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  • Publication . Part of book or chapter of book . Conference object . Other literature type . Article . 2016
    Open Access English
    Authors: 
    Florent Berthaut; Luke Dahl;
    Publisher: HAL CCSD
    Country: France
    Project: EC | IXMI (330770)

    International audience; Orchestras of Digital Musical Instruments (DMIs) enable new musical collaboration possibilities, extending those of acoustic and electric orchestras. However the creation and development of these orchestras remain constrained. In fact, each new musical collaboration system or orchestra piece relies on a fixed number of musicians, a fixed set of instruments (often only one), and a fixed subset of possible modes of collaboration. In this paper, we describe a unified framework that enables the design of Digital Orchestras with potentially different DMIs and an expand-able set of collaboration modes. It relies on research done on analysis and classification of traditional and digital orchestras, on research in Collaborative Virtual Environments, and on interviews of musicians and composers. The BOEUF framework consists of a classification of modes of collaboration and a set of components for modelling digital orchestras. Integrating this framework into DMIs will enable advanced musical collaboration modes to be used in any digital orchestra, including spontaneous jam sessions.

  • Open Access English
    Authors: 
    Taiwo Oyedare; Ashraf Al Sharah; Sachin Shetty;
    Publisher: HAL CCSD
    Country: France

    Part 6: Network Modeling; International audience; Mobile Adhoc Networks (MANET) are susceptible to jamming attacks which can inhibit data transmissions. There has been considerable work done in the detection of external jamming attacks. However, detection of insider jamming attack in MANET has not received enough attention. The presence of an insider node that has constantly monitored the network and is privy to the network secrets can acquire sufficient information to cause irreparable damage. In this paper we propose a framework for a novel reputation-based coalition game between multiple players in a MANET to prevent internal attacks caused by an erstwhile legitimate node. A grand coalition is formed which will make a strategic security defense decision by depending on the stored transmission rate and reputation for each individual node in the coalition. Our results show that the simulation of the reputation-based coalition game would help improve the network’s defense strategy while also reducing false positives that results from the incorrect classification of unfortunate legitimate nodes as insider jammers.

  • Publication . Part of book or chapter of book . 2019
    Closed Access
    Authors: 
    Dan E. Webster; Sandrine Roulland; James D. Phelan;
    Country: France
    Project: EC | LYMPHOSIGN (661066)

    Genome-wide screens are a powerful technique to dissect the complex network of genes regulating diverse cellular phenotypes. The recent adaptation of the CRISPR-Cas9 system for genome engineering has revolutionized functional genomic screening. Here, we present protocols used to introduce Cas9 into human lymphoma cell lines, produce high-titer lentivirus of a genome-wide sgRNA library, transduce and culture cells during the screen, isolate genomic DNA, and prepare a custom library for next-generation sequencing. These protocols were tailored for loss-of-function CRISPR screens in human lymphoma cell lines but are highly amenable for other experimental purposes.

  • Open Access English
    Authors: 
    Gregory R. Brady; Peter Petrone; Iva Laginja; Keira Brooks; Manxuan Zhang; Mamadou N'Diaye; Christopher Moriarty; John G. Hagopian; Rémi Soummer;
    Publisher: Society of Photo-Optical Instrumentation Engineers (SPIE)
    Countries: France, United States

    We discuss the use of parametric phase-diverse phase retrieval to characterize and optimize the transmitted wavefront of a high-contrast apodized pupil coronagraph with and without an apodizer. We apply our method to correct the transmitted wavefront of the HiCAT (High contrast imager for Complex Aperture Telescopes) coronagraphic testbed. This correction requires a series of calibration steps, which we describe. The correction improves the system wavefront from 16 nm RMS to 3.0 nm RMS for the case where a uniform circular aperture is in place. We further measure the wavefront with the apodizer in place to be 11.7 nm RMS. Improvement to the apodized pupil phase retrieval process is necessary before a correction based on this measurement can be applied.

  • Publication . Part of book or chapter of book . 2018
    Closed Access English
    Authors: 
    Thierry Billard; François Liger; Mathieu Verdurand;
    Publisher: HAL CCSD
    Country: France

    Abstract The serotonergic system plays a key modulatory role in the brain. This system is critical in many drug developments for brain disorders via interactions with the 14 subtypes of 5-HT receptors or through reuptake blockade. Positron emission tomography (PET) is an efficient tool for in vivo studies of physiological and pathological processes. Because of its pertinent radiochemical properties, fluorine-18 is one of the most used radioisotopes in PET imaging. This chapter will propose an overview of the 18F-radioligands targeting serotonin receptors, which have been developed over the last few years. Both radiosyntheses and pharmacological properties of these radiotracers will be described, with a specific emphasis on their potential medical applications.

  • English
    Authors: 
    Bouchez, Daniel;
    Publisher: HAL CCSD
    Country: France

    [p. 445] THE SUBJECT OF this paper is a collection of essays composed, in the words of the title "as the brush goes," by Sŏp'o, that is, by Kim Manjung (1637-1692). He is well known, as the author of a masterpiece of Korean fiction, the novel Nine Cloud Dream (Kuunmong). He is also credited with another novel, less famous but not less interesting, The Record of a Southern Journey (Namjŏng ki), which is especially well documented and on which I have already published several articles.

  • Publication . Part of book or chapter of book . 2014
    English
    Authors: 
    Athanase Benetos; Abraham Aviv; Patrick Lacolley; Michel E. Safar; Véronique Regnault;
    Publisher: HAL CCSD
    Country: France

    Increases in arterial stiffness and pulse pressure are typical features of the arterial stiffness during aging and are associated with increased risk of cardiovascular complications. Cellular and molecular determinants of arterial stiffness have not been completely elucidated. Clinically, the carotid-femoral pulse wave velocity (PWV) is the gold standard parameter of arterial stiffness. A recent genome-wide scan of the Framingham Heart Study population has shown that arterial stiffness and mean and pulsatile components of blood pressure are heritable and map to separate the genetic loci in humans, suggesting that distinct genes may modulate these two phenotypes. This chapter details the recent knowledge on the influence of genetic determinants and telomere length on the development of age-related phenotypes. Recent genetic studies have revealed specific genes contributing to arterial stiffening. Available data on genome-wide association (GWA) have been initiated on PWV and have identified common genetic variation in specific loci or single-nucleotide polymorphisms (SNP) significantly associated with PWV. Telomere length at birth is strongly determined genetically and is the main determinant of leukocytes’ telomere length (LTL) later in life. Short LTL is associated with increased risk of stiffness and atherosclerosis of the carotid artery, atherosclerotic heart disease, and diminished survival in the elderly.

  • Publication . Part of book or chapter of book . 2012
    Open Access English
    Authors: 
    Wakelam, V.; Cuppen, H.M.; Herbst, E.; Smith, I.W.M.; Cockell, C.S.; Leach, S.;
    Publisher: Springer-Verlag GmbH
    Countries: Netherlands, France, France
    Project: EC | KISMOL (259510)

    2013, IX, 349 p. 79 illus., 55 in color; International audience; We discuss models that astrochemists have developed to study the chemical composition of the interstellar medium. These models aim at computing the evolution of the chemical composition of a mixture of gas and dust under astrophysical conditions. These conditions, as well as the geometry and the physical dynamics, have to be adapted to the objects being studied because different classes of objects have very different characteristics (temperatures, densities, UV radiation fields, geometry, history etc); e.g., proto-planetary disks do not have the same characteristics as proto-stellar envelopes. Chemical models are being improved continually thanks to comparisons with observations but also thanks to laboratory and theoretical work in which the individual processes are studied.

  • Publication . Article . Part of book or chapter of book . 2020
    Open Access English
    Authors: 
    Hassen Nigatu; Yimesker Yihun;
    Publisher: HAL CCSD
    Country: France

    International audience; This study presents an algebraic method to detect, count, and identify concomitant motions of parallel robots at the velocity level. The pose and orientation of moving platform of parallel manipulators (PMs) with f-DOF could be commonly described by f possible motion variables on the instantaneous motion space (IMS) and (6 − f) restriction motion variables on the instantaneous restriction space (IRS). However, in some situations, PMs moving platform may accompanied by a concomitant (parasitic) motions along the direction of restriction space. Therefore, the commonly understood one-to-one correspondence between joint space and task space mobility of non-redundant PMs would be compromised. This phenomenon occurred due to the fact that the alignment of screws can change the reciprocal screws while the given screw systems are still maintained. To demonstrate the proposed method, an amplitude-based concomitant motion comparison is performed on two widely utilized lower-mobility parallel mechanisms, 3RPS and 3PRS. The result has shown that for the selected mechanisms, concomitant motion is identical regardless of their difference in joint arrangements in each limbs.

  • Open Access English
    Authors: 
    Jacqueline Gottlieb; Manuel Lopes; Pierre-Yves Oudeyer;
    Publisher: HAL CCSD
    Country: France

    International audience; Based on a synthesis of findings from psychology, neuroscience, and machine learning, we propose a unified theory of curiosity as a form of motivated cognition. Curiosity, we propose, is comprised of a family of mechanisms that range in complexity from simple heuristics based on novelty, salience, or surprise, to drives based on reward and uncertainty reduction and finally, to self-directed metacognitive processes. These mechanisms, we propose, have evolved to allow agents to discover useful regularities in the world ! steering them toward niches of maximal learning progress and away from both random and highly familiar tasks. We emphasize that curiosity arises organically in conjunction with cogni- tion and motivation, being generated by cognitive processes and in turn, motivating them. We hope that this view will spur the systematic study of curiosity as an integral aspect of cognition and decision making during development and adulthood.

search
Include:
3,823 Research products, page 1 of 383
  • Publication . Part of book or chapter of book . Conference object . Other literature type . Article . 2016
    Open Access English
    Authors: 
    Florent Berthaut; Luke Dahl;
    Publisher: HAL CCSD
    Country: France
    Project: EC | IXMI (330770)

    International audience; Orchestras of Digital Musical Instruments (DMIs) enable new musical collaboration possibilities, extending those of acoustic and electric orchestras. However the creation and development of these orchestras remain constrained. In fact, each new musical collaboration system or orchestra piece relies on a fixed number of musicians, a fixed set of instruments (often only one), and a fixed subset of possible modes of collaboration. In this paper, we describe a unified framework that enables the design of Digital Orchestras with potentially different DMIs and an expand-able set of collaboration modes. It relies on research done on analysis and classification of traditional and digital orchestras, on research in Collaborative Virtual Environments, and on interviews of musicians and composers. The BOEUF framework consists of a classification of modes of collaboration and a set of components for modelling digital orchestras. Integrating this framework into DMIs will enable advanced musical collaboration modes to be used in any digital orchestra, including spontaneous jam sessions.

  • Open Access English
    Authors: 
    Taiwo Oyedare; Ashraf Al Sharah; Sachin Shetty;
    Publisher: HAL CCSD
    Country: France

    Part 6: Network Modeling; International audience; Mobile Adhoc Networks (MANET) are susceptible to jamming attacks which can inhibit data transmissions. There has been considerable work done in the detection of external jamming attacks. However, detection of insider jamming attack in MANET has not received enough attention. The presence of an insider node that has constantly monitored the network and is privy to the network secrets can acquire sufficient information to cause irreparable damage. In this paper we propose a framework for a novel reputation-based coalition game between multiple players in a MANET to prevent internal attacks caused by an erstwhile legitimate node. A grand coalition is formed which will make a strategic security defense decision by depending on the stored transmission rate and reputation for each individual node in the coalition. Our results show that the simulation of the reputation-based coalition game would help improve the network’s defense strategy while also reducing false positives that results from the incorrect classification of unfortunate legitimate nodes as insider jammers.

  • Publication . Part of book or chapter of book . 2019
    Closed Access
    Authors: 
    Dan E. Webster; Sandrine Roulland; James D. Phelan;
    Country: France
    Project: EC | LYMPHOSIGN (661066)

    Genome-wide screens are a powerful technique to dissect the complex network of genes regulating diverse cellular phenotypes. The recent adaptation of the CRISPR-Cas9 system for genome engineering has revolutionized functional genomic screening. Here, we present protocols used to introduce Cas9 into human lymphoma cell lines, produce high-titer lentivirus of a genome-wide sgRNA library, transduce and culture cells during the screen, isolate genomic DNA, and prepare a custom library for next-generation sequencing. These protocols were tailored for loss-of-function CRISPR screens in human lymphoma cell lines but are highly amenable for other experimental purposes.

  • Open Access English
    Authors: 
    Gregory R. Brady; Peter Petrone; Iva Laginja; Keira Brooks; Manxuan Zhang; Mamadou N'Diaye; Christopher Moriarty; John G. Hagopian; Rémi Soummer;
    Publisher: Society of Photo-Optical Instrumentation Engineers (SPIE)
    Countries: France, United States

    We discuss the use of parametric phase-diverse phase retrieval to characterize and optimize the transmitted wavefront of a high-contrast apodized pupil coronagraph with and without an apodizer. We apply our method to correct the transmitted wavefront of the HiCAT (High contrast imager for Complex Aperture Telescopes) coronagraphic testbed. This correction requires a series of calibration steps, which we describe. The correction improves the system wavefront from 16 nm RMS to 3.0 nm RMS for the case where a uniform circular aperture is in place. We further measure the wavefront with the apodizer in place to be 11.7 nm RMS. Improvement to the apodized pupil phase retrieval process is necessary before a correction based on this measurement can be applied.

  • Publication . Part of book or chapter of book . 2018
    Closed Access English
    Authors: 
    Thierry Billard; François Liger; Mathieu Verdurand;
    Publisher: HAL CCSD
    Country: France

    Abstract The serotonergic system plays a key modulatory role in the brain. This system is critical in many drug developments for brain disorders via interactions with the 14 subtypes of 5-HT receptors or through reuptake blockade. Positron emission tomography (PET) is an efficient tool for in vivo studies of physiological and pathological processes. Because of its pertinent radiochemical properties, fluorine-18 is one of the most used radioisotopes in PET imaging. This chapter will propose an overview of the 18F-radioligands targeting serotonin receptors, which have been developed over the last few years. Both radiosyntheses and pharmacological properties of these radiotracers will be described, with a specific emphasis on their potential medical applications.

  • English
    Authors: 
    Bouchez, Daniel;
    Publisher: HAL CCSD
    Country: France

    [p. 445] THE SUBJECT OF this paper is a collection of essays composed, in the words of the title "as the brush goes," by Sŏp'o, that is, by Kim Manjung (1637-1692). He is well known, as the author of a masterpiece of Korean fiction, the novel Nine Cloud Dream (Kuunmong). He is also credited with another novel, less famous but not less interesting, The Record of a Southern Journey (Namjŏng ki), which is especially well documented and on which I have already published several articles.

  • Publication . Part of book or chapter of book . 2014
    English
    Authors: 
    Athanase Benetos; Abraham Aviv; Patrick Lacolley; Michel E. Safar; Véronique Regnault;
    Publisher: HAL CCSD
    Country: France

    Increases in arterial stiffness and pulse pressure are typical features of the arterial stiffness during aging and are associated with increased risk of cardiovascular complications. Cellular and molecular determinants of arterial stiffness have not been completely elucidated. Clinically, the carotid-femoral pulse wave velocity (PWV) is the gold standard parameter of arterial stiffness. A recent genome-wide scan of the Framingham Heart Study population has shown that arterial stiffness and mean and pulsatile components of blood pressure are heritable and map to separate the genetic loci in humans, suggesting that distinct genes may modulate these two phenotypes. This chapter details the recent knowledge on the influence of genetic determinants and telomere length on the development of age-related phenotypes. Recent genetic studies have revealed specific genes contributing to arterial stiffening. Available data on genome-wide association (GWA) have been initiated on PWV and have identified common genetic variation in specific loci or single-nucleotide polymorphisms (SNP) significantly associated with PWV. Telomere length at birth is strongly determined genetically and is the main determinant of leukocytes’ telomere length (LTL) later in life. Short LTL is associated with increased risk of stiffness and atherosclerosis of the carotid artery, atherosclerotic heart disease, and diminished survival in the elderly.

  • Publication . Part of book or chapter of book . 2012
    Open Access English
    Authors: 
    Wakelam, V.; Cuppen, H.M.; Herbst, E.; Smith, I.W.M.; Cockell, C.S.; Leach, S.;
    Publisher: Springer-Verlag GmbH
    Countries: Netherlands, France, France
    Project: EC | KISMOL (259510)

    2013, IX, 349 p. 79 illus., 55 in color; International audience; We discuss models that astrochemists have developed to study the chemical composition of the interstellar medium. These models aim at computing the evolution of the chemical composition of a mixture of gas and dust under astrophysical conditions. These conditions, as well as the geometry and the physical dynamics, have to be adapted to the objects being studied because different classes of objects have very different characteristics (temperatures, densities, UV radiation fields, geometry, history etc); e.g., proto-planetary disks do not have the same characteristics as proto-stellar envelopes. Chemical models are being improved continually thanks to comparisons with observations but also thanks to laboratory and theoretical work in which the individual processes are studied.

  • Publication . Article . Part of book or chapter of book . 2020
    Open Access English
    Authors: 
    Hassen Nigatu; Yimesker Yihun;
    Publisher: HAL CCSD
    Country: France

    International audience; This study presents an algebraic method to detect, count, and identify concomitant motions of parallel robots at the velocity level. The pose and orientation of moving platform of parallel manipulators (PMs) with f-DOF could be commonly described by f possible motion variables on the instantaneous motion space (IMS) and (6 − f) restriction motion variables on the instantaneous restriction space (IRS). However, in some situations, PMs moving platform may accompanied by a concomitant (parasitic) motions along the direction of restriction space. Therefore, the commonly understood one-to-one correspondence between joint space and task space mobility of non-redundant PMs would be compromised. This phenomenon occurred due to the fact that the alignment of screws can change the reciprocal screws while the given screw systems are still maintained. To demonstrate the proposed method, an amplitude-based concomitant motion comparison is performed on two widely utilized lower-mobility parallel mechanisms, 3RPS and 3PRS. The result has shown that for the selected mechanisms, concomitant motion is identical regardless of their difference in joint arrangements in each limbs.

  • Open Access English
    Authors: 
    Jacqueline Gottlieb; Manuel Lopes; Pierre-Yves Oudeyer;
    Publisher: HAL CCSD
    Country: France

    International audience; Based on a synthesis of findings from psychology, neuroscience, and machine learning, we propose a unified theory of curiosity as a form of motivated cognition. Curiosity, we propose, is comprised of a family of mechanisms that range in complexity from simple heuristics based on novelty, salience, or surprise, to drives based on reward and uncertainty reduction and finally, to self-directed metacognitive processes. These mechanisms, we propose, have evolved to allow agents to discover useful regularities in the world ! steering them toward niches of maximal learning progress and away from both random and highly familiar tasks. We emphasize that curiosity arises organically in conjunction with cogni- tion and motivation, being generated by cognitive processes and in turn, motivating them. We hope that this view will spur the systematic study of curiosity as an integral aspect of cognition and decision making during development and adulthood.

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