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description Publicationkeyboard_double_arrow_right Part of book or chapter of book 2001 EnglishOperational Research Society FCT | LA 1, FCT | LA 5FCT| LA 1 ,FCT| LA 5Alifantis, A.; Robinson, S.; Edwards, J.; Hurrion, R.; Ladbrook, J.; Waller, T.;CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2001Data sources: CORE (RIOXX-UK Aggregator)All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=core_ac_uk__::99657ce490972f661d5abae7f0569835&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
visibility 2visibility views 2 download downloads 60 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2001Data sources: CORE (RIOXX-UK Aggregator)All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=core_ac_uk__::99657ce490972f661d5abae7f0569835&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2016ACM Press Sergio Gutierrez-Santos; Stefano Capuzzi; Ken Kahn; Sokratis Karkalas; Alexandra Poulovassilis;We present and evaluate a web-based architecture for monitoring student-system interaction indicators in Exploratory Learning Environments (ELEs), using as our case study a microworld for secondary school algebra. We discuss the challenging role of teachers in exploratory learning settings and motivate the need for visualisation and notification tools that can assist teachers in focusing their attention across the class and inform teachers' interventions. We present an architecture that can support such Teacher Assistance tools and demonstrate its scalability to allow concurrent usage by thousands of users (students and teachers).
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . Conference object . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1145/2872518.2891075&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . Conference object . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1145/2872518.2891075&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 2022 FinlandSpringer International Publishing Authors: Jari Taskinen; Jani A. Virtanen;Jari Taskinen; Jani A. Virtanen;Peer reviewed
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2022Data sources: CORE (RIOXX-UK Aggregator)HELDA - Digital Repository of the University of HelsinkiPart of book or chapter of book . 2022Data sources: HELDA - Digital Repository of the University of Helsinkihttps://doi.org/10.1007/978-3-...Part of book or chapter of book . 2022License: https://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-031-02104-6_14&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!
visibility 6visibility views 6 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2022Data sources: CORE (RIOXX-UK Aggregator)HELDA - Digital Repository of the University of HelsinkiPart of book or chapter of book . 2022Data sources: HELDA - Digital Repository of the University of Helsinkihttps://doi.org/10.1007/978-3-...Part of book or chapter of book . 2022License: https://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-031-02104-6_14&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Conference object 2018 Netherlands, IrelandSpringer International Publishing Suominen, H.; Kelly, L.; Goeuriot, L.; Névéol, A.; Ramadier, L.; Robert, A.; Kanoulas, E.; Spijker, R.; Azzopardi, L.; Li, D.; Jimmy; Palotti, J.; Zuccon, G.; Bellot, P.; Trabelsi, C.; Mothe, J.; Murtagh, F.; Nie, J.Y.; Soulier, L.; SanJuan, E.; Cappellato, L.; Ferro, N.;In this paper, we provide an overview of the sixth annual edition of the CLEF eHealth evaluation lab. CLEF eHealth 2018 continues our evaluation resource building efforts around the easing and support of patients, their next-of-kins, clinical staff, and health scientists in understanding, accessing, and authoring eHealth information in a multilingual setting. This year’s lab offered three tasks: Task 1 on multilingual information extraction to extend from last year’s task on French and English corpora to French, Hungarian, and Italian; Task 2 on technologically assisted reviews in empirical medicine building on last year’s pilot task in English; and Task 3 on Consumer Health Search (CHS) in mono- and multilingual settings that builds on the 2013–17 Information Retrieval tasks. In total 28 teams took part in these tasks (14 in Task 1, 7 in Task 2 and 7 in Task 3). Herein, we describe the resources created for these tasks, outline our evaluation methodology adopted and provide a brief summary of participants of this year’s challenges and results obtained. As in previous years, the organizers have made data and tools associated with the lab tasks available for future research and development.
Maynooth University ... arrow_drop_down Maynooth University ePrints & eTheses ArchivePart of book or chapter of book . 2018Data sources: Maynooth University ePrints & eTheses ArchiveNARCIS; Universiteit van Amsterdam (UvA) Institutional Repository UvA-DAREConference object . 2018CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2018Data sources: CORE (RIOXX-UK Aggregator)https://doi.org/10.1007/978-3-...Part of book or chapter of book . Conference object . 2018License: http://www.springer.com/tdmadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-319-98932-7_26&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu25 citations 25 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 4visibility views 4 download downloads 137 Powered bymore_vert Maynooth University ... arrow_drop_down Maynooth University ePrints & eTheses ArchivePart of book or chapter of book . 2018Data sources: Maynooth University ePrints & eTheses ArchiveNARCIS; Universiteit van Amsterdam (UvA) Institutional Repository UvA-DAREConference object . 2018CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2018Data sources: CORE (RIOXX-UK Aggregator)https://doi.org/10.1007/978-3-...Part of book or chapter of book . Conference object . 2018License: http://www.springer.com/tdmadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2009SPIE Edward Davies; Pouneh Saffari; Chengbo Mou; Kaiming Zou; Lin Zhang;doi: 10.1117/12.834906
Poster: The properties of etched large angle tilted gratings (81o) are investigated. The attenuation peaks of the modes are found to shift to shorter wavelengths at a rate of ∼5nm/min in a solution of 10% HF acid. The most sensitive modes are examined for different etching times creating the relationship that longer etching times results in an increase in overall sensitivity. Comparing the sensitivity of the tilted fibre grating, etched for 6 hours, 506.9nm/unri and the most sensitive LPG, period 164μm, 389.2nm/unri in the RI range 1.30-1.40 shows that the produced tilted grating is more sensitive than the LPG and in this range would ideally be suited for the used in Bio-sensing applications.
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . Conference object . 2009add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1117/12.834906&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . Conference object . 2009add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1117/12.834906&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Part of book or chapter of book 2006 United KingdomBMJ Authors: Swaran P. Singh; Tom Burns;Swaran P. Singh; Tom Burns;Some minority ethnic groups in England and Wales have higher rates of admission for mental\ud illness and more adverse pathways to care. Are the resulting accusations of institutional racism\ud within psychiatry justified?
CORE (RIOXX-UK Aggre... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmj.38930.501516.be&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu73 citations 73 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 16visibility views 16 download downloads 341 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmj.38930.501516.be&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Conference object 2021Authors: Eman Omairey; Yuqing Zhang; Ignacio Artamendi; Bob Allen;Eman Omairey; Yuqing Zhang; Ignacio Artamendi; Bob Allen;This study presents research on laboratory production and experimental characterisation of an alternative bitumen using municipal waste plastics. Six different waste plastics (A1 - A6) produced by a local waste recycling manufacturers were selected and characterised to investigate their feasibility in modifying the bitumen binders. Thermal characteristics were firstly obtained using Differential Scanning Calorimetry (DSC) device and the chemical functional groups were identified by Fourier Transform Infrared Spectroscopy (FT-IR) test to determine the plastic types existing in the recycled plastics. Then the rheological properties of the bitumen modified with two nominated plastic waste (A1 and A2) were examined using the Dynamic Shear Rheometer (DSR) device by conducting frequency sweep tests. Additionally, the engineering performance of waste plastics-derived bitumen was also obtained and compared against the control bitumen, including fatigue, rutting and healing performance using Time Sweep (TS) test, Multiple Stress Creep and Recovery (MSCR) test and Healing test, respectively. Results show that A1and A2 consist of low-density polyethene (LDPE) and polypropylene (PP), respectively. The recycled waste plastic A5 and A6 (both classified under the same category but collected from different plants and batches) are mainly consisting of LDPE. Whereas, other recycled plastics (A3 and A4) consist of a variety of materials and impurities. Thus, A1 and A2 were chosen as bitumen binder extenders. A1-modified bitumen exhibited more elastic and less viscous behaviour than the control bitumen, showed by increased shear modulus and reduced phase angle. Whereas, A2 (consisting of PP) caused a significant drop in the shear modulus. Both recycled LDPE and PP-modified bitumen had a substantially improved resistance to rutting and fatigue cracking compared to the control bitumen. Furthermore, waste LDPE-modified bitumen sustained increased healing potential compared to waste PP-modified bitumen, where the latter did not show noticeable improvement to the healing performance.
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2021Data sources: CORE (RIOXX-UK Aggregator)All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_001::0110b235f11d73d9571a586bbcc9c743&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2021Data sources: CORE (RIOXX-UK Aggregator)All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=dedup_wf_001::0110b235f11d73d9571a586bbcc9c743&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2006IEEE Authors: Gansen Zhao; Sassa Otenko; David W. Chadwick;Gansen Zhao; Sassa Otenko; David W. Chadwick;Secure Role Based Messaging (SRBM) augments messaging systems with role oriented communication in a secure manner. Role occupants can sign and decrypt messages on behalf of roles. This paper identifies the requirements of SRBM and recognises the need for: distributed key shares, fast membership revocation, mandatory security controls and detection of identity spoofing. A shared RSA scheme is constructed. RSA keys are shared and distributed to role occupants and role gate keepers. Role occupants and role gate keepers must cooperate together to use the key shares to sign and decrypt the messages. Role occupant signatures can be verified by an audit service. A SRBM system architecture is developed to show the security related performance of the proposed scheme, which also demonstrates the implementation of fast membership revocation, mandatory security control and prevention of spoofing. It is shown that the proposed scheme has successfully coupled distributed security with mandatory security controls to realize secure role based messaging.
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . Conference object . 2006add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/aina.2006.146&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu8 citations 8 popularity Average influence Average impulse Average Powered by BIP!
more_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . Conference object . 2006add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/aina.2006.146&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2013 Germany, Croatia, United Kingdom, United Kingdom, Germany, Norway, United Kingdom, Australia, Netherlands, Sweden, Finland, United KingdomPublic Library of Science (PLoS) WT, CIHR, UKRI | Vitamin D and health: gen...WT ,CIHR ,UKRI| Vitamin D and health: genome-wide analysis and insights from Mendelian randomisation.Benjamin Voight; Guillaume Pare; Ruth Loos; Michael Preuss; Åsa Johansson; Eco De Geus; Michael Weedon; Marjo-Riitta Jarvelin; Joyce Van Meurs; Torben Jørgensen; Kirsi Pietiläinen; Nicole Glazer; Mattias Lorentzon; Braxton Mitchell; Nicole Soranzo; Patricia Munroe; Ozren Polasek; Elisabeth Thiering; Marika Kaakinen; Carla Vogel; Jennie Hui; Elina Hypponen; ROBERTO ELOSUA; Amanda Bennett; Michael Stumvoll; Andrew Hattersley; Peter P Pramstaller; Lambertus Kiemeney; Sophie Visvikis-Siest; Vilmundur Gudnason; John Whittaker; Aroon Hingorani; Thor Aspelund; Dale Nyholt; Mary Feitosa; Vimal Karani; Mika Kähönen; Lachlan Coin; Malcolm Dunlop; Josee Dupuis; Terho Lehtimäki; Peter Visscher; Katja Aben; Daniel Witte; Cyrus Cooper; Stefan Pilz; Willem Ouwehand; Eleanor Wheeler; Peter Kovacs; Debbie A Lawlor; Kevin Jacobs; Evropi Theodoratou; Hana Lango Allen; Rosanda Mulic; Rui Li; Stephen Kritchevsky; Philippe Froguel; Soumya Raychaudhuri; Cornelia Van Duijn; Andrew Wood; Chiara Lanzani; Tonu Esko; Sadaf Farooqi; Reedik Mägi; Gerard Waeber; Claes Ohlsson; André Scherag; Marcus Kleber; Thomas Meitinger; Lina Zgaga; Denise Houston; Karl Michaëlsson; Robert Weyant; Thomas Wang; Paul Elliott; Robert Luben; Albert Vernon Smith; MANUELA UDA; Gonneke Willemsen; Mark McCarthy; Cecilia Lindgren; Olle Melander; Igor Rudan; Maris Teder-Laving; Liesbeth Vandenput;pmid: 23393431
pmc: PMC3564800
Editors' Summary Background Obesity—having an unhealthy amount of body fat—is increasing worldwide. In the US, for example, a third of the adult population is now obese. Obesity is defined as having a body mass index (BMI, an indicator of body fat calculated by dividing a person's weight in kilograms by their height in meters squared) of more than 30.0 kg/m2. Although there is a genetic contribution to obesity, people generally become obese by consuming food and drink that contains more energy than they need for their daily activities. Thus, obesity can be prevented by having a healthy diet and exercising regularly. Compared to people with a healthy weight, obese individuals have an increased risk of developing diabetes, heart disease and stroke, and tend to die younger. They also have a higher risk of vitamin D deficiency, another increasingly common public health concern. Vitamin D, which is essential for healthy bones as well as other functions, is made in the skin after exposure to sunlight but can also be obtained through the diet and through supplements. Why Was This Study Done? Observational studies cannot prove that obesity causes vitamin D deficiency because obese individuals may share other characteristics that reduce their circulating 25-hydroxy vitamin D [25(OH)D] levels (referred to as confounding). Moreover, observational studies cannot indicate whether the larger vitamin D storage capacity of obese individuals (vitamin D is stored in fatty tissues) lowers their 25(OH)D levels or whether 25(OH)D levels influence fat accumulation (reverse causation). If obesity causes vitamin D deficiency, monitoring and treating vitamin D deficiency might alleviate some of the adverse health effects of obesity. Conversely, if low vitamin D levels cause obesity, encouraging people to take vitamin D supplements might help to control the obesity epidemic. Here, the researchers use bi-directional “Mendelian randomization” to examine the direction and causality of the relationship between BMI and 25(OH)D. In Mendelian randomization, causality is inferred from associations between genetic variants that mimic the influence of a modifiable environmental exposure and the outcome of interest. Because gene variants do not change over time and are inherited randomly, they are not prone to confounding and are free from reverse causation. Thus, if a lower vitamin D status leads to obesity, genetic variants associated with lower 25(OH)D concentrations should be associated with higher BMI, and if obesity leads to a lower vitamin D status, then genetic variants associated with higher BMI should be associated with lower 25(OH)D concentrations. What Did the Researchers Do and Find? The researchers created a “BMI allele score” based on 12 BMI-related gene variants and two “25(OH)D allele scores,” which are based on gene variants that affect either 25(OH)D synthesis or breakdown. Using information on up to 42,024 participants from 21 studies, the researchers showed that the BMI allele score was associated with both BMI and with 25(OH)D levels among the study participants. Based on this information, they calculated that each 10% increase in BMI will lead to a 4.2% decrease in 25(OH)D concentrations. By contrast, although both 25(OH)D allele scores were strongly associated with 25(OH)D levels, neither score was associated with BMI. This lack of an association between 25(OH)D allele scores and obesity was confirmed using data from more than 100,000 individuals involved in 46 studies that has been collected by the GIANT (Genetic Investigation of Anthropometric Traits) consortium. What Do These Findings Mean? These findings suggest that a higher BMI leads to a lower vitamin D status whereas any effects of low vitamin D status on BMI are likely to be small. That is, these findings provide evidence for obesity as a causal factor in the development of vitamin D deficiency but not for vitamin D deficiency as a causal factor in the development of obesity. These findings suggest that population-level interventions to reduce obesity should lead to a reduction in the prevalence of vitamin D deficiency and highlight the importance of monitoring and treating vitamin D deficiency as a means of alleviating the adverse influences of obesity on health. Additional Information Please access these Web sites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.1001383. The US Centers for Disease Control and Prevention provides information on all aspects of overweight and obesity (in English and Spanish); a data brief provides information about the vitamin D status of the US population The World Health Organization provides information on obesity (in several languages) The UK National Health Service Choices website provides detailed information about obesity and a link to a personal story about losing weight; it also provides information about vitamin D The International Obesity Taskforce provides information about the global obesity epidemic The US Department of Agriculture's ChooseMyPlate.gov website provides a personal healthy eating plan; the Weight-control Information Network is an information service provided for the general public and health professionals by the US National Institute of Diabetes and Digestive and Kidney Diseases (in English and Spanish) The US Office of Dietary Supplements provides information about vitamin D (in English and Spanish) MedlinePlus has links to further information about obesity and about vitamin D (in English and Spanish) Wikipedia has a page on Mendelian randomization (note: Wikipedia is a free online encyclopedia that anyone can edit; available in several languages) Overview and details of the collaborative large-scale genetic association study (D-CarDia) provide information about vitamin D and the risk of cardiovascular disease, diabetes and related traits Background Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis. Methods and Findings We used information from 21 adult cohorts (up to 42,024 participants) with 12 BMI-related SNPs (combined in an allelic score) to produce an instrument for BMI and four SNPs associated with 25(OH)D (combined in two allelic scores, separately for genes encoding its synthesis or metabolism) as an instrument for vitamin D. Regression estimates for the IVs (allele scores) were generated within-study and pooled by meta-analysis to generate summary effects. Associations between vitamin D scores and BMI were confirmed in the Genetic Investigation of Anthropometric Traits (GIANT) consortium (n = 123,864). Each 1 kg/m2 higher BMI was associated with 1.15% lower 25(OH)D (p = 6.52×10−27). The BMI allele score was associated both with BMI (p = 6.30×10−62) and 25(OH)D (−0.06% [95% CI −0.10 to −0.02], p = 0.004) in the cohorts that underwent meta-analysis. The two vitamin D allele scores were strongly associated with 25(OH)D (p≤8.07×10−57 for both scores) but not with BMI (synthesis score, p = 0.88; metabolism score, p = 0.08) in the meta-analysis. A 10% higher genetically instrumented BMI was associated with 4.2% lower 25(OH)D concentrations (IV ratio: −4.2 [95% CI −7.1 to −1.3], p = 0.005). No association was seen for genetically instrumented 25(OH)D with BMI, a finding that was confirmed using data from the GIANT consortium (p≥0.57 for both vitamin D scores). Conclusions On the basis of a bi-directional genetic approach that limits confounding, our study suggests that a higher BMI leads to lower 25(OH)D, while any effects of lower 25(OH)D increasing BMI are likely to be small. Population level interventions to reduce BMI are expected to decrease the prevalence of vitamin D deficiency. Please see later in the article for the Editors' Summary A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin D levels and obesity.
Europe PubMed Centra... arrow_drop_down HELDA - Digital Repository of the University of HelsinkiArticle . 2013Data sources: HELDA - Digital Repository of the University of HelsinkiUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2013Data sources: Universitätsbibliographie, Universität Duisburg-EssenPublication Server of Helmholtz Zentrum München (PuSH)Article . 2013Data sources: Publication Server of Helmholtz Zentrum München (PuSH)Spiral - Imperial College Digital RepositoryArticle . 2012Data sources: Spiral - Imperial College Digital RepositoryOxford University Research Archive; PLoS Medicine; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2013 . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu874 citations 874 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!
visibility 57visibility views 57 download downloads 250 Powered bymore_vert Europe PubMed Centra... arrow_drop_down HELDA - Digital Repository of the University of HelsinkiArticle . 2013Data sources: HELDA - Digital Repository of the University of HelsinkiUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2013Data sources: Universitätsbibliographie, Universität Duisburg-EssenPublication Server of Helmholtz Zentrum München (PuSH)Article . 2013Data sources: Publication Server of Helmholtz Zentrum München (PuSH)Spiral - Imperial College Digital RepositoryArticle . 2012Data sources: Spiral - Imperial College Digital RepositoryOxford University Research Archive; PLoS Medicine; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2013 . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2013add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 2019Springer International Publishing EC | SUPERAID7EC| SUPERAID7Cristina Medina-Bailon; Toufik Sadi; Carlos Sampedro; José-Luis Padilla; Luca Donetti; Vihar P. Georgiev; Francisco Gamiz; Asen Asenov;From a modeling point of view, the inclusion of adequate physical phenomena is mandatory when analyzing the behavior of new transistor architectures. In particular, the high electric field across the ultra-thin insulator in aggressively scaled transistors leads to the possibility for the charge carriers in the channel to tunnel through the gate oxide via various gate leakage mechanisms (GLMs). In this work, we study the impact of trap number on gate leakage using the GLM model, which is included in a Multi-Subband Ensemble Monte Carlo (MS-EMC) simulator for Fully-Depleted Silicon-On-Insulator (FDSOI) field effect transistors (FETs). The GLM code described herein considers both direct and trap-assisted tunneling. This work shows that trap attributes and dynamics can modify the device electrostatic characteristics and even play a significant role in determining the extent of GLMs.
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2019Data sources: CORE (RIOXX-UK Aggregator)https://doi.org/10.1007/978-3-...Part of book or chapter of book . 2019License: http://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
download 14download downloads 14 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2019Data sources: CORE (RIOXX-UK Aggregator)https://doi.org/10.1007/978-3-...Part of book or chapter of book . 2019License: http://www.springer.com/tdmData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Part of book or chapter of book 2001 EnglishOperational Research Society FCT | LA 1, FCT | LA 5FCT| LA 1 ,FCT| LA 5Alifantis, A.; Robinson, S.; Edwards, J.; Hurrion, R.; Ladbrook, J.; Waller, T.;CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2001Data sources: CORE (RIOXX-UK Aggregator)All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=core_ac_uk__::99657ce490972f661d5abae7f0569835&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
visibility 2visibility views 2 download downloads 60 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . 2001Data sources: CORE (RIOXX-UK Aggregator)All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=core_ac_uk__::99657ce490972f661d5abae7f0569835&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2016ACM Press Sergio Gutierrez-Santos; Stefano Capuzzi; Ken Kahn; Sokratis Karkalas; Alexandra Poulovassilis;We present and evaluate a web-based architecture for monitoring student-system interaction indicators in Exploratory Learning Environments (ELEs), using as our case study a microworld for secondary school algebra. We discuss the challenging role of teachers in exploratory learning settings and motivate the need for visualisation and notification tools that can assist teachers in focusing their attention across the class and inform teachers' interventions. We present an architecture that can support such Teacher Assistance tools and demonstrate its scalability to allow concurrent usage by thousands of users (students and teachers).
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . Conference object . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1145/2872518.2891075&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu2 citations 2 popularity Average influence Average impulse Average Powered by BIP!
more_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Part of book or chapter of book . Conference object . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 2022 FinlandSpringer International Publishing