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1,848 research outcomes, page 1 of 185
  • publication . 2018
    Multimerization of HIV-1 integrase hinges on conserved SH3-docking platforms
    Open Access
    Authors:
    Galilee, Meytal; Alian, Akram;
    Persistent Identifiers

    doi: 10.1101/301721

    Publisher: bioRxiv
    Project: EC | iNEXT (653706)

    ABSTRACTNew anti-AIDS treatments must be continually developed in order to overcome resistance mutations including those emerging in the newest therapeutic target, the viral integrase (IN). Multimerization of IN is functionally imperative and provides a forthcoming ther...

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  • publication . Article . 2020
    Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade
    Open Access English
    Authors:
    Guillaume Tetreau; Anne-Sophie Banneville; Elena A. Andreeva; Aaron S. Brewster; Mark S. Hunter; Raymond G. Sierra; Jean-Marie Teulon; Iris D. Young; Niamh Burke; Tilman A. Grünewald; ...
    Persistent Identifiers

    doi: 10.1038/s41467-020-14894-w

    pmc: PMC7052140

    pmid: 32123169

    Publisher: HAL CCSD
    Countries: France, United States
    Project: NIH | A Synchroton Radiation St... (8P41GM103393-33), ANR | CBH-EUR-GS (ANR-17-EURE-0003), NIH | Pacific Southwest Regiona... (1U01CK000516-01), NIH | Highly Improved Bacterial... (1U01AI054778-01), NIH | DIALS: New Computational ... (5R01GM117126-02), ANR | X-in-vivo (ANR-17-CE11-0018), NIH | A SYNCHROTRON RADIATION B... (5P41RR001209-14), NIH | Molecular Improvement of ... (5R01AI045817-04), ANR | DynOCP (ANR-18-CE11-0005)

    Cyt1Aa is the one of four crystalline protoxins produced by mosquitocidal bacterium Bacillus thuringiensis israelensis (Bti) that has been shown to delay the evolution of insect resistance in the field. Limiting our understanding of Bti efficacy and the path to improved...

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  • publication . Article . 2019
    Parents of early‐maturing girls die younger
    Open Access
    Authors:
    Hõrak, Peeter; Valge, Markus; Fischer, Krista; Mägi, Reedik; Kaart, Tanel;
    Persistent Identifiers

    doi: 10.1111/eva.12780

    pmc: PMC6503892

    pmid: 31080514

    Publisher: Wiley
    Project: EC | ADOPT BBMRI-ERIC (676550), EC | WIDENLIFE (692065), EC | ePerMed (692145), EC | CORBEL (654248)

    Abstract According to the life‐history theory, rates of sexual maturation have coevolved with mortality rates so that individuals who mature faster tend to die younger. We used two data sets, providing different markers for the speed of pubertal development to test whet...

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  • publication . Article . 2015
    Structure–Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid
    Authors:
    Niels Krogsgaard-Larsen; Morten Storgaard; Charlotte Møller; Charles S. Demmer; J.B. Hansen; Liwei Han; Rune N. Monrad; Birgitte Nielsen; Daniel Tapken; Darryl S. Pickering; ...
    Persistent Identifiers

    doi: 10.1021/acs.jmedchem.5b00750

    Publisher: American Chemical Society (ACS)
    Project: EC | BIOSTRUCT-X (283570)

    Herein we describe the first structure–activity relationship study of the broad-range iGluR antagonist (2S,3R)-3-(3-carboxyphenyl)pyrrolidine-2-carboxylic acid (1) by exploring the pharmacological effect of substituents in the 4, 4′, or 5′ positions and the bioisosteric...

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  • publication . Article . Other literature type . 2020
    Structural and DNA binding properties of mycobacterial integration host factor mIHF
    Open Access English
    Authors:
    Odermatt, Nina,; Lelli, Moreno; Herrmann, Torsten; Abriata, Luciano,; Japaridze, Aleksandre; Voilquin, Hubert; Singh, Rajkumar; Piton, Jérémie; Emsley, Lyndon; Dietler, Giovanni; ...
    Persistent Identifiers

    doi: 10.1016/j.jsb.2019.107434

    Publisher: HAL CCSD
    Countries: Switzerland, France
    Project: EC | iNEXT (653706)

    Abstract In bacteria, nucleoid associated proteins (NAPs) take part in active chromosome organization by supercoil management, three-dimensional DNA looping and direct transcriptional control. Mycobacterial integration host factor (mIHF, rv1388) is a NAP restricted to A...

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  • publication . Article . Other literature type . 2018
    The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.
    Open Access
    Authors:
    Weinhäupl, Katharina; Brennich, Martha; Kazmaier, Uli; Lelièvre, Joël; Ballell, Lluis; Goldberg, Alfred; Schanda, Paul; Fraga, Hugo;
    Persistent Identifiers

    doi: 10.1074/jbc.ra118.002251

    pmc: PMC5986217

    pmid: 29632076

    Country: France

    Mycobacterium tuberculosis can remain dormant in the host, an ability that explains the failure of many current tuberculosis treatments. Recently, the natural products cyclomarin, ecumicin, and lassomycin have been shown to efficiently kill Mycobacterium tuberculosis pe...

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  • publication . Doctoral thesis . 2020
    Design, Synthesis and Optimization of Paramagnetic Tags for NMR Spectroscopy
    Open Access English
    Authors:
    Denis, Maxime Jacques Gil;
    Country: Italy
    Project: EC | AEGIS (675555), EC | iNEXT (653706)
  • publication . Article . 2016
    Development and structural analysis of adenosine site binding tankyrase inhibitors
    Open Access
    Authors:
    Haikarainen, Teemu; Waaler, Jo; Ignatev, Alexander; Nkizinkiko, Yves; Venkannagari, Harikanth; Obaji, Ezeogo; Krauss, Stefan; Lehtiö, Lari;
    Persistent Identifiers

    doi: 10.1016/j.bmcl.2015.12.018

    Publisher: Elsevier BV
    Project: EC | BIOSTRUCT-X (283570), AKA | Characterization of poly(... (266922)

    AbstractTankyrases 1 and 2, the specialized members of the ARTD protein family, are druggable biotargets whose inhibition may have therapeutic potential against cancer, metabolic disease, fibrotic disease, fibrotic wound healing and HSV viral infections. We have previou...

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  • publication . Article . 2019
    Real-Time Insights into Biological Events: In-Cell Processes and Protein-Ligand Interactions
    Open Access
    Authors:
    Linda Cerofolini; Stefano Giuntini; Letizia Barbieri; Matteo Pennestri; Anna Codina; Marco Fragai; Lucia Banci; Enrico Luchinat; Enrico Ravera;
    Persistent Identifiers

    doi: 10.1016/j.bpj.2018.11.3132

    pmc: PMC6350048

    pmid: 30580921

    Country: Italy
    Project: EC | West-Life (675858), EC | INSTRUCT-ULTRA (731005), EC | iNEXT (653706)

    FlowNMR has the aim of continuously monitoring processes that occur in conditions that are not compatible with being carried out within a closed tube. However, it is sample intensive and not suitable for samples, such as proteins or living cells, that are often availabl...

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  • publication . Article . 2017
    ATSAS 2.8 : a comprehensive data analysis suite for small-angle scattering from macromolecular solutions
    Open Access
    Authors:
    Franke, D.; Petoukhov, M. V.; Konarev, P. V.; Panjkovich, A.; Tuukkanen, A.; Mertens, H. D. T.; Kikhney, A. G.; Hajizadeh, N. R.; Franklin, J. M.; Jeffries, C. M.; ...
    Persistent Identifiers

    doi: 10.1107/s1600576717007786

    pmc: PMC5541357

    pmid: 28808438

    Publisher: International Union of Crystallography (IUCr)
    Project: EC | iNEXT (653706), EC | IDPBYNMR (264257), EC | BIOSTRUCT-X (283570)

    ATSAS is a comprehensive software suite for the analysis of small-angle scattering data from dilute solutions of biological macromolecules or nanoparticles. It contains applications for primary data processing and assessment, ab initio bead modelling, and model validati...

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1,848 research outcomes, page 1 of 185