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- publication . Preprint . Article . 2020Open Access EnglishAuthors:Sorzano, carlos oscar; Crisman, Enrique; Carazo, Jose Maria; leon, rafael;Project: EC | HighResCells (810057), EC | CORBEL (654248), EC | EOSC-synergy (857647), EC | IMpaCT (857203), EC | iNEXT-Discovery (871037), EC | EOSC-Life (824087), EC | INSTRUCT-ULTRA (731005)
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- publication . Article . 2018Open Access EnglishAuthors:Baker, Lindsay A.; Sinnige, Tessa; Schellenberger, Pascale; De Keyzer, Jeanine; Siebert, C. Alistair; Driessen, Arnold J. M.; Baldus, Marc; Grünewald, Kay;Project: CIHR , EC | iNEXT (653706), WT | Membrane remodelling by v... (090895), NWO | Towards in-situ structura... (2300163571), NWO | Membrane proteins at work... (2300154435), WT | Understanding the genetic... (090532)
Membrane proteins remain challenging targets for structural biology, despite much effort, as their native environment is heterogeneous and complex. Most methods rely on detergents to extract membrane proteins from their native environment, but this removal can significa...
- publication . Doctoral thesis . 2015Open Access FrenchAuthors:Bazin, Alexandre;Publisher: HAL CCSD
During bacterial chromosomal replication, unwinding of double stranded DNA is performed by the hexameric helicase DnaB. In Escherichia coli, the positioning of DnaB hexamers onto replication forks in the 5’to 3’ direction is dedicated by helicase loader. DnaB then inter...
- publication . Article . 2014Open Access EnglishAuthors:Mariusz Olczak; Richard W. Strange; Justyna Ciuraszkiewicz; Teresa Olczak; Svetlana V. Antonyuk;pmc: PMC4062093pmid: 25075326Publisher: International Union of CrystallographyProject: EC | BIOSTRUCT-X (283570)
The plant purple acid phosphatase PPD1 forms a novel hexameric structure with a fibronectin III-like domain that is involved in DNA selectivity, binding and activation. The degradation of DNA by PPD1 implies a role for PPD1 in plant growth and repair and in pathogen def...
- publication . Article . 2020Open Access EnglishAuthors:Christophe Lotz; Valérie Lamour;Publisher: HAL CCSDProject: ANR | INRT (10-LABX-0030)
International audience; The type 2 DNA topoisomerases (Top2) are conserved enzymes and biomarkers for cell proliferation. The catalytic activities of the human isoform Top2α are essential for the regulation of DNA topology during DNA replication, transcription, and chro...
- publication . Article . Preprint . Other literature type . 2019Open AccessAuthors:Haydyn D. T. Mertens; Dmitry S. Molodenskiy; Dmitri I. Svergun;pmc: PMC7228933 ...Publisher: Springer Science and Business Media LLCProject: EC | iNEXT (653706)
<jats:title>Abstract</jats:title><jats:p>The application of small angle X-ray scattering (SAXS) to the structural characterization of transmembrane proteins (MPs) in detergent solutions has become a routine procedure at the most synchrotron BioSAXS beamlines around the ...
- publication . Other literature type . Article . 2019Open AccessAuthors:Ramon Hurtado-Guerrero; Francisco Corzana; Katrine T. Schjoldager; Henrik Clausen; Filipa Marcelo; Jesús Jiménez-Barbero; Jesús Jiménez-Barbero; Matilde de las Rivas; Ismael Compañón; Ana Diniz; ...Publisher: WileyProject: EC | LTFCOFUND2013 (609409), EC | BIOSTRUCT-X (283570)
The family of polypeptide N-acetylgalactosamine (GalNAc) transferases (GalNAc-Ts) orchestrates the initiating step of mucin-type protein O-glycosylation by transfer of GalNAc moieties to serine and threonine residues in proteins. Deficiencies and dysregulation of GalNAc...
- publication . Article . Other literature type . 2016Open AccessAuthors:Klaartje Houben; Mohammed Kaplan; Sander van Doorn; Lukas C. Kapitein; Dušan Popov-Čeleketić; Marc Baldus; Eugene A. Katrukha; Purvi Jain; Deni Mance; Gert E. Folkers; ...pmid: 27839865Publisher: Elsevier BVProject: EC | iNEXT (653706)
The epidermal growth factor receptor (EGFR) represents one of the most common target proteins in anti-cancer therapy. To directly examine the structural and dynamical properties of EGFR activation by the epidermal growth factor (EGF) in native membranes, we have develop...
- publication . Article . 2017Open AccessAuthors:András Ács; Beáta Biri-Kovács; Lilla Turiák; Andrea Bodor; Bálint Szeder; Attila Reményi; Ádám Póti; László Nyitray; Gergő Gógl; Gergő Gógl; ...doi: 10.1111/febs.14311Publisher: WileyProject: EC | iNEXT (653706)
Assembly and disassembly of protein-protein complexes needs to be dynamically controlled and phosphoswitches based upon linear motifs are crucial in this process. Extracellular signal regulated kinase 2 (ERK2) recognizes a linear binding motif at the C-terminal tail (CT...
- publication . Preprint . 2017Open Access EnglishAuthors:Georgia M Cook; Chris H. Hill; Stephen C. Graham; Samantha J. Spratley; Janet E. Deane;doi: 10.1101/112029Publisher: Cold Spring Harbor LaboratoryProject: EC | BIOSTRUCT-X (283570), WT | Molecular mechanisms of m... (098406), RCUK | Glycosphingolipid recycli... (MR/N020626/1)
<jats:title>Abstract</jats:title><jats:p>Sphingolipids are essential components of cellular membranes and defects in their synthesis or degradation cause severe human diseases. The efficient degradation of sphingolipids in the lysosome requires lipid-binding saposin pro...