Huntington’s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we pre...

// Li Qin 1 , Yan Xu 2, 3 , Yixiang Xu 1, 4 , Gang Ma 1 , Lan Liao 1 , Yelin Wu 1, 5 , Yi Li 6 , Xian Wang 6 , Xiaosong Wang 6 , Jun Jiang 3 , Jin Wang 7 , Jianming Xu 1, 8 1 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA 2 De...

Abstract Over 100 million Americans experience recurrent aphthous stomatitis (RAS) at some point in life. To develop targeted drugs for RAS treatment, it is critical to identify its etiology. We determined if serum insulin‐like growth factor 1 (IGF‐1) and related factor...

Background Despite progress in cocaine immunotherapy, the kinetic and thermodynamic properties of antibodies which bind to cocaine and its metabolites are not well understood. It is also not clear how the interactions between them differ in a complex matrix such as the ...

Background: Identifying and characterizing how mixtures of exposures are associated with health endpoints is challenging. We demonstrate how classification and regression trees can be used to generate hypotheses regarding joint effects from exposure mixtures. Methods: W...

Background Electronic harassment affects 20–40% of adolescents and has been associated with significant negative outcomes including physical (ex. headache, abdominal pain), psychological (ex. depression, anxiety), and psychosocial (ex. school avoidance) problems. Eviden...

<jats:title>Summary</jats:title><jats:p>Recent evidence demonstrates that novel protein-coding genes can arise<jats:italic>de novo</jats:italic>from intergenic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of intergenic tra...

Regulation of membrane receptor mobility tunes cellular response to external signals, such as in binding of B cell receptors (BCR) to antigen, which initiates signaling. However, whether BCR signaling is regulated by BCR mobility, and what factors mediate this regulatio...

Little is known about the effect of migraine on neural cognitive networks. However, cognitive dysfunction is increasingly being recognized as a comorbidity of chronic pain. Pain appears to affect cognitive ability and the function of cognitive networks over time, and de...

Complex tumor-host interactions can significantly affect the growth dynamics and morphologies of progressing neoplasms. The growth of a confined solid tumor induces mechanical pressure and deformation of the surrounding microenvironment, which in turn influences tumor g...