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- publication . Other literature type . Article . 2019Open AccessAuthors:Anne Clarke; Thuva Vanniyasingam; Prathiba Harsha; James Paul; Jake Walsh; Lehana Thabane; Antonella Tidy; Matthew A. Chong; Diane Buckley; Michael McGillion; ...doi: 10.2196/14603pmc: PMC6913744pmid: 31661079Publisher: JMIR Publications Inc.Project: CIHR
<jats:sec> <jats:title>Background</jats:title> <jats:p>Research has shown that introducing electronic Health (eHealth) patient monitoring interventions can improve healthcare efficiency and clinical outcomes. The VIGILANCE (VItal siGns monItoring with continuous puLse o...
- publication . Other literature type . Article . 2011Open Access EnglishAuthors:Dongxia Yuan; Yue Chang; Yifan Liu; Jyoti Garg; Chengjie Fu; Jeffrey Fillingham; Jie Xiong; Ronald E. Pearlman; Wei Miao; Xingyi Lu;pmc: PMC3102692pmid: 21637855Project: NIH | Polycomb-mediated heteroc... (1R01GM087343-01A2), CIHR
Background: Genome-wide expression data of gene microarrays can be used to infer gene networks. At a cellular level, a gene network provides a picture of the modules in which genes are densely connected, and of the hub genes, which are highly connected with other genes....
- publication . Article . 2017Open AccessAuthors:Tim Storr; Simon Faissner; Simon Faissner; Kyle J. Korshavn; Michael R. Jones; Michael R. Jones; Christine Dyrager; V. Wee Yong; Zavier Vaillancourt; Peter K. Stys; ...doi: 10.1039/c7sc01269aPublisher: Royal Society of Chemistry (RSC)Project: CIHR
Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) plaque deposits. Increased oxidative stress, metal ion dysregulation, and the formation of toxic Aβ pept...
- publication . Article . 2019Open Access EnglishAuthors:Marrie, Ruth Ann; O’Mahony, Julia; Maxwell, Colleen J.; Ling, Vicki; Yeh, E. Ann; Arnold, Douglas L.; Bar-Or, Amit; Banwell, Brenda;pmc: PMC6559708pmid: 31185042Publisher: Public Library of ScienceProject: CIHR
We aimed to compare health care utilization of children with pediatric-onset multiple sclerosis to that of age, sex and geographically-matched children without multiple sclerosis. Using population-based administrative data from Ontario, Canada for the period 2003–2014, ...
- publication . Article . 2010Open AccessAuthors:Claudine G. James; T. Michael Underhill; Veronica Ulici; Frank Beier; Lee-Anne Stanton; Hanga Agoston;pmc: PMC2805713pmid: 20084171Publisher: Public Library of Science (PLoS)Project: CIHR
Background Endochondral ossification is a complex process involving a series of events that are initiated by the establishment of a chondrogenic template and culminate in its replacement through the coordinated activity of osteoblasts, osteoclasts and endothelial cells....
- publication . Article . Other literature type . 2017Open AccessAuthors:Shaima Salman; Colin A. Nurse; Cathy Vollmer; Grant B. McClelland;pmc: PMC5625096pmid: 28637679Publisher: American Physiological SocietyProject: NSERC , CIHR
<jats:p> The carotid body (CB) chemoreflex maintains blood Po<jats:sub>2</jats:sub> and Pco<jats:sub>2</jats:sub>/H<jats:sup>+</jats:sup> homeostasis and displays sensory plasticity during exposure to chronic hypoxia. Purinergic signaling via P1 and P2 receptors plays a...
- publication . Other literature type . Article . 2018Open AccessAuthors:Trevor Hancock; Thea van Roode; Bruce Wallace; Albert Kwan; Samantha Tong; Bernadette Pauly; Kathleen Perkin; Tobie Patterson; Cheryl Prescott; Marjorie MacDonald; ...pmc: PMC5914026pmid: 29688855Publisher: Springer Science and Business Media LLCProject: CIHR
Abstract Background Promoting health equity within health systems is a priority and challenge worldwide. Health equity tools have been identified as one strategy for integrating health equity considerations into health systems. Although there has been a proliferation of...
- publication . Article . Other literature type . 2018Open AccessAuthors:Erica Thomson; Erica Thomson; Jane A. Buxton; Martin Bouchard; Delilah Gregg; Ehsan Jozaghi; Samona Marsh;Publisher: SAGE PublicationsProject: CIHR
<jats:sec><jats:title>Background:</jats:title><jats:p> Global cases of overdose-related deaths attributed to synthetic opioids are reaching epidemic proportion in many jurisdictions. While the main focus of health agencies and the different levels of government has been...
- publication . Article . Preprint . Other literature type . 2019Open AccessAuthors:Jeroen Baardman; Henrik Oerum; Menno P.J. de Winther; Rab K. Prinjha; Brante P. Sampey; Marc Feldmann; Susanna Obad; Paul Wordsworth; David Ahern; Palwinder K. Mander; ...pmc: PMC7084125 ...Publisher: Proceedings of the National Academy of SciencesProject: CIHR , WT , EC | FCFP (609305)
Significance T cells control many immune functions, with Th17 cells critical in regulating inflammation. Following activation, T cells undergo metabolic reprogramming and utilize glycolysis to increase the ATP availability. Epigenetic mechanisms controlling metabolic fu...
- publication . Article . 2018Open AccessAuthors:Bing Han; Xiao-Yan Wen; Alice Luo; Julie Khang; Yimin Li; Diana Islam; Nanshan Zhong; Kaijiang Yu; Haibo Zhang; Haibo Zhang; ...pmc: PMC6162902pmid: 30268129Publisher: Springer Science and Business Media LLCProject: CIHR
Abstract Background Pneumonia is a major cause of high morbidity and mortality in critically illness, and frequently requires support with mechanical ventilation. The latter can lead to ventilator-induced lung injury characterized by neutrophil infiltration. The cationi...