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348,016 research outcomes, page 1 of 34,802
  • publication . Article . Conference object . 2019
    Open Access
    Authors:
    Bino Varghese; Frank Chen; Darryl Hwang; Suzanne L. Palmer; Andre Luis de Castro Abreu; Osamu Ukimura; Monish Aron; Manju Aron; Inderbir S. Gill; Vinay Duddalwar; ...
    Publisher: ACM
    Project: NIH | Big Data U: Empowering Mo... (5U24ES026465-03), NIH | Boosting the Translationa... (5R01GM114434-02)

    Abstract Multiparametric magnetic resonance imaging (mpMRI) has become increasingly important for the clinical assessment of prostate cancer (PCa), but its interpretation is generally variable due to its relatively subjective nature. Radiomics and classification methods...

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  • publication . Article . 2010
    Open Access
    Authors:
    Barbieri, Christopher M.; Mack, Timothy R.; Robinson, Victoria L.; Miller, Matthew T.; Stock, Ann M.;
    Persistent Identifiers
    Publisher: American Society for Biochemistry & Molecular Biology (ASBMB)
    Project: NIH | Structure and Function of... (5R37GM047958-11)

    DNA-binding response regulators (RRs) of the OmpR/PhoB subfamily alternate between inactive and active conformational states, with the latter having enhanced DNA-binding affinity. Phosphorylation of an aspartate residue in the receiver domain, usually via phosphotransfe...

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  • publication . Article . 1998
    Open Access English
    Authors:
    Matthew Bogyo; Sunny Shin; John S. McMaster; Hidde L. Ploegh;
    Persistent Identifiers
    Publisher: Published by Elsevier Ltd.
    Project: NIH | CELL BIOLOGY--DEVELOPMENT... (5P30CA014051-17)

    Abstract Background: The proteasome is a multicatalytic protease complex responsible for most cytosolic protein breakdown. The complex has several distinct proteolytic activities that are defined by the preference of each for the carboxyterminal (P1) amino acid residue....

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  • publication . Other literature type . 2018
    Authors:
    Rulan Griesel; Stewart, Annemie; Plas, Helen Van Der; Welile Sikhondze; Mendelson, Marc; Maartens, Gary;
    Publisher: figshare
    Project: NIH | An evidence based algorit... (1R01AI096735-01)

    Additional file 1. Additional figures and tables.

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  • publication . Article . 2012
    Open Access English
    Authors:
    Buganim, Yosef; Faddah, Dina A.; Cheng, Albert W.; Itskovich, Elena; Markoulaki, Styliani; Ganz, Kibibi; Klemm, Sandy L.; van Oudenaarden, Alexander; Jaenisch, Rudolf;
    Publisher: Elsevier Inc.
    Country: Netherlands
    Project: NIH | Stochastic gene expressio... (5DP1OD003936-02), NIH | In Vitro Reprogramming of... (5R37HD045022-13), NIH | Utilizing single cell app... (1F32GM099153-01A1), NIH | Organization and Infrastr... (5U54CA143874-04), NIH | GENOMIC IMPRINTING AND TH... (5R37CA084198-09)

    SummaryDuring cellular reprogramming, only a small fraction of cells become induced pluripotent stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based on populations of cells, impeding single-cell level identification of reprogramming e...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Clark, Lars E.; Mahmutovic, Selma; Raymond, Donald D.; Dilanyan, Taleen; Koma, Takaaki; Manning, John T.; Shankar, Sundaresh; Levis, Silvana C.; Briggiler, Ana M.; Enria, Delia A.; ...
    Persistent Identifiers
    Publisher: Springer Nature
    Country: United States
    Project: NIH | Antibody therapeutics for... (1DP5OD023084-01), NIH | INFECTIOUS DISEASE AND BA... (5T32AI007061-25)

    While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the vi...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Brian R. Herb; Molly S. Shook; Christopher J. Fields; Gene E. Robinson;
    Persistent Identifiers
    Publisher: BioMed Central
    Project: NIH | Dynamic and stable regula... (1R21MH107962-01)

    Background Aggression is influenced by individual variation in temperament as well as behavioral plasticity in response to adversity. DNA methylation is stably maintained over time, but also reversible in response to specific environmental conditions, and may thus be a ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Jens Cubick; Jörg M. Buchholz; Virginia Best; Mathieu Lavandier; Torsten Dau;
    Persistent Identifiers
    Countries: Denmark, France
    Project: NIH | Spatial hearing in speech... (5R01DC015760-03), ANR | CeLyA (ANR-10-LABX-0060)

    Cubick and Dau [(2016). Acta Acust. Acust. 102, 547-557] showed that speech reception thresholds (SRTs) in noise, obtained with normal-hearing listeners, were significantly higher with hearing aids (HAs) than without. Some listeners reported a change in their spatial pe...

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  • publication . Article . Other literature type . 2010
    Open Access
    Authors:
    Zheng, Hanqiao; Tang, Mingxin; Zheng, Qingwen; Kumarapeli, Asangi R. K.; Horak, Kathleen M.; Tian, Zongwen; Wang, Xuejun;
    Persistent Identifiers
    Publisher: Elsevier BV
    Project: NIH | Molecular Pathogenesis of... (5R01HL072166-09), NIH | The COP9 Signalosome in t... (2R01HL085629-10)

    ObjectivesThe goal of this pre-clinical study was to assess the therapeutic efficacy of doxycycline (Doxy) for desmin-related cardiomyopathy (DRC) and to elucidate the potential mechanisms involved.BackgroundDRC, exemplifying cardiac proteinopathy, is characterized by i...

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  • publication . Article . 2017
    Open Access
    Authors:
    Jeane Ann Grisso; Mary D. Sammel; Arthur H. Rubenstein; Rebecca M. Speck; Emily F. Conant; Patricia Scott; Lucy Wolf Tuton; Alyssa Friede Westring; Stewart D. Friedman; Stephanie Abbuhl;
    Persistent Identifiers
    Publisher: Mary Ann Liebert Inc
    Project: NIH | Achieving Success for Wom... (5R01NS069793-04)