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In this work the rainfall in Telangana has been calculated based on rainfall data between 1985 to 2016.The calculations have been performed using Time Series method and Fast Fourier Transform (FFT) method. The results of these two methods are averaged for better reliability. The rainfall data is also analyzed in the frequency domain to identify the causes which are significantly contribute to the rainfall.

Data set from the article Moons P, Luyckx K, Thomet C, Budts W, Enomoto J, Sluman MA, Lu CW, Jackson JL, Khairy P, Cook SC, Chidambarathanu S, Alday L, Eriksen K, Dellborg M, Berghammer M, Johansson B, Mackie AS, Menahem S, Caruana M, Veldtman G, Soufi A, Fernandes SM, White K, Callus E, Kutty S, Ombelet F, Apers S, Kovacs AH; APPROACH-IS Consortium and the International Society for Adult Congenital Heart Disease (ISACHD). Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries. Can J Cardiol. 2021 Feb;37(2):215-223. doi: 10.1016/j.cjca.2020.03.044. Epub 2020 Apr 6. PMID: 32739453. This is the abstract: Background: We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects. Methods: In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale, respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect. Results: Patients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%). Conclusions: Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes.

Social change can be accelerated by events that eliminate or incapacitate large numbers of people who are in the prime of their lives and who, therefore, can best enforce social norms. One such event was the double shock of the Spanish flu and the First World War. By disrupting established ways and by increasing openness to new ways, it accelerated changes that were already in progress but still running into resistance or inertia. This paper will focus on two of those changes: modern evangelism, which altered the church’s role in the community, and the sunshine movement, which had impacts on anything that involved exposure to the sun. Modern evangelism benefited from the double shock, as indicated by a sharp rise in circulation of evangelical magazines after 1918. There was now a greater willingness to experience one’s faith in other ways and through other means, such as the new medium of radio, door-to-door canvassing, newspaper advertising, mass mailing, correspondence courses, and comics for children. In time, these business-inspired methods would encourage a perception of religion as a product to be marketed, distributed, and consumed. Meanwhile, the Spanish flu increased public support for measures to create a cleaner life environment, particularly the use of sunlight to sterilize air-borne droplets ejected by coughing and left on surfaces. There thus arose a movement to promote exposure to the sun in all areas of life, notably architecture, urban planning, recreation, fashion, and even relations between the sexes. Everything was redesigned to promote sun exposure. Although the beginnings of modern evangelism and the sunshine movement predated 1918, both gained momentum over the next decade, when conditions were more conducive to social change. Despite their far-reaching consequences, neither was initially seen as a challenge to traditional values.

Cet ensemble de donnée contient les données issues des entrevues que nous avons réalisé avec des spécialistes retrouvés dans le groupe Facebook de machines à écrire.

In order to identify candidate protein binding partners of the transcription factor HEB, we generated conditional HEBAlt-HA transgenic mice. The transgene consisted of an HA-tagged HEBAlt coding region inserted downstream of a ROSA26-loxP-stop-loxP sequence to enable Cre recombinase activated expression of the transgene. Mice with two transgenic alleles without Cre are termed "TT" whereas those bred onto the Vav-Cre background are termed "TTV". Whole thymocytes were obtained from TT (n=2) or TTV (n=2) mice and subjected to immunoprecipitation using an anti-HA antibody and magnetic beads. Samples were trypsin-digested and analyzed by mass spectrometry on a Q Exactive HF-X Mass Spectrometer by the SPARC BioCentre facility (SickKids, Toronto). Scaffold (version Scaffold_4.8.9, Proteome Software Inc., Portland, OR) was used to validate MS/MS based peptide and protein identifications. Protein probabilities were assigned by the Protein Prophet algorithm81.

This is a presentation meant to orient researchers new to the NeuroHub Platform project about our goals and high-level vision for the project.

Data set from the article Bernardini A, Camporeale A, Pieroni M, Pieruzzi F, Figliozzi S, Lusardi P, Spada M, Mignani R, Burlina A, Carubbi F, Battaglia Y, Graziani F, Pica S, Tondi L, Chow K, Boveri S, Olivotto I, Lombardi M. Atrial Dysfunction Assessed by Cardiac Magnetic Resonance as an Early Marker of Fabry Cardiomyopathy. JACC Cardiovasc Imaging. 2020 Oct;13(10):2262-2264. doi: 10.1016/j.jcmg.2020.05.011. Epub 2020 Jun 17. PMID: 32563647. Brief introduction Anderson-Fabry disease (AFD) cardiomyopathy is characterized by glycosphingolipid (Gb3) storage in all cellular components, with consequent left ventricular hypertrophy (LVH). Gb3 accumulation also involves atrial myocytes (1), ultimately leading to left atrial (LA) enlargement and reduced atrial compliance. Cardiac magnetic resonance (CMR) plays an important role in the assessment of the severity of Fabry cardiomyopathy. CMR feature tracking (CMR-FT) specifically allows the assessment of myocardial strain from cine images

Huntington’s Disease (HD) is a hereditary neurodegenerative disease; the cause of which is due to a CAG repeat extension in the huntingtin (HTT) Gene. This extension is then translated into an elongation of exon 1 which is primarily composed of a disordered PolyQ repeat. Although the cause is known, the mechanism by which this extension affects the function of HTT, the protein produced by the HTT Gene, has yet to be fully understood. A part of this difficulty is our lack of understanding of the role of normal HTT in our cells. To further our understanding of the role of HTT, we at the SGC have set out to explore the HTT interactome, which will give us a better idea of what specific interactions are modulated in HD. Our first step on this journey was to conduct a literature review alongside a BioID experiment to come up with a list of putative huntingtin interaction partners. One of the hits on the list was GAPDH. This means that we must obtain a pure sample of GAPDH for use in future experiments to further validate the claim that these proteins interact. Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG,Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.

The Nuclear Imaging Detector Development group at the Department of Physics, University of Regina is developing Canada's first positron emission tomography (PET) system for plant physiological function studies In its current configuration the system consists of four detectors heads, each with active area of 48x48 mm2 In a typical arrangement the four detectors are grouped in two pairs of opposing heads for detecting coincident events from positron annihilation, however the system geometry, data acquisition and image reconstruction are flexible and can be easily reconfigured on-demand to accommodate other scanner configurations The detector pairs can be scanned along the vertical axis allowing to image plants up to 50 cm tall, while the plant within the Field of View (FOV) of the scanner can be rotated on a precision controlled motorized platform to provide a complete 3D coverage of the plant Current development and characterization of the plant PET system will be presented.

This work investigated the impact of corporate governance on employee productivity with special focus on gender diversity in selected Nigerian local banks whose operating licences predated 2006. The study adopted quantitative approach; applied descriptive and inferential statistical analyses; and extracted data from the sampled banks’ audited annual accounts from 2012 to 2016. Four hypotheses were developed in line with reviewed literature, and tested using multiple regression analysis and univariate general linear model. The study anchored on critical mass and upper echelon theories. The results reveal that: (i) board gender diversity has significant positive effect on Nigerian banks’ employee productivity; (ii) top-management gender diversity does not have significant effect on Nigerian banks’ employee productivity; (iii) board chairman gender diversity has significant positive effect on Nigerian banks’ employee productivity; and (iv) board secretary gender diversity does not have significant effect on Nigerian banks’ employee productivity. The practical implications of this research are that Nigerian banks should promote board gender diversity and board chairmen gender diversity to increase their employee productivity. Theoretically, this research establishes the importance of critical mass theory on Nigerian banking sector: board gender diversity has significant effect on employee productivity.