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  • Other research product . 2020
    Open Access English
    Authors: 
    Reis, Pedro;
    Publisher: SpringerOpen
    Country: Portugal
    Project: WT

    The exercise of Environmental Citizenship is strongly associated with a citizen’s capacity to act in society as an agent of change (ENEC 2018), and this depends on the development of a person’s willingness and competence for a critical, active and democratic engagement in preventing and solving environmental problems. There is a call for a citizenry that is well informed and empowered to take appropriate actions on the seriousness of the environmental problems affecting our world (Gray et al. 2009; Hodson 2003). However, many citizens do not feel empowered enough to participate in decision-making processes regarding socio-environmental issues, and, at the same time, the faith and trust in politicians have decreased, and political apathy is gaining ground (Hodson 2014). Throughout the past decade, the surge in authoritarian government practices, the failure of popular movements to replace undemocratic regimes and the increase in populist movements all over the world are fuelling concerns about a possible ‘democratic recession’ (Diamond 2015). Part of the success of this movement has been credited to the failures in mobilising young people’s political participation (Schulz et al. 2018; Jackson et al. 2016). Civic engagement depends on students and their ‘motivation to participate in civic activities, their confidence in the effectiveness of their participation, and their beliefs about their own capacity to become actively involved’ (Schulz et al. 2018, p. 72). Research shows that a student’s civic engagement can be supported and encouraged by school, with the help of (1) open school climates, (2) democratic structures within schools and (3) early opportunities for active participation, the promotion of students’ civic knowledge and the predisposition to engage in civic activities in the future (Schulz et al. 2018; Pancer 2015; Roth and Barton 2004). Therefore, education represents a key element in counteracting low levels of civic engagement among young people, namely, through the promotion of democratic activism (Hodson 2014).

  • Open Access English
    Authors: 
    Wathuo, Miriam; Medley, Graham; Nokes, D. James; Munywoki, Patrick K.;
    Publisher: F1000Research
    Country: United Kingdom
    Project: WT | Household transmission of... (090853), WT | Defining pathways of resp... (102975)

    Background: A better understanding of respiratory syncytial virus (RSV) epidemiology requires realistic estimates of RSV shedding patterns, quantities shed, and identification of the related underlying factors.\ud \ud Methods: RSV infection data arise from a cohort study of 47 households with 493 occupants, in coastal Kenya, during the 2009/2010 RSV season. Nasopharyngeal swabs were taken every 3 to 4 days and screened for RSV using a real time polymerase chain reaction (PCR) assay. The amount of virus shed was quantified by calculating the ‘area under the curve’ using the trapezoidal rule applied to rescaled PCR cycle threshold output. Multivariable linear regression was used to identify correlates of amount of virus shed.\ud \ud Results: The median quantity of virus shed per infection episode was 29.4 (95% CI: 15.2, 54.2) log10 ribonucleic acid (RNA) copies. Young age (<1 year), presence of upper respiratory symptoms, intra-household acquisition of infection, an individual’s first infection episode in the RSV season, and having a co-infection of RSV group A and B were associated with increased amount of virus shed.\ud \ud Conclusions: The findings provide insight into which groups of individuals have higher potential for transmission, information which may be useful in designing RSV prevention strategies.

  • Open Access English
    Authors: 
    Harrison, Jonathan;
    Publisher: Zenodo
    Project: UKRI | Kinetochore life-historie... (BB/R009503/1), WT | KINETOCHORES AS FORCE SEN... (106151), WT | Probing intra-cellular dy... (208384), UKRI | Kinetochore life-historie... (BB/R009503/1), WT | KINETOCHORES AS FORCE SEN... (106151), WT | Probing intra-cellular dy... (208384)

    Implementation of a minimal computational model of HURP dynamics on kinetochore-fibres and inference methods to fit this model to experimental data via Markov chain Monte Carlo.

  • Open Access English
    Authors: 
    Deans, Zandra C.; Costa, Jose Luis; Cree, Ian; Dequeker, Els; Edsjo, Anders; Henderson, Shirley; Hummel, Michael; Ligtenberg, Marjolijn J. L.; Loddo, Marco; Machado, Jose Carlos; +12 more
    Project: WT

    The clinical demand for mutation detection within multiple genes from a single tumour sample requires molecular diagnostic laboratories to develop rapid, high-throughput, highly sensitive, accurate and parallel testing within tight budget constraints. To meet this demand, many laboratories employ next-generation sequencing (NGS) based on small amplicons. Building on existing publications and general guidance for the clinical use of NGS and learnings from germline testing, the following guidelines establish consensus standards for somatic diagnostic testing, specifically for identifying and reporting mutations in solid tumours. These guidelines cover the testing strategy, implementation of testing within clinical service, sample requirements, data analysis and reporting of results. In conjunction with appropriate staff training and international standards for laboratory testing, these consensus standards for the use of NGS in molecular pathology of solid tumours will assist laboratories in implementing NGS in clinical services.

  • Open Access English
    Authors: 
    Bauer, Bruno; Stieg, Kerstin;
    Publisher: Transilvania University of Brasov
    Project: WT

    The following article provides an overview of Open Access Publishing in Austria in 2010. First of all, the participation of Austrian institutions in signing Open Access declarations and Open Access events in Austria are presented. Secondly, the article shows the development of both the Green Road to Open Access (repositories) as well as the Golden Road (Open Access Journals) in Austria. The article also describes the Open Access policies of the most important funding agency in Austria, the biggest university of the country as well as Universities Austria, the association of the 21 public universities in Austria. Finally, the paper raises the question of how Open Access is to be financed and explains the legal framework conditions for Open Access in Austria.

  • Other research product . Other ORP type . 2015
    Open Access English
    Authors: 
    Dijk, E.M.S.; Dimitropoulos, Harry; Iatropoulou, Katerina; Foufoulas, Ioannis;
    Publisher: OpenAIRE2020
    Project: WT , EC | OpenAIRE2020 (643410)

    This deliverable relates to the work carried out under task T8.3, “Research Impact Services”. The task’s focus is on the development of pilots with selected National funding agencies and infrastructure initiatives in order to serve them with the OpenAIRE research impact suite of services. A major service that OpenAIRE provides is the linking of research results to funding. Aside from importing the links from the repositories and journals, OpenAIRE designs, develops and enhances mining algorithms that identify and extract funding information from the text of scientific publications. With the help of NOADs we have initiated bi-lateral, often informal, collaborations with national funding agencies to facilitate mining extraction on their data. This is an on-going activity throughout the duration of the project. Currently the national funding agencies that we are working with are: FCT (Portugal), ARC (Australia), NHMRC (Australia), NSF & NIH (USA), SFI (Ireland), “Ministry of Science Education and Sport” & "Croatian Science Foundation” (Croatia), NWO (Netherlands), and DFG (Germany). This deliverable describes the nature of the data of the identified National funding agencies, as well as their export technologies, and provides the specification of the general-purpose OpenAIRE services required to support research impact measurements.

  • Open Access English
    Authors: 
    Reddy, Akhilesh B.;
    Publisher: Springer International Publishing
    Project: WT
  • Open Access English
    Authors: 
    Highton, David; Tachtsidis, Ilias; Tucker, Alison; Elwell, Clare; Smith, Martin;
    Publisher: Springer New York
    Project: WT
  • Other research product . Other ORP type . 2009
    Open Access English
    Authors: 
    Curtis, Lesley A.;
    Publisher: Personal Social Services Research Unit, University of Kent
    Country: United Kingdom
    Project: WT

    This is the seventeenth volume in a series of reports from a Department of Health-funded programme of work based at the Personal Social Services Research Unit at the University of Kent.

  • Open Access English
    Authors: 
    Zhiyi Wu; Philip Biggin;
    Publisher: Zenodo
    Project: WT | Oxford - OXION (203741), WT | Oxford - OXION (203741)

    This is a Gromacs port of the amber LIPID17 force field. To use this force field, the user can construct the lipid bilayer using Charmm-GUI and convert the atom names to the amber atom names using charmmlipid2amber.py. This port has also retained the modular feature of the LIPID17 force field, where the user can customise the head group or acryl chain and use pdb2gmx to construct the topology. The coordinate files for the amber lipids can also be obtained from the `gro` folder. The force field `lipid17.ff`, itp file `lipid17.itp` and a custom PI head group are all included in the attached compressed file. For the details of the generation and validation protocol, please consult the relevant Github page.

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