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77,975 research outcomes, page 1 of 7,798
  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Karoline Kuchenbaecker; Kyriaki Michailidou; Gustavo Mendoza-Fandino; Silje Nord; Janna Lilyquist; Curtis Olswold; Simona Agata; Habibul Ahsan; Kristiina Aittomäki; Christine B. Ambrosone; ...
    Publisher: Nature Publishing Group
    Project: NIH | Discovery Expansion and R... (5U19CA148065-04), NIH | A genome-wide association... (5R01CA128978-02), EC | COGS (223175), NIH | Elucidating Loci Involved... (5U19CA148537-02), NWO | Secure and gentle grip of... (2300183393), WT , NIH | Follow-up of Ovarian Canc... (3U19CA148112-04S1), CIHR

    B.C.A.C. was funded through a European Community Seventh Framework Programme under grant agreement no 223175 (HEALTH-F2-2009-223175; COGS); Cancer Research UK (C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692); the Nationa...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Roseanne Briffitt; Iain J. Day;
    Persistent Identifiers
    Publisher: American Chemical Society

    The self-association of small aromatic systems driven by π-π stacking and hydrophobic interactions is well known. Understanding the nature of these interactions is important if they are to be used to control association. Here, we present results of an NMR study into the...

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  • publication . Article . 2017
    Open Access English
    Authors:
    Jethro Johnson; Monica N Opiyo; Marian Thomson; Karim Gharbi; Jonathan R. Seckl; Andreas Heger; Karen E. Chapman;
    Project: WT | 11beta hydroxysteroid deh... (083184), UKRI | Future-Proofing the Susta... (MR/K001744/1)

    The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) interconverts active glucocorticoids and their intrinsically inert 11-keto forms. The type 1 isozyme, 11β-HSD1, predominantly reactivates glucocorticoids in vivo and can also metabolise bile acids. 11β-HSD1-deficient...

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  • publication . Contribution for newspaper or weekly magazine . 2016
    Open Access English
    Authors:
    Console, Marco;

    In the context of Ontology Based Data Access (OBDA), consistency of data ensures that the data sources are coherent with the rules of the domain of interest represented by the ontology.However, even when consistency holds, the data underlying an OBDA system canstill be ...

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  • publication . Book . 2010
    Open Access English
    Authors:
    Demirag, Istemi; Khadaroo, Iqbal; Stapleton, Pamela; Stevenson, Caral;
    Publisher: Institute of Chartered Accountants of Scotland

    Public private partnerships (PPP) are used extensively in the provision of public services but who bears the risk in such schemes. This new research report takes a new and different perspective on PPP schemes by examining the perceptions of risks from the perspective of...

  • publication . Article . 2006
    Open Access English
    Authors:
    Sebastian Carotta; Melissa L. Holmes; Clare Pridans; Stephen L. Nutt;

    The transcription factor Pax5 is required for many aspects of B-lymphopoiesis including lineage commitment, immunoglobulin rearrangement, pre-BCR signalling and mature B cell survival. Pax5 regulates B cell lineage commitment by concurrently activating cell specific gen...

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  • publication . Article . 2020
    Open Access
    Authors:
    Sérgio A. Carvalho; José Pinto-Gouveia; David Gillanders; Paula Castilho;
    Publisher: Wiley

    BACKGROUND Research suggests that the way others react to a pain flare-up impacts on psychological and pain-related symptoms in chronic pain (CP). Experiencing validation from others is associated with less negative emotions and better functioning. Contrarily, experienc...

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  • publication . Other literature type . Article . 2006
    Open Access English
    Authors:
    Farhad Forouhar; J. L. Ross Anderson; Christopher G. Mowat; Sergey M. Vorobiev; A. Hussain; Mariam Abashidze; Chiara Bruckmann; Sarah J. Thackray; Jayaraman Seetharaman; Todd Tucker; ...
    Publisher: National Academy of Sciences

    Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) constitute an important, yet relatively poorly understood, family of heme-containing enzymes. Here, we report extensive structural and biochemical studies of the Xanthomonas campestris TDO and a rela...

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  • publication . Preprint . Conference object . Contribution for newspaper or weekly magazine . 2015
    Open Access English
    Authors:
    Luca Del Pero; Susanna Ricco; Rahul Sukthankar; Vittorio Ferrari;

    We propose an unsupervised approach for discovering characteristic motion patterns in videos of highly articulated objects performing natural, unscripted behaviors, such as tigers in the wild. We discover consistent patterns in a bottom-up manner by analyzing the relati...

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  • Picture this. You have a research question of international importance. Against the odds, you have secured non-commercial funding for a well-designed multicentre project that will answer the question. Naturally, you must obtain research ethics committee (REC) approval. ...

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77,975 research outcomes, page 1 of 7,798