We studied the coupled binding and folding of α-synuclein, an intrinsically disordered protein linked with Parkinson's disease. Using single-molecule fluorescence resonance energy transfer and correlation methods, we directly probed protein membrane association, structu...

The Cloud has become integral to most Internet-based applications and user gadgets. This article provides a brief history of the Cloud and presents a researcher's view of the prospects for innovating at the infrastructure, middleware, and application and delivery levels...

Ascribing mental states to non-human agents has been shown to increase their likeability and lead to better joint-task performance in human-robot interaction (HRI). However, it is currently unclear what physical features non-human agents need to possess in order to trig...

Abstract Alcohol use disorders (AUDs) cause serious problems in society and few effective treatments are available. Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study the neurobiological basis of human behavior with a conserved, fully tracta...

Memory CD8+ T cells are the pivotal component of adaptive immunity, however the signal and genetic pathways that govern their formation remain poorly defined. This study shows that the IL-10-IL-21-STAT3 pathway is critical for memory CD8+ T cell development following ac...

<jats:p><jats:italic>Streptococcus pneumoniae</jats:italic> serogroup 10 includes four cross-reactive capsular polysaccharide (CPS) serotypes (10F, 10A, 10B, and 10C). In the present study, the structures of CPS10B and CPS10C were determined by chemical and high resolut...

Successful corporate acquisitions require its managers to achieve substantial performance improvements in order to sufficiently cover acquisition premiums, the expected return of debt and equity investors, and the additional resources needed to capture synergies and acc...