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  • Open Access English
    Authors: 
    Tape, Christopher J.; Ling, Stephanie; Dimitriadi, Maria; McMahon, Kelly M.; Worboys, Jonathan D.; Leong, Hui Sun; Norrie, Ida C.; Miller, Crispin; Poulogiannis, George; Lauffenburger, Douglas A.; +1 more
    Publisher: Elsevier
    Countries: United States, United Kingdom
    Project: NIH | Regulatory Networks in Ca... (3U54CA112967-05S2), WT | Quantitative proteomic di... (098847), NIH | Engineered Antibody EGFR ... (5R01CA096504-05)

    Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS[superscript G12D]) also regulates tumor cell signaling via stromal cells. By combining cell-specific proteome labeling with multivariate ph...

  • Open Access English
    Authors: 
    David Doran; Marc Rodriguez-Garcia; Rebecca Turk-MacLeod; Geoffrey J. T. Cooper; Leroy Cronin;
    Publisher: Beilstein-Institut
    Country: United Kingdom
    Project: UKRI | Programmable Molecular Me... (EP/J015156/1), EC | SMART-POM (670467), EC | EVOBLISS (611640)

    We propose that a chemically agnostic approach to explore the origin of life, using an automated recursive platform based on droplet microfluidics, could be used to induce artificial chemical evolution by iterations of growth, speciation, selection, and propagation. To ...

  • Publication . Part of book or chapter of book . 2015
    Open Access English
    Authors: 
    Carole Elliott; Sarah Robinson;
    Publisher: Routledge
    Country: United Kingdom

    No abstract available.

  • Open Access English
    Authors: 
    Rupert Bauersachs; Olivia Wu; Jean-Baptiste Briere; Kevin Bowrin; K. Borkowska; Anna Jakubowska; Vanessa Taieb; Mondher Toumi; Maria Huelsebeck;
    Publisher: Hindawi
    Country: United Kingdom

    Aims. Acetylsalicylic acid (ASA) is widely used for the prevention of atherothrombotic events in patients with chronic coronary artery disease (CAD) and peripheral artery disease (PAD), but the risk of vascular events remains high. We aimed at identifying randomised con...

  • Open Access English
    Authors: 
    Geraghty, R.J.; Rahn, E.; Petermann, P.; Hsu, M.-J.; Rixon, F.J.; Knebel-Mörsdorf, D.;
    Publisher: Public Library of Science
    Country: United Kingdom

    Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s). Most studies into virus entry have used cultured fibroblasts but since keratinocytes represent the primary entr...

  • Open Access English
    Authors: 
    Meng, Lin; Porr, Bernd; Gollee, Henrik;
    Publisher: Yiqi Yibiao Xuebao Zazhishe
    Country: United Kingdom

    The work presents a review on the technological advancements of functional electrical stimulation (FES) neuroprostheses\ud to restore gait walking over the last decades. The aim of an FES intervention is to functionally restore and rehabilitate individuals with\ud motor...

  • Open Access English
    Authors: 
    Silveira, A.; Mcleod, O.; Strawbridge, R.J.; Gertow, K.; Sennblad, B.; Baldassarre, D.; Veglia, F.; Deleskog, A.; Persson, J.; Leander, K.; +15 more
    Countries: Italy, United Kingdom, Sweden, Netherlands
    Project: EC | SUMMIT (115006), AKA | Carotid Intima Media Thic... (110413)

    Objective Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma...

  • Publication . Other literature type . Research . Article . Preprint . 2014
    Open Access English
    Authors: 
    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; +191 more
    Publisher: American Physical Society
    Countries: United Kingdom, France, United Kingdom, Netherlands, Spain, Italy, Italy, Netherlands, Switzerland, Italy
    Project: SNSF | High Precision CP Violati... (200020_152784)

    We report on measurements of the mass and lifetime of the Xi_b^- baryon using about 1800 Xi_b^- decays reconstructed in a proton-proton collision data set corresponding to an integrated luminosity of 3.0 fb^{-1} collected by the LHCb experiment. The decays are reconstru...

  • Open Access English
    Authors: 
    Ron, D.; Adams, D.R.; Baillie, G.S.; Long, A.; O’Connor, R.; Kiely, P.A.;
    Publisher: BioMed Central
    Countries: United States, Ireland, United Kingdom
    Project: NIH | Orexin/Hypocretin Recepto... (7P50AA017072-07), NIH | BDNF and Alcohol Addictio... (1R01AA016848-01A1), UKRI | cAMP phosphodiesterase-4:... (MR/J007412/1)

    Abstract This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer,...

  • Open Access English
    Authors: 
    Eric Scott; Charlotte Bryant; Gordon Cook; Philip Naysmith;
    Publisher: University of Arizona
    Country: United Kingdom

    The issue of comparability of measurements (and thus bias, accuracy, and precision of measurement) from diverse laboratories is one which has been the focus of some attention both within the radiocarbon community and the wider user communities. As a result, the 14C comm...