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44,643 research outcomes, page 1 of 4,465
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Cristiane Naffah de Souza; Cristiane Naffah de Souza; Cristiane Naffah de Souza; Leandro C. D. Breda; Leandro C. D. Breda; Leandro C. D. Breda; Meraj A. Khan; Meraj A. Khan; Sandro Rogério de Almeida; Niels Olsen Saraiva Câmara; ...
    Publisher: Frontiers Media S.A.
    Project: CIHR , NSERC

    pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracell...

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  • publication . Article . 2005
    Open Access
    Authors:
    Weiping Shen; Steven Yun; Kush Dalal; Frederic Pio; Bonny Tam;
    Publisher: Springer Science and Business Media LLC
    Project: CIHR

    <p>Abstract</p> <p>Background</p> <p>Protein expression in <it>E. coli </it>is the most commonly used system to produce protein for structural studies, because it is fast and inexpensive and can produce large quantity of proteins. However, when proteins from other speci...

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  • publication . Other literature type . Article . 2011
    Open Access
    Authors:
    Pierre Dagenais; Pascale Legault; James G. Omichinski; Geneviève Di Tomasso; Philipe Lampron;
    Publisher: Oxford University Press (OUP)
    Project: CIHR

    Although RNA-based biological processes and therapeutics have gained increasing interest, purification of in vitro transcribed RNA generally relies on gel-based methods that are time-consuming, tedious and denature the RNA. Here, we present a reliable procedure for affi...

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  • publication . Article . 2011
    Open Access English
    Authors:
    Hutton, E. K.; Hannah, Mary E.; Ross, Sharon; Delisle, Marie-France; Carson, G. D.; Windrim, R.; Ohlsson, Arne; Willan, Andrew R.; Gafni, Amiram; Sylvestre, G.; ...
    Project: CIHR

    Please cite this paper as: Hutton E, Hannah M, Ross S, Delisle M, Carson G, Windrim R, Ohlsson A, Willan A, Gafni A, Sylvestre G, Natale R, Barrett Y, Pollard J, Dunn M, Turtle P, for the Early ECV2 Trial Collaborative Group. The Early External Cephalic Version (ECV) 2 ...

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  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Edmund Carvalho; Murray S. Junop; Muniswamy Madesh; Samuel K. Lee; Santhanam Shanmughapriya; Dhanendra Tomar; Mac C. Y. Mok; Zhiwei Dong; Peter B. Stathopulos; Sudarsan Rajan;
    Project: CIHR , NSERC

    Summary Calcium (Ca 2+ ) flux into the matrix is tightly controlled by the mitochondrial Ca 2+ uniporter (MCU) due to vital roles in cell death and bioenergetics. However, the precise atomic mechanisms of MCU regulation remain unclear. Here, we solved the crystal struct...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Simon E. Fisher; Simon E. Fisher; Fábio L.S. Duran; Stefan Ehrlich; Sara Calderoni; Celso Arango; Bob Oranje; Filippo Muratori; Sarah E. Medland; Declan G. Murphy; ...
    Project: EC | PSYSCAN (603196), EC | OPTIMISE (242114), EC | AIMS-2-TRIALS (777394), CIHR , EC | EU-GEI (241909), EC | METSY (602478), NWO | XCiDE: Crossing the Combu... (2300153186), NIH | ENIGMA Center for Worldwi... (3U54EB020403-04S1), EC | EU-AIMS (115300)

    Changes in brain structure asymmetry have been reported in autism spectrum disorder. Here the authors investigate this issue using a large-scale sample consisting of 54 data sets.

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    George Cairns; Armin Mäder; Clarke R. Slater; Emily O'Connor; Sally Spendiff; Rita Horvath; Andreas Roos; Stefan Hettwer; Hanns Lochmüller; Juliane S Müller; ...
    Publisher: Cells
    Project: CIHR

    <jats:p>Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterised by impaired function of the neuromuscular junction (NMJ). This is due to defects in one of the many proteins associated with the NMJ. In three patients with CMS, missens...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Jean Raymond; Andrew S. Jack; Tim E. Darsaut; Richard S. C. Kerr;
    Publisher: Springer Nature
    Project: CIHR

    Background The International Subarachnoid Aneurysm Trial (ISAT) demonstrated improved one-year clinical outcomes for patients with ruptured intracranial aneurysms treated with endovascular coiling compared to surgical clipping. Patients included in ISAT were mostly good...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Mackenzie Graham; Teneille E. Gofton; Charles Weijer; Loretta Norton; Bryan Young; Lorina Naci; Laura E. Gonzalez-Lara; Andrea Lazosky; Adrian M. Owen; Fiona Webster; ...
    Publisher: BioMed Central
    Project: CIHR

    Background: Patient outcome after serious brain injury is highly variable. Following a period of coma, some patients recover while others progress into a vegetative state (unresponsive wakefulness syndrome) or minimally conscious state. In both cases, assessment is diff...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Joel Gittelsohn; Anthony J.G. Hanley; Alaa Badawi; David E. C. Cole; Bernard Zinman; Mary Mamakeesick; Thomas M. S. Wolever; Sheena Kayaniyil; Jonathon L. Maguire; Sudaba Mansuri; ...
    Publisher: Taylor & Francis Group
    Project: CIHR

    Background . Sub-optimal vitamin D status is common worldwide and the condition may be associated with increased risk for various chronic diseases. In particular, low vitamin D status is highly prevalent in indigenous communities in Canada, although limited data are ava...

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44,643 research outcomes, page 1 of 4,465