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  • Publication . Part of book or chapter of book . Conference object . Other literature type . Article . 2016
    Open Access English
    Authors: 
    Florent Berthaut; Luke Dahl;
    Publisher: HAL CCSD
    Country: France
    Project: EC | IXMI (330770)

    International audience; Orchestras of Digital Musical Instruments (DMIs) enable new musical collaboration possibilities, extending those of acoustic and electric orchestras. However the creation and development of these orchestras remain constrained. In fact, each new musical collaboration system or orchestra piece relies on a fixed number of musicians, a fixed set of instruments (often only one), and a fixed subset of possible modes of collaboration. In this paper, we describe a unified framework that enables the design of Digital Orchestras with potentially different DMIs and an expand-able set of collaboration modes. It relies on research done on analysis and classification of traditional and digital orchestras, on research in Collaborative Virtual Environments, and on interviews of musicians and composers. The BOEUF framework consists of a classification of modes of collaboration and a set of components for modelling digital orchestras. Integrating this framework into DMIs will enable advanced musical collaboration modes to be used in any digital orchestra, including spontaneous jam sessions.

  • Publication . Part of book or chapter of book . 2018
    Closed Access
    Authors: 
    Thierry Billard; François Liger; Mathieu Verdurand;
    Publisher: Elsevier
    Country: France

    Abstract The serotonergic system plays a key modulatory role in the brain. This system is critical in many drug developments for brain disorders via interactions with the 14 subtypes of 5-HT receptors or through reuptake blockade. Positron emission tomography (PET) is an efficient tool for in vivo studies of physiological and pathological processes. Because of its pertinent radiochemical properties, fluorine-18 is one of the most used radioisotopes in PET imaging. This chapter will propose an overview of the 18F-radioligands targeting serotonin receptors, which have been developed over the last few years. Both radiosyntheses and pharmacological properties of these radiotracers will be described, with a specific emphasis on their potential medical applications.

  • Publication . Article . Part of book or chapter of book . 2020
    Open Access English
    Authors: 
    Hassen Nigatu; Yimesker Yihun;
    Publisher: HAL CCSD
    Country: France

    International audience; This study presents an algebraic method to detect, count, and identify concomitant motions of parallel robots at the velocity level. The pose and orientation of moving platform of parallel manipulators (PMs) with f-DOF could be commonly described by f possible motion variables on the instantaneous motion space (IMS) and (6 − f) restriction motion variables on the instantaneous restriction space (IRS). However, in some situations, PMs moving platform may accompanied by a concomitant (parasitic) motions along the direction of restriction space. Therefore, the commonly understood one-to-one correspondence between joint space and task space mobility of non-redundant PMs would be compromised. This phenomenon occurred due to the fact that the alignment of screws can change the reciprocal screws while the given screw systems are still maintained. To demonstrate the proposed method, an amplitude-based concomitant motion comparison is performed on two widely utilized lower-mobility parallel mechanisms, 3RPS and 3PRS. The result has shown that for the selected mechanisms, concomitant motion is identical regardless of their difference in joint arrangements in each limbs.

  • Publication . Part of book or chapter of book . 2014
    English
    Authors: 
    Athanase Benetos; Abraham Aviv; Patrick Lacolley; Michel E. Safar; Véronique Regnault;
    Publisher: HAL CCSD
    Country: France

    Increases in arterial stiffness and pulse pressure are typical features of the arterial stiffness during aging and are associated with increased risk of cardiovascular complications. Cellular and molecular determinants of arterial stiffness have not been completely elucidated. Clinically, the carotid-femoral pulse wave velocity (PWV) is the gold standard parameter of arterial stiffness. A recent genome-wide scan of the Framingham Heart Study population has shown that arterial stiffness and mean and pulsatile components of blood pressure are heritable and map to separate the genetic loci in humans, suggesting that distinct genes may modulate these two phenotypes. This chapter details the recent knowledge on the influence of genetic determinants and telomere length on the development of age-related phenotypes. Recent genetic studies have revealed specific genes contributing to arterial stiffening. Available data on genome-wide association (GWA) have been initiated on PWV and have identified common genetic variation in specific loci or single-nucleotide polymorphisms (SNP) significantly associated with PWV. Telomere length at birth is strongly determined genetically and is the main determinant of leukocytes’ telomere length (LTL) later in life. Short LTL is associated with increased risk of stiffness and atherosclerosis of the carotid artery, atherosclerotic heart disease, and diminished survival in the elderly.

  • Open Access English
    Authors: 
    Taiwo Oyedare; Ashraf Al Sharah; Sachin Shetty;
    Publisher: HAL CCSD
    Country: France

    Part 6: Network Modeling; International audience; Mobile Adhoc Networks (MANET) are susceptible to jamming attacks which can inhibit data transmissions. There has been considerable work done in the detection of external jamming attacks. However, detection of insider jamming attack in MANET has not received enough attention. The presence of an insider node that has constantly monitored the network and is privy to the network secrets can acquire sufficient information to cause irreparable damage. In this paper we propose a framework for a novel reputation-based coalition game between multiple players in a MANET to prevent internal attacks caused by an erstwhile legitimate node. A grand coalition is formed which will make a strategic security defense decision by depending on the stored transmission rate and reputation for each individual node in the coalition. Our results show that the simulation of the reputation-based coalition game would help improve the network’s defense strategy while also reducing false positives that results from the incorrect classification of unfortunate legitimate nodes as insider jammers.

  • Publication . Other literature type . Part of book or chapter of book . 2019
    Closed Access English
    Authors: 
    Romain Quentin; Oluwole Awosika; Leonardo G. Cohen;
    Publisher: HAL CCSD

    Abstract The frontal lobe plays a crucial role in human motor behavior. It is one of the last areas of the brain to mature, especially the prefrontal regions. After a brief historical perspective on the perceived dichotomy between the view of the brain as a static organ and that of a plastic, constantly changing structure, we discuss the stability/plasticity dilemma including examples of documented cortical reorganization taking place at multiple spatial and temporal scales. We pose that while plasticity is needed for motor learning, stability of the system is necessary for storage and maintenance of memorized skills. We discuss how this plasticity/stability dilemma is resolved along the life span and after a brain injury. We then examine the main challenges that clinicians have to overcome to promote recovery of function in patients with brain lesions, including attempts to use neurostimulation techniques as adjuvant to training-based customary neurorehabilitation.

  • Publication . Part of book or chapter of book . Other literature type . Conference object . 2013
    Open Access English
    Authors: 
    Paolo W. Pecorario;
    Publisher: HAL CCSD

    Part IV: ICT and Emerging Technologies; International audience; The purpose of this paper is to describe how to implement the utility theory to a supply chain problem. In this problem, two different modes of freight transportation are compared to improve life cycle performance of a mass product: trucks and trains. First, the problem is described, the criteria and attributes are introduced and the dataset for this problem is defined. Then, a description of the utility theory model is conducted, explaining the choice of the multiplicative model instead of the additive one. After that, the utility functions for each attribute are elicited, and a trade-off analysis is conducted in order to define indifference points and to calculate the scaling factors. Then, the aggregation function is formulated for this problem, the alternatives ranked, and the best mode of transportation elicited.

  • Publication . Part of book or chapter of book . 2019
    Closed Access English
    Authors: 
    Dan E. Webster; Sandrine Roulland; James D. Phelan;
    Publisher: HAL CCSD
    Country: France
    Project: EC | LYMPHOSIGN (661066)

    Genome-wide screens are a powerful technique to dissect the complex network of genes regulating diverse cellular phenotypes. The recent adaptation of the CRISPR-Cas9 system for genome engineering has revolutionized functional genomic screening. Here, we present protocols used to introduce Cas9 into human lymphoma cell lines, produce high-titer lentivirus of a genome-wide sgRNA library, transduce and culture cells during the screen, isolate genomic DNA, and prepare a custom library for next-generation sequencing. These protocols were tailored for loss-of-function CRISPR screens in human lymphoma cell lines but are highly amenable for other experimental purposes.

  • Publication . Conference object . 2016
    Closed Access English
    Authors: 
    Dianne Foreback; Mikhail Nesterenko; Sébastien Tixeuil;
    Publisher: HAL CCSD
    Country: France

    International audience; We study unlimited infinite churn in peer-to-peer overlay networks. Under this churn, arbitrary many peers may concurrently request to join or leave the overlay network; moreover these requests may never stop coming. We prove that unlimited adversarial churn, where processes may just exit the overlay network, is unsolvable. We focus on cooperative churn where exiting processes participate in the churn handling algorithm. We define the problem of unlimited infinite churn in this setting. We distinguish the fair version of the problem, where each request is eventually satisfied, from the unfair version that just guarantees progress. We focus on local solutions to the problem, and prove that a local solution to the Fair Infinite Unlimited Churn is impossible. We then present our algorithm UIUC that solves the Unfair Infinite Unlimited Churn Problem for a linearized peer-to-peer overlay network. We extend this solution to skip lists and skip graphs.

  • Publication . Other literature type . Part of book or chapter of book . Conference object . 2019
    Closed Access
    Authors: 
    Yan Li; Manoj A. Thomas;
    Publisher: Springer International Publishing

    Part 1: Pushing the Boundaries - New Research Methods, Theory and Philosophy in ICT4D; International audience; A compendium of impact assessment (IA) frameworks are available to understand the impact of ICT4D initiatives in Low Income Countries. However, existing frameworks do not adequately address the unique challenges of IA for ICT4D, especially the multi-level and time variant characteristics of the IA. To address these challenges, we propose the use of Theory of change (ToC) as a generic framework for IA of ICT4D projects. Based on the seminal work by Weiss [8], we argue that ToC can be viewed both as a methodology and a deep critical reflection process. We demonstrate the ToC approach for IA using a case study of an ICT4D project for LICs.

search
Include:
3,105 Research products, page 1 of 311
  • Publication . Part of book or chapter of book . Conference object . Other literature type . Article . 2016
    Open Access English
    Authors: 
    Florent Berthaut; Luke Dahl;
    Publisher: HAL CCSD
    Country: France
    Project: EC | IXMI (330770)

    International audience; Orchestras of Digital Musical Instruments (DMIs) enable new musical collaboration possibilities, extending those of acoustic and electric orchestras. However the creation and development of these orchestras remain constrained. In fact, each new musical collaboration system or orchestra piece relies on a fixed number of musicians, a fixed set of instruments (often only one), and a fixed subset of possible modes of collaboration. In this paper, we describe a unified framework that enables the design of Digital Orchestras with potentially different DMIs and an expand-able set of collaboration modes. It relies on research done on analysis and classification of traditional and digital orchestras, on research in Collaborative Virtual Environments, and on interviews of musicians and composers. The BOEUF framework consists of a classification of modes of collaboration and a set of components for modelling digital orchestras. Integrating this framework into DMIs will enable advanced musical collaboration modes to be used in any digital orchestra, including spontaneous jam sessions.

  • Publication . Part of book or chapter of book . 2018
    Closed Access
    Authors: 
    Thierry Billard; François Liger; Mathieu Verdurand;
    Publisher: Elsevier
    Country: France

    Abstract The serotonergic system plays a key modulatory role in the brain. This system is critical in many drug developments for brain disorders via interactions with the 14 subtypes of 5-HT receptors or through reuptake blockade. Positron emission tomography (PET) is an efficient tool for in vivo studies of physiological and pathological processes. Because of its pertinent radiochemical properties, fluorine-18 is one of the most used radioisotopes in PET imaging. This chapter will propose an overview of the 18F-radioligands targeting serotonin receptors, which have been developed over the last few years. Both radiosyntheses and pharmacological properties of these radiotracers will be described, with a specific emphasis on their potential medical applications.

  • Publication . Article . Part of book or chapter of book . 2020
    Open Access English
    Authors: 
    Hassen Nigatu; Yimesker Yihun;
    Publisher: HAL CCSD
    Country: France

    International audience; This study presents an algebraic method to detect, count, and identify concomitant motions of parallel robots at the velocity level. The pose and orientation of moving platform of parallel manipulators (PMs) with f-DOF could be commonly described by f possible motion variables on the instantaneous motion space (IMS) and (6 − f) restriction motion variables on the instantaneous restriction space (IRS). However, in some situations, PMs moving platform may accompanied by a concomitant (parasitic) motions along the direction of restriction space. Therefore, the commonly understood one-to-one correspondence between joint space and task space mobility of non-redundant PMs would be compromised. This phenomenon occurred due to the fact that the alignment of screws can change the reciprocal screws while the given screw systems are still maintained. To demonstrate the proposed method, an amplitude-based concomitant motion comparison is performed on two widely utilized lower-mobility parallel mechanisms, 3RPS and 3PRS. The result has shown that for the selected mechanisms, concomitant motion is identical regardless of their difference in joint arrangements in each limbs.

  • Publication . Part of book or chapter of book . 2014
    English
    Authors: 
    Athanase Benetos; Abraham Aviv; Patrick Lacolley; Michel E. Safar; Véronique Regnault;
    Publisher: HAL CCSD
    Country: France

    Increases in arterial stiffness and pulse pressure are typical features of the arterial stiffness during aging and are associated with increased risk of cardiovascular complications. Cellular and molecular determinants of arterial stiffness have not been completely elucidated. Clinically, the carotid-femoral pulse wave velocity (PWV) is the gold standard parameter of arterial stiffness. A recent genome-wide scan of the Framingham Heart Study population has shown that arterial stiffness and mean and pulsatile components of blood pressure are heritable and map to separate the genetic loci in humans, suggesting that distinct genes may modulate these two phenotypes. This chapter details the recent knowledge on the influence of genetic determinants and telomere length on the development of age-related phenotypes. Recent genetic studies have revealed specific genes contributing to arterial stiffening. Available data on genome-wide association (GWA) have been initiated on PWV and have identified common genetic variation in specific loci or single-nucleotide polymorphisms (SNP) significantly associated with PWV. Telomere length at birth is strongly determined genetically and is the main determinant of leukocytes’ telomere length (LTL) later in life. Short LTL is associated with increased risk of stiffness and atherosclerosis of the carotid artery, atherosclerotic heart disease, and diminished survival in the elderly.

  • Open Access English
    Authors: 
    Taiwo Oyedare; Ashraf Al Sharah; Sachin Shetty;
    Publisher: HAL CCSD
    Country: France

    Part 6: Network Modeling; International audience; Mobile Adhoc Networks (MANET) are susceptible to jamming attacks which can inhibit data transmissions. There has been considerable work done in the detection of external jamming attacks. However, detection of insider jamming attack in MANET has not received enough attention. The presence of an insider node that has constantly monitored the network and is privy to the network secrets can acquire sufficient information to cause irreparable damage. In this paper we propose a framework for a novel reputation-based coalition game between multiple players in a MANET to prevent internal attacks caused by an erstwhile legitimate node. A grand coalition is formed which will make a strategic security defense decision by depending on the stored transmission rate and reputation for each individual node in the coalition. Our results show that the simulation of the reputation-based coalition game would help improve the network’s defense strategy while also reducing false positives that results from the incorrect classification of unfortunate legitimate nodes as insider jammers.

  • Publication . Other literature type . Part of book or chapter of book . 2019
    Closed Access English
    Authors: 
    Romain Quentin; Oluwole Awosika; Leonardo G. Cohen;
    Publisher: HAL CCSD

    Abstract The frontal lobe plays a crucial role in human motor behavior. It is one of the last areas of the brain to mature, especially the prefrontal regions. After a brief historical perspective on the perceived dichotomy between the view of the brain as a static organ and that of a plastic, constantly changing structure, we discuss the stability/plasticity dilemma including examples of documented cortical reorganization taking place at multiple spatial and temporal scales. We pose that while plasticity is needed for motor learning, stability of the system is necessary for storage and maintenance of memorized skills. We discuss how this plasticity/stability dilemma is resolved along the life span and after a brain injury. We then examine the main challenges that clinicians have to overcome to promote recovery of function in patients with brain lesions, including attempts to use neurostimulation techniques as adjuvant to training-based customary neurorehabilitation.

  • Publication . Part of book or chapter of book . Other literature type . Conference object . 2013
    Open Access English
    Authors: 
    Paolo W. Pecorario;
    Publisher: HAL CCSD

    Part IV: ICT and Emerging Technologies; International audience; The purpose of this paper is to describe how to implement the utility theory to a supply chain problem. In this problem, two different modes of freight transportation are compared to improve life cycle performance of a mass product: trucks and trains. First, the problem is described, the criteria and attributes are introduced and the dataset for this problem is defined. Then, a description of the utility theory model is conducted, explaining the choice of the multiplicative model instead of the additive one. After that, the utility functions for each attribute are elicited, and a trade-off analysis is conducted in order to define indifference points and to calculate the scaling factors. Then, the aggregation function is formulated for this problem, the alternatives ranked, and the best mode of transportation elicited.

  • Publication . Part of book or chapter of book . 2019
    Closed Access English
    Authors: 
    Dan E. Webster; Sandrine Roulland; James D. Phelan;
    Publisher: HAL CCSD
    Country: France
    Project: EC | LYMPHOSIGN (661066)

    Genome-wide screens are a powerful technique to dissect the complex network of genes regulating diverse cellular phenotypes. The recent adaptation of the CRISPR-Cas9 system for genome engineering has revolutionized functional genomic screening. Here, we present protocols used to introduce Cas9 into human lymphoma cell lines, produce high-titer lentivirus of a genome-wide sgRNA library, transduce and culture cells during the screen, isolate genomic DNA, and prepare a custom library for next-generation sequencing. These protocols were tailored for loss-of-function CRISPR screens in human lymphoma cell lines but are highly amenable for other experimental purposes.

  • Publication . Conference object . 2016
    Closed Access English
    Authors: 
    Dianne Foreback; Mikhail Nesterenko; Sébastien Tixeuil;
    Publisher: HAL CCSD
    Country: France

    International audience; We study unlimited infinite churn in peer-to-peer overlay networks. Under this churn, arbitrary many peers may concurrently request to join or leave the overlay network; moreover these requests may never stop coming. We prove that unlimited adversarial churn, where processes may just exit the overlay network, is unsolvable. We focus on cooperative churn where exiting processes participate in the churn handling algorithm. We define the problem of unlimited infinite churn in this setting. We distinguish the fair version of the problem, where each request is eventually satisfied, from the unfair version that just guarantees progress. We focus on local solutions to the problem, and prove that a local solution to the Fair Infinite Unlimited Churn is impossible. We then present our algorithm UIUC that solves the Unfair Infinite Unlimited Churn Problem for a linearized peer-to-peer overlay network. We extend this solution to skip lists and skip graphs.

  • Publication . Other literature type . Part of book or chapter of book . Conference object . 2019
    Closed Access
    Authors: 
    Yan Li; Manoj A. Thomas;
    Publisher: Springer International Publishing

    Part 1: Pushing the Boundaries - New Research Methods, Theory and Philosophy in ICT4D; International audience; A compendium of impact assessment (IA) frameworks are available to understand the impact of ICT4D initiatives in Low Income Countries. However, existing frameworks do not adequately address the unique challenges of IA for ICT4D, especially the multi-level and time variant characteristics of the IA. To address these challenges, we propose the use of Theory of change (ToC) as a generic framework for IA of ICT4D projects. Based on the seminal work by Weiss [8], we argue that ToC can be viewed both as a methodology and a deep critical reflection process. We demonstrate the ToC approach for IA using a case study of an ICT4D project for LICs.

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