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  • Open Access English
    Authors: 
    Kay, Rebecca; Trevena, Paulina;
    Publisher: Policy Press
    Country: United Kingdom

    No abstract available.

  • Open Access English
    Authors: 
    Tianhai Tian; Kevin Burrage;
    Publisher: IEEE Computer Society
    Country: United Kingdom

    Experimental and theoretical studies have shown the importance of stochastic processes in genetic regulatory networks and cellular processes. Cellular networks and genetic circuits often involve small numbers of key proteins such as transcriptional factors and signaling proteins. In recent years stochastic models have been used successfully for studying noise in biological pathways, and stochastic modelling of biological systems has become a very important research field in computational biology. One of the challenge problems in this field is the reduction of the huge computing time in stochastic simulations. Based on the system of the mitogen-activated protein kinase cascade that is activated by epidermal growth factor, this work give a parallel implementation by using OpenMP and parallelism across the simulation. Special attention is paid to the independence of the generated random numbers in parallel computing, that is a key criterion for the success of stochastic simulations. Numerical results indicate that parallel computers can be used as an efficient tool for simulating the dynamics of large-scale genetic regulatory networks and cellular processes.

  • Publication . Part of book or chapter of book . 2019
    Open Access English
    Authors: 
    Evans, Jonathan;
    Publisher: Routledge
    Country: United Kingdom

    No abstract available.

  • Open Access
    Authors: 
    Kim, J.; Kim, J. -S; Postlethwaite, I.; J.S. (Pat) Heslop-Harrison; Bates, D. G.;
    Country: United Kingdom

    This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and experimental data was demonstrated, since very little information is currently available to guide the selection of parameter values for the models. This paper presents a model validating method using both multiple experimental data and global optimization.

  • Publication . Part of book or chapter of book . 2015
    Open Access
    Authors: 
    Schlesinger, Philip;
    Publisher: Palgrave Macmillan UK
    Country: United Kingdom

    This chapter considers the relationship between intellectuals and cultural policies, in particular in the role played by various categories of ‘expert’ in the production of the official discourse on creativity that now occupies the conceptual high ground and has effectively displaced — or at least obscured — the discourse on the cultural industries.1

  • Publication . Part of book or chapter of book . 2009
    Open Access
    Authors: 
    Jongrae Kim; Declan G. Bates;
    Publisher: The MIT Press
    Country: United Kingdom

    No abstract available.

  • Publication . Part of book or chapter of book . 2020
    Open Access English
    Authors: 
    Glen Pettigrove;
    Publisher: Cambridge University Press
    Country: United Kingdom

    Ethicists often approach our task by thinking about the norms that apply to act types. We ask, for example, what it means to punish, to make amends, or to forgive, and what conditions govern the appropriate performance of actions that fall within these types. However, actions often do not fall neatly into only one action type. This chapter discusses two cases that can be interpreted both as acts of protest and as acts of what Linda Radzik calls “informal social punishment.” Since the norms that govern these two types diverge, the fact that a particular action can be interpreted in either of these ways poses a challenge for anyone who might be seeking moral guidance from the type to which the action belongs. The cases highlight a theoretical gap that needs to be filled not only by accounts of social punishment or protest but also by ethicists who would use this approach to think about actions of other overlapping types.

  • Publication . Part of book or chapter of book . Other literature type . 2021
    Open Access
    Authors: 
    Imperiale, Maria Grazia;
    Publisher: Bristol University Press
    Country: United Kingdom

    This chapter discusses how participatory methodologies (specifically, a critical participatory action research cycle involving planning, action, observation, and reflection) were developed in an online research project on critical English language education in a context of protracted crisis, in the Gaza Strip (Palestine). The impediments to research imposed by the COVID-19 global pandemic are nothing new to the Gaza Strip, which has been under blockade since 2007, impacting Gazans’ mental and physical wellbeing, affecting Gazan academics participation in international networks and collaborative partnerships and obstructing the flow of knowledge, books and teaching materials. Critical, creative and localised pedagogies enabled UK-based researchers and pre-service, secondary school English teachers based in the Gaza Strip to jointly develop, trial and evaluate teaching materials and lesson plans.

  • Publication . Part of book or chapter of book . 2019
    Open Access English
    Authors: 
    Bjorn Heile;
    Publisher: Routledge
    Country: United Kingdom

    Mapping is proposed as a method to overcome universalist and Eurocentric assumptions in music historiography and arrive at more cosmopolitan conceptions. The chapter is accompanied by two maps produced with GIS (Geographic Information System) software, showing membership (by entry date) of the International Society for Contemporary Music (ISCM), the diffusion of dodecaphony (by the date of the first verified dodecaphonic composition by country) and the founding of conservatoires across the globe. The maps’ creation further involved the use of crowdsourcing. The opportunities and limitations of mapping are discussed both in relation to the concrete examples and the method in general.

  • Publication . Part of book or chapter of book . 2016
    Open Access English
    Authors: 
    Paul, Nicholas L.; Schenk, Jochen G.;
    Publisher: Routledge
    Country: United Kingdom

    No abstract available.

search
Include:
1,401 Research products, page 1 of 141
  • Open Access English
    Authors: 
    Kay, Rebecca; Trevena, Paulina;
    Publisher: Policy Press
    Country: United Kingdom

    No abstract available.

  • Open Access English
    Authors: 
    Tianhai Tian; Kevin Burrage;
    Publisher: IEEE Computer Society
    Country: United Kingdom

    Experimental and theoretical studies have shown the importance of stochastic processes in genetic regulatory networks and cellular processes. Cellular networks and genetic circuits often involve small numbers of key proteins such as transcriptional factors and signaling proteins. In recent years stochastic models have been used successfully for studying noise in biological pathways, and stochastic modelling of biological systems has become a very important research field in computational biology. One of the challenge problems in this field is the reduction of the huge computing time in stochastic simulations. Based on the system of the mitogen-activated protein kinase cascade that is activated by epidermal growth factor, this work give a parallel implementation by using OpenMP and parallelism across the simulation. Special attention is paid to the independence of the generated random numbers in parallel computing, that is a key criterion for the success of stochastic simulations. Numerical results indicate that parallel computers can be used as an efficient tool for simulating the dynamics of large-scale genetic regulatory networks and cellular processes.

  • Publication . Part of book or chapter of book . 2019
    Open Access English
    Authors: 
    Evans, Jonathan;
    Publisher: Routledge
    Country: United Kingdom

    No abstract available.

  • Open Access
    Authors: 
    Kim, J.; Kim, J. -S; Postlethwaite, I.; J.S. (Pat) Heslop-Harrison; Bates, D. G.;
    Country: United Kingdom

    This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and experimental data was demonstrated, since very little information is currently available to guide the selection of parameter values for the models. This paper presents a model validating method using both multiple experimental data and global optimization.

  • Publication . Part of book or chapter of book . 2015
    Open Access
    Authors: 
    Schlesinger, Philip;
    Publisher: Palgrave Macmillan UK
    Country: United Kingdom

    This chapter considers the relationship between intellectuals and cultural policies, in particular in the role played by various categories of ‘expert’ in the production of the official discourse on creativity that now occupies the conceptual high ground and has effectively displaced — or at least obscured — the discourse on the cultural industries.1

  • Publication . Part of book or chapter of book . 2009
    Open Access
    Authors: 
    Jongrae Kim; Declan G. Bates;
    Publisher: The MIT Press
    Country: United Kingdom

    No abstract available.

  • Publication . Part of book or chapter of book . 2020
    Open Access English
    Authors: 
    Glen Pettigrove;
    Publisher: Cambridge University Press
    Country: United Kingdom

    Ethicists often approach our task by thinking about the norms that apply to act types. We ask, for example, what it means to punish, to make amends, or to forgive, and what conditions govern the appropriate performance of actions that fall within these types. However, actions often do not fall neatly into only one action type. This chapter discusses two cases that can be interpreted both as acts of protest and as acts of what Linda Radzik calls “informal social punishment.” Since the norms that govern these two types diverge, the fact that a particular action can be interpreted in either of these ways poses a challenge for anyone who might be seeking moral guidance from the type to which the action belongs. The cases highlight a theoretical gap that needs to be filled not only by accounts of social punishment or protest but also by ethicists who would use this approach to think about actions of other overlapping types.

  • Publication . Part of book or chapter of book . Other literature type . 2021
    Open Access
    Authors: 
    Imperiale, Maria Grazia;
    Publisher: Bristol University Press
    Country: United Kingdom

    This chapter discusses how participatory methodologies (specifically, a critical participatory action research cycle involving planning, action, observation, and reflection) were developed in an online research project on critical English language education in a context of protracted crisis, in the Gaza Strip (Palestine). The impediments to research imposed by the COVID-19 global pandemic are nothing new to the Gaza Strip, which has been under blockade since 2007, impacting Gazans’ mental and physical wellbeing, affecting Gazan academics participation in international networks and collaborative partnerships and obstructing the flow of knowledge, books and teaching materials. Critical, creative and localised pedagogies enabled UK-based researchers and pre-service, secondary school English teachers based in the Gaza Strip to jointly develop, trial and evaluate teaching materials and lesson plans.

  • Publication . Part of book or chapter of book . 2019
    Open Access English
    Authors: 
    Bjorn Heile;
    Publisher: Routledge
    Country: United Kingdom

    Mapping is proposed as a method to overcome universalist and Eurocentric assumptions in music historiography and arrive at more cosmopolitan conceptions. The chapter is accompanied by two maps produced with GIS (Geographic Information System) software, showing membership (by entry date) of the International Society for Contemporary Music (ISCM), the diffusion of dodecaphony (by the date of the first verified dodecaphonic composition by country) and the founding of conservatoires across the globe. The maps’ creation further involved the use of crowdsourcing. The opportunities and limitations of mapping are discussed both in relation to the concrete examples and the method in general.

  • Publication . Part of book or chapter of book . 2016
    Open Access English
    Authors: 
    Paul, Nicholas L.; Schenk, Jochen G.;
    Publisher: Routledge
    Country: United Kingdom

    No abstract available.

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