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  • Open Access English
    Authors: 
    David Doran; Marc Rodriguez-Garcia; Rebecca Turk-MacLeod; Geoffrey J. T. Cooper; Leroy Cronin;
    Publisher: Beilstein-Institut
    Country: United Kingdom
    Project: UKRI | Programmable Molecular Me... (EP/J015156/1), EC | SMART-POM (670467), EC | EVOBLISS (611640)

    We propose that a chemically agnostic approach to explore the origin of life, using an automated recursive platform based on droplet microfluidics, could be used to induce artificial chemical evolution by iterations of growth, speciation, selection, and propagation. To ...

  • Open Access English
    Authors: 
    Rupert Bauersachs; Olivia Wu; Jean-Baptiste Briere; Kevin Bowrin; K. Borkowska; Anna Jakubowska; Vanessa Taieb; Mondher Toumi; Maria Huelsebeck;
    Publisher: Hindawi
    Country: United Kingdom

    Aims. Acetylsalicylic acid (ASA) is widely used for the prevention of atherothrombotic events in patients with chronic coronary artery disease (CAD) and peripheral artery disease (PAD), but the risk of vascular events remains high. We aimed at identifying randomised con...

  • Open Access English
    Authors: 
    Meng, Lin; Porr, Bernd; Gollee, Henrik;
    Publisher: Yiqi Yibiao Xuebao Zazhishe
    Country: United Kingdom

    The work presents a review on the technological advancements of functional electrical stimulation (FES) neuroprostheses\ud to restore gait walking over the last decades. The aim of an FES intervention is to functionally restore and rehabilitate individuals with\ud motor...

  • Publication . Article . Other literature type . 2020
    Open Access English
    Authors: 
    Douglas H. Smith; William Stewart;
    Publisher: Nature Research
    Country: United Kingdom

    Mortality from neurodegenerative disease is high among professional soccer players, potentially associated with repeated head impacts during routine gameplay. New data suggest that the apolipoprotein E ε4 allele might exacerbate the effects of soccer ball heading on cog...

  • Open Access English
    Authors: 
    Welden, Natalie; Lusher, Amy L.;
    Publisher: Wiley
    Country: United Kingdom

    Marine plastic pollution is currently a major scientific focus, with attention paid to its distribution and impacts within ecosystems. With recent estimates indicating that the mass of plastic released to the marine environment may reach 250 million metric tons by 2025,...

  • Open Access English
    Authors: 
    Ricciardi, Lorenzo; Maddock, Christie; Vasile, Massimiliano;
    Country: United Kingdom

    This paper presents a multi-objective trajectory optimisation under uncertainty for the\ud ascent of a two-stage, semi-reusable space launch system. Using Orbital Access' Orbital 500-R launcher as a test case, robust multi-disciplinary design optimisation is used to ana...

  • Open Access English
    Authors: 
    Pinter, Daniela; Ritchie, Stuart J.; Doubal, Fergus; Gattringer, Thomas; Morris, Zoe; Bastin, Mark E.; del C. Valdés Hernández, Maria; Royle, Natalie A.; Corley, Janie; Muñoz Maniega, Susana; +9 more
    Countries: Netherlands, United Kingdom
    Project: FWF | Longitudinal RS fMRI &amp... (T 690), UKRI | Centre for Cognitive Agei... (MR/K026992/1)

    Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain gait and balance function in the elderly. We analysed 678 community-dwelling healthy subject...

  • Open Access
    Authors: 
    Jessica G. Borger; Vicky L. Morrison; Andrew Filby; Celine Garcia; Liisa M. Uotila; Fabio Simbari; Susanna C. Fagerholm; Rose Zamoyska;
    Publisher: The American Association of Immunologists
    Countries: Finland, United Kingdom
    Project: WT | Mechanisms that regulate ... (096669)

    T cell receptor (TCR) stimulation by pMHC complexes on antigen presenting cells (APC), requires precise re-organisation of molecules into the area of cellular contact to form an immunological synapse from where T cell signaling is initiated. Caveolin-1 (Cav1), a widely ...

  • Open Access English
    Authors: 
    Meena Murthy; Thimo Kurz; Kevin M. O'Shaughnessy;
    Publisher: Springer International Publishing
    Country: United Kingdom

    Hypertension (high blood pressure) is a major public health problem affecting more than a billion people worldwide with complications, including stroke, heart failure and kidney failure. The regulation of blood pressure is multifactorial reflecting genetic susceptibilit...

  • Open Access English
    Authors: 
    Gerasimos Tsourapas;
    Publisher: Wiley
    Country: United Kingdom
    Project: EC | MAGYC (822806)

    No abstract available.