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1,671 research outcomes, page 1 of 168
  • publication . Article . 2012
    Open Access English
    Authors:
    Andrea Doeschl-Wilson; Steve C. Bishop; Ilias Kyriazakis; Beatriz Villanueva;
    Publisher: Frontiers Media S.A.

    We propose two novel approaches for describing and quantifying the response of individual hosts to pathogen challenge in terms of infection severity and impact on host performance. The first approach is a direct extension of the methodology for estimating group toleranc...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Georg eBasler; Evangelos eSimeonidis; Evangelos eSimeonidis;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: EC | PSEUDOMODEL (329682)

    Peer reviewed

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  • publication . Article . 2019
    Open Access
    Authors:
    You Cai; You Cai; Yufen Zhang; Yufen Zhang; Xiao Ke; Xiao Ke; Yu Guo; Chengye Yao; Na Tang; Pei Pang; ...
    Persistent Identifiers
    Publisher: Frontiers Media SA

    Ischemic stroke, which accounts for 87% of all strokes, constitutes the leading cause of morbidity and mortality in China. Although the genetics and epigenetics of stroke have been extensively investigated, few studies have examined their relationships at different stag...

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  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Serge Nataf; Serge Nataf; Serge Nataf; Juan Uriagereka; Antonio Benitez-Burraco;
    Publisher: Frontiers Media S.A.

    ABSTRACTSocial behavior and neuronal connectivity in rodents have been shown to be shaped by the prototypical T lymphocyte-derived pro-inflammatory cytokine Interferon-gamma (IFNγ). It has also been demonstrated that STAT1 (Signal Transducer And Activator Of Transcripti...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Charmaine S. Tam; Jeffrey D. Covington; Eric Ravussin; Leanne M. Redman;
    Persistent Identifiers
    Publisher: Frontiers Research Foundation
    Project: NIH | Metabolic Adaptations to ... (3U01AG020478-06S1), NIH | Core--Molecular Mechanism... (5P30DK072476-05), NIH | Effects of weight and ins... (5K99HD060762-02)

    Context: The effect of weight loss by diet alone or diet in conjunction with exercise on low-grade inflammation in non-obese (overweight) individuals is not known. Objective: Test the hypothesis that 24 weeks of moderate calorie restriction (CR; 25%) by diet only or wit...

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  • publication . Article . Preprint . Other literature type . 2019
    Open Access English
    Authors:
    Nikola Simidjievski; Cristian Bodnar; Ifrah Tariq; Paul Scherer; Helena Andrés-Terré; Zohreh Shams; Mateja Jamnik; Pietro Liò;
    Publisher: Frontiers Media S.A.

    International initiatives such as the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), Cancer Genome Atlas (TCGA), and the International Cancer Genome Consortium (ICGC) are collecting multiple data sets at different genome-scales with the aim to ...

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  • publication . Article . 2020
    Open Access
    Authors:
    Mursal Sherzai; Adamo Valle; Adamo Valle; Nicholas Perry; Ester Kalef-Ezra; Sahar Al-Mahdawi; Mark Pook; Sara Anjomani Virmouni;
    Persistent Identifiers
    Publisher: Frontiers Media SA

    Copyright © 2020 Sherzai, Valle, Perry, Kalef-Ezra, Al-Mahdawi, Pook and Anjomani Virmouni. Friedreich’s ataxia (FRDA) is a progressive neurodegenerative disorder caused by a homozygous GAA repeat expansion mutation in intron 1 of the frataxin gene (FXN), which instigat...

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  • publication . Article . 2018
    Open Access
    Authors:
    Jessica Duis; Olivia Cox; Yuelong Ji; Fayaz Seifuddin; Richard S. Lee; Xiaobin Wang;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: NIH | Gene Polymorphism, Infect... (7R01HD041702-04), NIH | Epigenome-wide Associatio... (7R21HD066471-02), NIH | Molecular Epidemiology of... (5R21ES011666-02)

    A single nucleotide polymorphism (SNP: rs1360780) in FKBP5 (FK506 Binding Protein 5) has been shown to interact with exposure to childhood adversity to promote loss of methylation and increase in gene expression in adults. We asked whether rs1360780 can influence FKBP5 ...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Megan K. Mulligan; Wenyuan Zhao; Morgan Dickerson; Danny Arends; Pjotr Prins; Sonia A. Cavigelli; Elena Terenina; Pierre Mormède; Lu Lu; Byron C. Jones;
    Publisher: Frontiers Media SA
    Project: NIH | Genetic Analysis of Ethan... (5U01AA014425-02), NIH | Genetics of Chronic Mild ... (5R01AA021951-03)

    International audience; We profiled individual differences in alcohol consumption upon initial exposure and during 5 weeks of voluntary alcohol intake in female mice from 39 BXD recombinant inbred strains and parents using the drinking in the dark (DID) method. In this ...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Urko M. Marigorta; Greg Gibson;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: NIH | Analysis of rare variants... (5P01GM099568-02)

    The switch to a modern lifestyle in recent decades has coincided with a rapid increase in prevalence of obesity and other diseases. These shifts in prevalence could be explained by the release of genetic susceptibility for disease in the form of gene-by-environment (GxE...

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1,671 research outcomes, page 1 of 168