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No abstract available.

No abstract available.

Mapping is proposed as a method to overcome universalist and Eurocentric assumptions in music historiography and arrive at more cosmopolitan conceptions. The chapter is accompanied by two maps produced with GIS (Geographic Information System) software, showing membership (by entry date) of the International Society for Contemporary Music (ISCM), the diffusion of dodecaphony (by the date of the first verified dodecaphonic composition by country) and the founding of conservatoires across the globe. The maps’ creation further involved the use of crowdsourcing. The opportunities and limitations of mapping are discussed both in relation to the concrete examples and the method in general.

The years of ‘happy scaling’ are over and the fundamental challenges that the semiconductor industry faces, at both technology and device level, will impinge deeply upon the design of future integrated circuits and systems. This paper provides an introduction to these challenges and gives an overview of the Grid infrastructure that will be developed as part of a recently funded EPSRC pilot project to address them, and we hope, which will revolutionise the electronics design industry.

This chapter considers the relationship between intellectuals and cultural policies, in particular in the role played by various categories of ‘expert’ in the production of the official discourse on creativity that now occupies the conceptual high ground and has effectively displaced — or at least obscured — the discourse on the cultural industries.1

This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and experimental data was demonstrated, since very little information is currently available to guide the selection of parameter values for the models. This paper presents a model validating method using both multiple experimental data and global optimization.

A programme note/essay commissioned for the first production of Ella Hickson's play, The Writer, staged at the Almeida Theatre, London, in April 2018.

Experimental and theoretical studies have shown the importance of stochastic processes in genetic regulatory networks and cellular processes. Cellular networks and genetic circuits often involve small numbers of key proteins such as transcriptional factors and signaling proteins. In recent years stochastic models have been used successfully for studying noise in biological pathways, and stochastic modelling of biological systems has become a very important research field in computational biology. One of the challenge problems in this field is the reduction of the huge computing time in stochastic simulations. Based on the system of the mitogen-activated protein kinase cascade that is activated by epidermal growth factor, this work give a parallel implementation by using OpenMP and parallelism across the simulation. Special attention is paid to the independence of the generated random numbers in parallel computing, that is a key criterion for the success of stochastic simulations. Numerical results indicate that parallel computers can be used as an efficient tool for simulating the dynamics of large-scale genetic regulatory networks and cellular processes.

No abstract available.