BACKGROUND Combined BRAF-MEK inhibitor therapy is the standard of care for BRAF-mutant advanced melanoma. We investigated encorafenib, a BRAF inhibitor with unique target-binding properties, alone or in combination with the MEK inhibitor binimetinib, versus vemurafenib ...

In the title compound, C12H16N4O3, all bond lengths and angles are within normal ranges. An O—H⋯N and an N—H⋯O intra­molecular hydrogen bond contribute to the approximately planar mol­ecular conformation. In the crystal structure, inter­molecular N—H⋯O and N—H⋯N hydroge...

In many tokamaks ferromagnetic material, usually referred to as an iron-core, is present in order to improve the magnetic coupling between the solenoid and the plasma. The presence of the iron core in proximity to the plasma changes the magnetic topology with consequent...

Chronic lung disease: stay active to avoid depression and anxiety Patients with chronic lung disease who stay physically active could reduce their chances of depression and anxiety. Milo Puhan at the University of Zurich, Switzerland, and co-workers assessed the associa...

The road freight transportation-industry in the German speaking countries (Germany, Austria and Switzerland) faces high market pressure. Besides a high competition between the logistic service providers, shippers are exerting pressure too (Cordes, 2018). The market situ...

Pancreatic and duodenal homeobox 1 (PDX1) plays a crucial role in pancreas development, β-cell differentiation, and maintenance of mature β-cell function. In this study, we designed a strategy to produce PDX1-knockout (KO) pigs. A transcription activator-like effector n...

<jats:title>Abstract</jats:title><jats:p>Whole-genome sequencing (WGS) of microbial pathogens has become an essential part of modern epidemiological investigations. Although WGS data can be analyzed using a number of different approaches, such as traditional phylogeneti...

<jats:title>Abstract</jats:title> <jats:p>In this study, near-surface snow and graupel dynamics from formation to deposition are analyzed using WRF in a large-eddy configuration. The results reveal that a horizontal grid spacing of ≤50 m is required to resolve local oro...

The symptoms of patients with left personal neglect are characterized by inattention towards contralesional (left) body parts while at the same time explicitly ascertaining ownership for the neglected hemibody. It is currently unknown if personal neglect is associated w...