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75,514 research outcomes, page 1 of 7,552
  • publication . Article . 2015
    Open Access
    Authors:
    Theodoros P. Zanos; Patrick J. Mineault; Konstantinos Nasiotis; Daniel Guitton; Christopher C. Pack;
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: CIHR

    SummaryTraveling waves of neural activity are frequently observed to occur in concert with the presentation of a sensory stimulus or the execution of a movement. Although such waves have been studied for decades, little is known about their function. Here we show that t...

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  • publication . Article . 2019
    Open Access
    Authors:
    Mohamed, Nguyen-Vi; Mathur, Meghna; da Silva, Ronan V.; Beitel, Lenore K.; Fon, Edward A.; Durcan, Thomas M.;
    Persistent Identifiers
    Publisher: F1000 ( Faculty of 1000 Ltd)
    Project: CIHR

    The development of brain organoids represents a major technological advance in the stem cell field, a novel bridge between traditional 2D cultures and in vivo animal models. In particular, the development of midbrain organoids containing functional dopaminergic neurons ...

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  • publication . Article . 2017
    Open Access
    Authors:
    Page, Melissa M.; Skovsø, Søs; Cen, Haoning; Chiu, Amy P.; Dionne, Derek A.; Hutchinson, Daria F.; Lim, Gareth E.; Szabat, Marta; Flibotte, Stephane; Sinha, Sunita; ...
    Persistent Identifiers
    Publisher: Wiley
    Project: CIHR

    Excess circulating insulin is associated with obesity in humans and in animal models. However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been questioned because of the absence of clear evidence that weight loss can be induced by acute...

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  • publication . Article . 2016
    Open Access
    Authors:
    Poon, Art F. Y.; Gustafson, Réka; Daly, Patricia; Zerr, Laura; Demlow, S. Ellen; Wong, Jason; Woods, Conan K; Hogg, Robert S.; Krajden, Mel; Moore, David; ...
    Publisher: Elsevier BV
    Project: NIH | Seek and Treat for Optima... (5R01DA036307-04), NIH | Evaluating the natural hi... (3R01DA011591-12S1), CIHR , NIH | HAART optimism, drug use ... (5R01DA031055-05), NIH | Impacts of universal acce... (1R01DA021525-01A2)

    Background Due to the rapid evolution of HIV, infections with similar genetic sequences are likely to be related by recent transmission events. Clusters of related infections can represent subpopulations with high rates of HIV transmission. Here we describe the implemen...

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