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60 research outcomes, page 1 of 6
  • publication . Article . 2012
    Open Access
    Authors:
    Evgeny Yurkovsky; Iftach Nachman;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    The timing of a cellular event often hides critical information on the process leading to the event. Our ability to measure event times in single cells along with other quantities allow us to learn about the drivers of the timed process and its downstream effects. In th...

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  • publication . Article . 2018
    Open Access
    Authors:
    Howard Ochman;
    Publisher: Elsevier BV

    The evolution of higher plants depended on the ability of cells to express hereditary information in many different ways and led to the development of specialized cell types, reflecting an elaborate system of control over gene expression in the individual component cell...

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  • publication . Article . 2015
    Open Access
    Authors:
    Clara Lopes Novo; Peter J. Rugg-Gunn;
    Publisher: Oxford University Press (OUP)
    Project: WT | Epigenetic and Signal Tra... (093736), EC | EPIGENESYS (257082)

    Translating the vast amounts of genomic and epigenomic information accumulated on the linear genome into three-dimensional models of nuclear organization is a current major challenge. In response to this challenge, recent technological innovations based on chromosome co...

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  • publication . Article . 2012
    Open Access
    Authors:
    Sevil Sofueva; Suzana Hadjur;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    A comprehensive description of the complex three-dimensional organization of our genome and of the protein complexes mediating this organization is required in order to fully appreciate the regulation of gene activity contained within it. This review will focus on the e...

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  • publication . Article . 2013
    Open Access
    Authors:
    Gonçalo Castelo-Branco; Andrew J. Bannister;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
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  • publication . Article . 2017
    Open Access English
    Authors:
    Dean C. Semmens; Maurice R. Elphick;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: UKRI | Neuropeptide function in ... (BB/M001644/1)

    Abstract Neuropeptides are evolutionarily ancient mediators of neuronal signalling that regulate a wide range of physiological processes and behaviours in animals. Neuropeptide signalling has been investigated extensively in vertebrates and protostomian invertebrates, w...

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  • publication . Other literature type . Article . 2017
    Open Access English
    Authors:
    Mark Viney;
    Publisher: Oxford University Press
    Project: WT

    Nematodes are highly abundant animals, and many species have a parasitic lifestyle. Nematode parasites are important pathogens of humans and other animals, and there is considerable interest in understanding their molecular and genomic adaptations to nematode parasitism...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Richard P. Halley-Stott; John B. Gurdon;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: WT , UKRI | Identification of chromos... (G1001690)

    Epigenetic memory represents a natural mechanism whereby the identity of a cell is maintained through successive cell cycles, allowing the specification and maintenance of differentiation during development and in adult cells. Cancer is a loss or reversal of the stable ...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Sophia Ananiadou; Paul Thompson; Raheel Nawaz; John McNaught; Douglas B. Kell;
    Persistent Identifiers
    Project: WT , UKRI | Supporting Evidence-based... (MR/L01078X/1)

    The assessment of genome function requires a mapping between genome-derived entities and biochemical reactions, and the biomedical literature represents a rich source of information about reactions between biological components. However, the increasingly rapid growth in...

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  • publication . Article . 2013
    Open Access
    Authors:
    Paulo P. Amaral; Marcel E. Dinger; John S. Mattick;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Cells and organisms are subject to challenges and perturbations in their environment and physiology in all stages of life. The molecular response to such changes, including insulting conditions such as pathogen infections, involves coordinated modulation of gene express...

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60 research outcomes, page 1 of 6