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85,047 research outcomes, page 1 of 8,505
  • publication . Article . Other literature type . 2008
    Open Access
    Authors:
    John Garthwaite;
    Publisher: Wiley
    Project: WT

    As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the nervous system, predating many of the more familiar neurotransmitters. During t...

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  • publication . Article . 2016
    Open Access
    Authors:
    Colin MacLeod; Jennifer L. Smith; Yohannes Letamo; Rebecca Willis; Emebet Mekonnen; Misganu Endriyas; Brian K. Chu; Michael Dejene; Wondu Alemayehu; Khumbo Kalua; ...
    Publisher: Informa UK Limited
    Project: WT , WT | Tools for the elimination... (098521)

    ABSTRACT Purpose: We sought to estimate the prevalence of trachoma at sufficiently fine resolution to allow elimination interventions to begin, where required, in the Southern Nations, Nationalities, and Peoples’ Region (SNNPR) of Ethiopia. Methods: We carried out cross...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Ioanna Tzani; Irwin Jungreis; Ivaylo Ivanov; Michael Power; John F. Atkins; John F. Atkins; Manolis Kellis; Gary Loughran; Ruslan I. Dmitriev;
    Persistent Identifiers
    Publisher: American Society for Biochemistry and Molecular Biology
    Project: NIH | GENCODE: comprehensive ge... (1U41HG007234-01), NIH | Regulatory Morif Discover... (1R01HG004037-01A1), SFI | Using ribosome profiling ... (12/IP/1492), SFI | Development of Bionic Sen... (13/SIRG/2144), NIH | GENCODE: comprehensive ge... (5U41HG007234-04), WT

    Although stop codon readthrough is used extensively by viruses to expand their gene expression, verified instances of mammalian readthrough have only recently been uncovered by systems biology and comparative genomics approaches. Previously, our analysis of conserved pr...

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  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Patricia A.J. Muller; Giuditta Viticchiè;
    Persistent Identifiers
    Publisher: MDPI AG
    Project: WT

    The c-Met receptor, also known as the HGF receptor, is one of the most studied tyrosine kinase receptors, yet its biological functions and activation mechanisms are still not fully understood. c-Met has been implicated in embryonic development and organogenesis, in tiss...

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  • publication . Article . 2010
    Open Access
    Authors:
    Anika Oellrich; Dietrich Rebholz-Schuhmann; Robert Hoehndorf;
    Publisher: Oxford University Press (OUP)
    Project: WT

    Motivation: Phenotypic information is important for the analysis of the molecular mechanisms underlying disease. A formal ontological representation of phenotypic information can help to identify, interpret and infer phenotypic traits based on experimental findings. The...

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  • publication . Article . 2012
    Open Access
    Authors:
    Olga Ksionda; Christoph Wülfing; Alexander Saveliev; Mustapha Faroudi; Jonathan Rapley; Tom Carter; Victor L. J. Tybulewicz; Robert Köchl; Jennifer E. Smith-Garvin; Katrin Rittinger;
    Persistent Identifiers
    Publisher: The Company of Biologists
    Project: WT | An RNAi screen for integr... (089185)

    Summary The antigen-specific binding of T cells to antigen presenting cells results in recruitment of signalling proteins to microclusters at the cell-cell interface known as the immunological synapse (IS). The Vav1 guanine nucleotide exchange factor plays a critical ro...

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  • publication . Review . Article . Other literature type . 2009
    Open Access English
    Authors:
    Gustavo Deco; Alexander Thiele;
    Publisher: WILEY-BLACKWELL PUBLISHING, INC
    Project: RCUK | Neuronal mechanisms and n... (G0700976), WT | Neuropharmacology of visu... (070380)

    Attention is a rich psychological and neurobiological construct that influences almost all aspects of cognitive behaviour. It enables enhanced processing of behaviourally relevant stimuli at the expense of irrelevant stimuli. At the cellular level, rhythmic synchronizat...

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  • publication . Article . 1999
    Open Access English
    Authors:
    Kaylene J. Raynes; Mathirut Mungthin; Stephen A. Ward; Omar Janneh; Patrick G. Bray; Hagai Ginsburg;
    Persistent Identifiers
    Publisher: The Rockefeller University Press
    Project: WT

    <jats:p>Here we provide definitive evidence that chloroquine (CQ) uptake in Plasmodium falciparum is determined by binding to ferriprotoporphyrin IX (FPIX). Specific proteinase inhibitors that block the degradation of hemoglobin and stop the generation of FPIX also inhi...

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  • publication . Preprint . 2017
    Open Access English
    Authors:
    Stephen D. Bentley; Joaquin M Prada; Khalil Abudahab; Nicholas J. Croucher; Jukka Corander; Zhirong Yang; David M. Aanensen;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: EC | SCARABEE (742158), WT | Evolutionary dynamics und... (104169)

    <jats:title>ABSTRACT</jats:title><jats:p>The standard workhorse for genomic analysis of the evolution of bacterial populations is phylogenetic modelling of mutations in the core genome. However, in the current era of population genomics, a notable amount of information ...

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  • publication . Preprint . Other literature type . 2018
    Open Access
    Authors:
    Alison G. Costigan; Andrew David Lawrence; Jiaxiang Zhang; Kim S. Graham; Esin Karahan;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Multi-scale and multi-mod... (104943), EC | FREEMIND (716321)

    <jats:title>Abstract</jats:title><jats:p>The speed of voluntary reaction to an external stimulus varies substantially between individuals and is impaired in ageing. However, the neuroanatomical origins of inter-individual variability in reaction time (RT) remain largely...

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85,047 research outcomes, page 1 of 8,505