Filters (2 )
Download Results
143,046 research outcomes, page 1 of 14,305
  • publication . Article . 1997
    Open Access
    Authors:
    C J Dawe; Thomas L. Benjamin; John B. Carroll; Roderick T. Bronson;
    Publisher: Proceedings of the National Academy of Sciences

    Transformation of cells in culture by polyoma virus requires integration of signals downstream of middle T–Shc and middle T-phosphatidylinositol 3-kinase interactions, but the same is not true for induction of tumors in the mouse. Thus, a middle T mutant defective in tr...

    Add to ORCID
  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Jenny Chong; Wei Wang; Mikhail Kashlev; Celine Walmacq; Dong Wang;
    Publisher: Proceedings of the National Academy of Sciences

    <jats:p>Abasic sites are among the most abundant DNA lesions and interfere with DNA replication and transcription, but the mechanism of their action on transcription remains unknown. Here we applied a combined structural and biochemical approach for a comprehensive inve...

    Add to ORCID
  • publication . Other literature type . Article . 1988
    Open Access
    Authors:
    Paul Talalay; H. J. Prochaska; M J De Long;
    Publisher: Proceedings of the National Academy of Sciences

    Carcinogenesis is blocked by an extraordinary variety of agents belonging to many different classes--e.g., phenolic antioxidants, azo dyes, polycyclic aromatics, flavonoids, coumarins, cinnamates, indoles, isothiocyanates, 1,2-dithiol-3-thiones, and thiocarbamates. The ...

    Add to ORCID
  • publication . Other literature type . Article . 2018
    Open Access English
    Authors:
    Michele De Luca; Vadim Lincoln; David T. Woodley; Yingping Hou; Michelle Hao; Mei Chen; Michaela Hirsch; Johann W. Bauer; Laura De Rosa; Jon Cogan; ...
    Publisher: National Academy of Sciences

    <jats:p>Herlitz junctional epidermolysis bullosa (H-JEB) is an incurable, devastating, and mostly fatal inherited skin disease for which there is only supportive care. H-JEB is caused by loss-of-function mutations in <jats:italic>LAMA3</jats:italic>, <jats:italic>LAMB3<...

    Add to ORCID
  • publication . Other literature type . Article . 1972
    Open Access English
    Authors:
    Edgar Haber; Kevin J. Fraser; Knud Poulsen;

    Abstract The immunoglobulin light chain is thought to be organized into two structural domains, the constant and the variable regions, linked by a switch region of lesser tertiary organization. Light chains of homogeneous rabbit antibodies to pneumococcal polysaccharide...

    Add to ORCID
  • publication . Article . Other literature type . 2012
    Open Access
    Authors:
    Dale B. Wigley; Liang Yang; Stephen C. Kowalczykowski; Naofumi Handa; Naofumi Handa; Mark S. Dillingham; Bian Liu;

    The RecBCD enzyme is a complex heterotrimeric helicase/nuclease that initiates recombination at double-stranded DNA breaks. In Escherichia coli, its activities are regulated by the octameric recombination hotspot, χ (5′-GCTGGTGG), which is read as a single-stranded DNA ...

    Add to ORCID
  • publication . Article . Other literature type . 1975
    Open Access
    Authors:
    Eric Eisenstadt; Rita Lange; Klaus Willecke;
    Publisher: Proceedings of the National Academy of Sciences

    Abstract A protein activity has been detected in soluble extracts of competent cultures of bacillus subtilis which protects denatured DNA from nuclease solubilization. Both binding activity and competence development occur simultaneously but not coordinately, since the ...

    Add to ORCID
  • publication . Other literature type . Article . 2005
    Open Access English
    Authors:
    David Botstein; Hao Li; Yigal D. Nochomovitz; Emmitt R. Jolly; Wei Wang; J. Michael Cherry;
    Publisher: National Academy of Sciences

    Decomposing transcriptional regulatory networks into functional modules and determining logical relations between them is the first step toward understanding transcriptional regulation at the system level. Modules based on analysis of genome-scale data can serve as the ...

    Add to ORCID
  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    J.E. Colgate; Roberta L. Klatzky; Michael A. Peshkin; Steven G. Manuel;
    Publisher: Proceedings of the National Academy of Sciences
    Add to ORCID
  • publication . Article . 1997
    Open Access
    Authors:
    Eric M. Gordon; Mark A. Gallop; Martin M. Murphy; John R. Schullek; Derek Maclean; Zhi-Jie Ni;
    Publisher: Proceedings of the National Academy of Sciences

    The application of a new encoding technology for drug discovery is described. A combinatorial library of mercaptoacyl pyrrolidines has been prepared on a beaded polymeric support. Each polymer bead carries one library constituent in association with an oligomeric “tag,”...

    Add to ORCID
143,046 research outcomes, page 1 of 14,305