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105,436 research outcomes, page 1 of 10,544
  • publication . Other literature type . Article . 2011
    Open Access
    Authors:
    John O. Cisar; C. Allen Bush; Moon H. Nahm; Yang Jinghua;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)

    <jats:p><jats:italic>Streptococcus pneumoniae</jats:italic> serogroup 10 includes four cross-reactive capsular polysaccharide (CPS) serotypes (10F, 10A, 10B, and 10C). In the present study, the structures of CPS10B and CPS10C were determined by chemical and high resolut...

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  • publication . Article . 2005
    Open Access
    Authors:
    Shashi K. Ramaiah; Robert C. Burghardt; Kyungsil Yoon; Stephen Safe; Sabitha Papineni; Sudhakar Chintharlapalli;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)

    Nur77 is an orphan receptor and a member of the nerve growth factor-I-B subfamily of the nuclear receptor family of transcription factors. Based on the results of transactivation assays in pancreatic and other cancer cell lines, we have now identified for the first time...

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  • publication . Other literature type . Article . 2020
    Open Access English
    Authors:
    Jin Ye;
    Publisher: American Society for Biochemistry and Molecular Biology

    <jats:p>Transmembrane proteins are membrane-anchored proteins whose topologies are important for their functions. These properties enable regulation of certain transmembrane proteins by regulated intramembrane proteolysis (RIP) and regulated alternative translocation (R...

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  • publication . Article . 2010
    Open Access
    Authors:
    Steve P. Watson; Diego Mourão-Sá; Leyre Navarro-Núñez; Sonia Severin; Craig A. Nash; Alice Y. Pollitt; Yotis A. Senis; Johannes A. Eble;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: WT | The early events in signa... (088410)

    The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). In this study, we show that phosphorylation of CLEC-2 by the snake toxin rhodocytin is aboli...

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  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Fazlul Karim; Masahiro Inoue; Kazuya Yamagata; Tomonori Tsuyama; Yoshifumi Sato; Tatsuya Yoshizawa; Chinami Sato;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)

    Abstract Hypoxia plays a role in the deterioration of β-cell function. Hepatocyte nuclear factor 4α (HNF4α) has an important role in pancreatic β-cells, and mutations of the human HNF4A gene cause a type of maturity-onset diabetes of the young (MODY1). However, it remai...

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  • publication . Article . 2003
    Open Access
    Authors:
    Steven J. Ludtke; Dan J. Bare; Wah Chiu; Gregory A. Mignery; Irina I. Serysheva; Claudia S. Kettlun;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)

    Abstract The three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor (InsP3R1) has been determined by electron cryomicroscopy and single-particle reconstruction. The receptor was immunoaffinity-purified and formed functional InsP3- and heparin-se...

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  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Wei Shao; Fang Huang; B. Matija Peterlin; Koh Fujinaga;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)

    Autoimmune regulator (AIRE) and nuclear factor-κB (NF-κB) are transcription factors (TFs) that direct the expression of individual genes and gene clusters. Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator that recognizes and binds to acetylated histone...

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  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Jeffrey Milbrandt; Yo Sasaki;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)

    Axonal degeneration is an early and important component of many neurological disorders. Overexpression of nicotinamide mononucleotide adenylyltransferase (Nmnat), a component of the slow Wallerian degeneration (Wlds) protein, protects axons from a variety of insults. We...

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  • publication . Article . 2009
    Open Access
    Authors:
    Jens Peter Andersen; Anne Nyholm Holdensen;
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)

    Abstract Ion translocation by the sarcoplasmic reticulum Ca2+-ATPase depends on large movements of the A-domain, but the driving forces have yet to be defined. The A-domain is connected to the ion-binding membranous part of the protein through linker regions. We have de...

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  • publication . Other literature type . Article . 2012
    Open Access English
    Authors:
    Paul R. Copeland; Kelvin Caban;
    Publisher: American Society for Biochemistry and Molecular Biology

    Abstract Sec-tRNASec is site-specifically delivered at defined UGA codons in selenoprotein mRNAs. This recoding event is specified by the selenocysteine insertion sequence (SECIS) element and requires the selenocysteine (Sec)-specific elongation factor, eEFSec, and the ...

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105,436 research outcomes, page 1 of 10,544