erosion processes.

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    Authors: Enrique Colado Varela;

    [ES] A pesar de los avances en el conocimiento de la patogenia de las leucemias agudas mieloblásticas, su tratamiento especifico no ha sido modificado substancialmente en las últimas décadas y una parte importante de los enfermos presentan resistencia terapéutica primario o falleciendo de su enfermedad. Basándose en esta hipótesis, esta tesis establece la eficacia antileucémica de fármacos clásicos como Arac- C, Fludarabina y Doxorubicina, con el fin de disponer de un patrón de referencia para la ulterior comparación con nuevos fármacos en fase preclínica/experimental. A continuación investiga la eficacia y mecanismo de acción de tres fármacos en fase preclínica: el inhibidor del proteasoma Bortezomib (PS-341), el inhibidor Pan-acetilasa: Panobinostat (LBH589) y la Zalypsis, un nuevo fármaco de origen marino. Y de cada fármaco se estudiará: el efecto antitumoral y el perfil de toxicidad, el posible sinergismo de las combinaciones de estos agentes con gentes clásicos, el efecto sobre el ciclo celular y apoptosis y los cambios que inducen en el perfil de expresión génica. [EN] Despite advances in understanding the pathogenesis of acute myeloblastic leukemia, no specific treatment has been modified substantially in recent decades and an important part of primary therapy patients show resistance or died of their disease. Based on this hypothesis, this thesis establishes the antileukemic efficacy of drugs such classics as Arac-C, fludarabine and doxorubicin, in order to provide a baseline for later comparison with new drugs in preclinical / experimental. It then investigates the efficacy and mechanism of action of three drugs in preclinical phase: the proteasome inhibitor Bortezomib (PS-341), the Pan-acetylase inhibitor: Panobinostat (LBH589) and Zalypsis, a new drug of marine origin. And for each drug will be studied: the antitumor activity and toxicity profile, the possible synergism of combinations of these agents with traditional people, the effect on the cell cycle and apoptosis and inducing changes in gene expression profiling.

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    Authors: Sierra A Ellison;

    Supplemented by the findings of her IRB certified research project, Sierra A. Ellison delves into the positive effects pop culture and genre have on the first-year composition classroom, exploring how engaging students through a common discourse that is relatable and comfortable can aid in their writing and composition progression. She explains how teaching under a framework such as the undead and examining these types of thematic material can engage students in the material and give students the space to open up about key issues like race, sex, politics, morality, and consumerism that they might be reluctant to discuss otherwise.

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    Исследование моделей трансляции знаний в так называемых практических науках в средиземноморском культурном круге XII – XIII вв.

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    Authors: Sofie van Rongen;

    The current physical food environment, characterized by a high availability energy-dense, palatable foods, is widely held responsible for unhealthy dietary patterns. However, our understanding of how the unhealthy food environment steers unhealthy food consumption, and how this may be of particular importance for individuals with low socioeconomic status, is still limited. The aim of this thesis is to provide insights into potential psychological processes that may explain how aspects of the physical food environment and socioeconomic context may steer unhealthy food consumption. Psychological theories on contextual influences on motivational and decision-making processes are applied specifically to the food environment and food consumption. Part 1 of this thesis (Chapters 2 and 3) focuses on social norms that may be communicated by physical food environments and thereby influence consumption. In part 2 (Chapters 4 and 5), the focus is on resource scarcity and relative deprivation, which may explain how an individual’s deprived socioeconomic context stimulates unhealthier food consumption when unhealthy foods are readily available.In Chapter 2, the aim is to provide a new understanding of how micro food environments may influence consumption, by proposing that social norms are embedded in physical cues in these environments. In this photo study, in-store/restaurant food environments were analysed through a social norm lens. It was demonstrated that a great variety of physical cues in self-service food environments (e.g. food traces, covered presentation, product availability) may communicate normative messages about other consumers’ behaviour or the popularity of/demand for a product (i.e. descriptive norms) and/or the appropriateness of consumption (i.e. injunctive norms). Among a sample of laypeople, a descriptive norm concerning others’ behaviour appeared easier to recognize than an injunctive norm regarding informal rules about appropriate behaviour. Findings suggest that social norms may be inferred from a wide variety of physical cues in the outside-the-home, in-store/restaurant food context.In Chapter 3, the proposition that the physical food environment conveys social norms regarding common and appropriate consumption is examined on the level of the built, neighbourhood environment. We tested whether social norm perceptions regarding fast food consumption in the neighbourhood mediated the relationship between residential exposure to fast food outlets and fast food consumption. Fast food outlet exposure was objectively assessed as the count of fast food outlets within a 400m walking distance buffer around the postcodes of Dutch panel respondents. No direct association between residential fast food exposure and frequency of fast food consumption was found. However, both descriptive and injunctive social norms mediated the association between exposure and consumption. Those who were more exposed to fast food outlets in their direct neighbourhood perceived ‘unhealthier’ social norms, and these ‘unhealthier’ norms were in turn associated with a higher frequency of fast food consumption. Hence, this chapter provides first correlational evidence for the idea that social norms may be inferred from the built physical food environment.In Chapter 4, the aim is to experimentally examine whether experiences of resource scarcity in an absolute sense (i.e. having too few resources) result in a higher consumption of available snacks. Scarcity experiences, including trade-off making, have been proposed to lead to a decreased mental bandwidth and so more impulsive behaviour. In our studies, resource scarcity was manipulated by a self-developed trade-off task, in which participants’ resources were either restricted (scarcity condition) or unrestricted (no-scarcity condition). Two laboratory experiments were conducted among students of Wageningen University. In the first experiment, a non-hypothesized interaction effect between scarcity and hunger bordered on significance. Scarcity appeared to increase snack consumption under low, but not high, hunger levels. In the second experiment, a difference in snack consumption between the two conditions could not be replicated, although participants were explicitly instructed to have eaten prior to participation so as to reduce their level of hunger. Overall, we could not provide conclusive evidence for the notion that resource scarcity results in unhealthier food consumption. In Chapter 5, the aim is to test whether the experience of personal relative deprivation (PRD, i.e. being worse off than others) results in a higher preference for palatable, high-caloric snack-type foods. PRD has been demonstrated to increase the preference for immediate, small rewards over larger benefits in the long term. In our studies, PRD was manipulated by a computer game in which participants experienced that they earned fewer resources (PRD condition) versus equal resources (control condition) relative to an opponent. The points earned served as resources to be spent on foods in a grocery shopping task. In an online experiment, no main effect of PRD on food choice was found. However, the manipulation appeared to have a differential effect for different levels of chronic PRD. A higher number of snack-type food products was selected by participants that were relatively deprived and also experienced higher chronic relative deprivation. In a lab-in-the-field experiment, where a diverse community sample made real (non-hypothetical) food choices, it was demonstrated that those in the PRD condition selected more snack-type foods compared to those in the control condition, when particularly sensitivity to palatable food was controlled for. Although results need to be interpreted with caution, this study revealed some preliminary evidence that relative deprivation results in unhealthier food choices. Overall, findings from part 1 indicate that the real-world physical food environment may be a relevant source of social norm perceptions about what is common and appropriate food consumption. Moreover, these findings highlight the importance of human social cognition when a person is interpreting physical contexts, as they show that perceptions of social norms may be a psychological mechanism in the relation between the physical food environment and consumption. The findings in part 2 are somewhat inconclusive, but they indicate that deprivation in a relative sense through upward social comparison may result in unhealthier food choice, but that deprivation in an absolute sense does not consistently result in unhealthier food consumption. In a practical sense, this thesis suggests that social norms and PRD may be relevant psychological processes that need to be considered when the aim is to stimulate healthier consumption and reduce socioeconomic disparities in diet.

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    Other literature type . Doctoral thesis . 2021
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    Doctoral thesis . Thesis . 2021
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