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268,698 research outcomes, page 1 of 26,870
  • publication . Article . 2018
    Open Access English
    Authors:
    Daniel Gonzalez; Amber L. Beitelshees; John G. Gums; Mohamed H. Shahin; Rhonda M. Cooper-DeHoff; Stephen T. Turner; Arlene B. Chapman; Maximilian T. Lobmeyer; Yan Gong; Daniela J. Conrado; ...
    Persistent Identifiers
    Publisher: John Wiley and Sons Inc.
    Project: NIH | Mayo Clinic Center for Cl... (5UL1TR000135-08), NIH | UF Clinical and Translati... (3UL1TR000064-05S2), NIH | Atlanta Clinical and Tran... (5UL1TR000454-07), NIH | Parent Project (2U01GM074492-06), NIH | Use of Physiologically-Ba... (5K23HD083465-02)

    Background For many indications, the negative chronotropic effect of β‐blockers is important to their efficacy, yet the heart rate (HR) response to β‐blockers varies. Herein, we sought to use a genome‐wide association approach to identify novel single nucleotide polymor...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Melissa L. Kemp; Melissa L. Kemp; Margaret A. Gran; Gaurav Dwivedi; Pritha Bagchi;
    Persistent Identifiers
    Publisher: Public Library of Science
    Project: NIH | Redox regulation of cellu... (1DP2OD006483-01)

    Quantifying the magnitude and dynamics of protein oxidation during cell signaling is technically challenging. Computational modeling provides tractable, quantitative methods to test hypotheses of redox mechanisms that may be simultaneously operative during signal transd...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Katrina Mark; Steven B. Smith; Michael S. Humphrys; Alison Schaefer; Vonetta L. Edwards; Bing Ma; Jeanne Tamarelle; Larry J. Forney; Mishka Terplan; Pawel Gajer; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Project: NIH | The Microbial Ecology of ... (3UH2AI083264-01S1), NIH | Chlamydial Pathogeneis in... (5U19AI084044-03)

    ABSTRACT The mechanism(s) by which Lactobacillus-dominated cervicovaginal microbiota provide a barrier to Chlamydia trachomatis infection remain(s) unknown. Here we evaluate the impact of different Lactobacillus spp. identified via culture-independent metataxonomic anal...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Husain Yar Khan; Shafquat Azim; Aamir Ahmad; Daocheng Wu; Mohammad Fahad Ullah; Haseeb Zubair; S.M. Hadi; Ajay P. Singh;
    Persistent Identifiers
    Publisher: MDPI AG
    Project: NIH | Targeting tumor-stromal i... (5R01CA175772-03), NIH | Molecular determinant of ... (5U01CA185490-05)

    There is compelling evidence that serum, tissue and intracellular levels of copper are elevated in all types of cancer. Copper has been suggested as an important co-factor for angiogenesis. It is also a major metal ion present inside the nucleus, bound to DNA bases, par...

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  • publication . Article . 2013
    Open Access
    Authors:
    Patrick McNees; Isabel C. Scarinci; Yu-Mei Schoenberger; Mohammed Omar Mohiuddin; Janice M. Phillips;
    Persistent Identifiers
    Publisher: JMIR Publications Inc.
    Project: NIH | Participatory Design of a... (1R03CA154068-01)

    BackgroundCommunication technologies can play a significant role in decreasing communication inequalities and cancer disparities by promoting cancer control and enhancing population and individual health. Studies have shown that technology, such as the mobile phone shor...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Dae-Sung eKim; P Joel Ross; Kirill eZaslavsky; Kirill eZaslavsky; James eEllis; James eEllis;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Project: CIHR , NIH | Patient iPS cells with Co... (4R33MH087908-03)

    Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder characterized by deficits in social communication, and restricted and repetitive patterns of behavior. Despite its high prevalence, discovery of pathophysiological mechanisms underlying ASD has...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Kornelia Edes; Therese S. Berry; Michelle W. Done; Timothy L. Mosbruger; Wade S. Samowitz; Vahid Khoddami; Vahid Khoddami; Daniel G. Luba; Sue Hammoud; Sue Hammoud; ...
    Persistent Identifiers
    Publisher: Public Library of Science
    Project: NIH | Targeting Genetic and Met... (1ZIABC011648-01), NIH | MOLECULAR AND CELLULAR BI... (1P01CA073992-01A1)

    Background Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. T...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Qian Liu; Atlas Khan; Kai Wang; Kai Wang;
    Publisher: BioMed Central
    Project: NIH | Transcriptional and Epige... (5U01MH103339-02), NIH | Identifying therapeutic t... (5R01MH093725-04), NIH | Establishing comprehensiv... (1R21MH102791-01A1), NIH | Cis-Regulatory Epigenome ... (5U01MH103392-03), NIH | RNA Sequencing of the Lim... (5R01MH105898-04), NIH | 1/3-Networks from Multidi... (5R01MH097276-03), NIH | Decoding schizophrenia-Fr... (5R01MH105472-03), NIH | The USC PsychENCODE Proje... (5U01MH103346-02), NIH | Data and Biostatistics (1P50MH096891-01), NIH | Epigenetic and Transcript... (5R01MH094714-02),...

    Background A range of rare and common genetic variants have been discovered to be potentially associated with mental diseases, but many more have not been uncovered. Powerful integrative methods are needed to systematically prioritize both variants and genes that confer...

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  • publication . Other literature type . Preprint . Article . 2018
    Open Access
    Authors:
    Donghwan Kim; Jeffrey A. Fessler;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Accelerated statistical i... (5U01EB018753-03)

    Abstract First-order methods with momentum, such as Nesterov’s fast gradient method, are very useful for convex optimization problems, but can exhibit undesirable oscillations yielding slow convergence rates for some applications. An adaptive restarting scheme can impro...

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  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    David A. Bennett;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: NIH | Risk Factors, Pathology, ... (5R01AG015819-07), NIH | Pathway discovery, valida... (7U01AG046152-05), NIH | SHORT-TERM STABILITY OF C... (1P30AG010161-01), NIH | Epidemiologic Study of Ne... (3R01AG017917-11A1S1)

    In a Perspective, David Bennett makes a case for neural reserve to be considered as a therapeutic endpoint in clinical trials for dementia.

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268,698 research outcomes, page 1 of 26,870