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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Sidorek, Krzysztof;

    Fotografie wykonane głównie w Warszawie w latach 90-tych.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Repozytorium Uniwers...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • Lesseur, Corina; Diergaarde, Brenda; Olshan, Andrew F; Wünsch-Filho, Victor; +50 Authors

    We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    Показано місце збиральництва в структурі традиційної господарської діяльності та в системі життєзабезпечення населення України, регіони найбільшого поширення збиральництва. Проаналізовано форми збиральництва (збирання ягід, грибів, трав, диких плодів, соків дерев). Звертається увага на звичаї й обряди, пов’язані із збиранням різних дарів природи.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Electronic Eastern E...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Pabiańska, Agnieszka;

    Prezentacja finałowa pierwszej polskiej edycji konkursu Three Minute Thesis®. Łódź, kwiecień 2014 (3MT® - FINAŁ 2014 - Agnieszka Pabiańska - I miejsce, Uniwersytet Łódzki).Organizatorzy konkursu: Boost Biotech Polska, Łódź Kreuje, Politechnika Łódzka, Uniwersytet Łódzki, Uniwersytet Medyczny w Łodzi. Realizator filmu konkursowego: ŁÓDŹ FILM.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Repozytorium Uniwers...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Miernicka, Irmina;

    Prezentacja finałowa III polskiej edycji konkursu Three Minute Thesis®. Łódź, listopad 2016. FINAŁ 2016 - Irmina Miernicka (Uniwersytet Łódzki) - I miejsce. Eliminacje na Uniwersytecie Łódzkim - II miejsce oraz nagroda publiczności. Organizator: Stowarzyszenie Boost Biotech Polska; Partnerzy: Politechnika Łódzka, Uniwersytet Łódzki, Uniwersytet Medyczny w Łodzi, Promuje Łódzkie, Młodzi w Łodzi; Patroni: Portal dlaStudenta.pl, TV TOYA, Wiedza i Życie, Studenckie Radio Żak Politechniki Łódzkiej. Elsevier, Fumed

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Repozytorium Uniwers...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Potz, Maciej;

    This is an exchange of letters between Leo Tolstoj and the Shakers, American communitarian religious groups. I transcribed them from original manuscripts or microfilms during my research at the Shaker library, Sabbathday Lake, Maine, USA in 2009. The main themes are Christian ethics, pacifism, non-violence etc., reflecting Tolstoj's interpretation of Christianity and the group's communal experience. Jest to, niepełny, zapis korespondencji między Lwem Tołstojem a shakerami, amerykańską wspólnotową grupą chrześcijańską. Transkrypcji z oryginalnych manuskryptów lub mikrofilmów dokonałem podczas pobytu na kwerendzie w Shaker LIbrary w Sabbathday Lake, Maine, USA w 2009 r. Główne tematy listów to etyka chrześcijańska, pacyfizm, niestosowanie przemocy itd., co odzwierciedla, z jednej strony, radykalną tołstojowską interpretację chrześcijaństwa, z drugiej zaś doświadczenia wspólnotowego życia shakerów. This research was financed by the Foundation for Polish Science, within the "Kwerenda" program. (Badania te zostały sfinansowane przez Fundację Nauki Polskiej w ramach programu "Kwerenda")

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Repozytorium Uniwers...arrow_drop_down
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Marciniak, Beata;

    Obiecującą perspektywą dla skuteczności leczenia nowotworów jest łączenie klasycznej chemioterapii z terapią ukierunkowaną na różne cele molekularne. Zastosowanie inhibitorów białek zaangażowanych w ścieżki sygnalizacyjne, związane z powstawaniem i rozwojem nowotworu, może wpłynąć na skuteczność i specyficzność stosowanych leków. Fosfataza DUSP6 jest białkiem, którego rola w procesie nowotworzenia jest niejednoznaczna. Wskazuje się zarówno na jej właściwości supresyjne, jak i onkogenne. Celem projektu badawczego była ocena wpływu inhibitora fosfatazy DUSP6 (BCI) na stopień cytotoksyczności onkoterapeutyków – irinotekanu i oksaliplatyny w komórkach raka jelita grubego, w układzie in vitro. W badaniu wykorzystano dwie ludzkie linie komórkowe, różniące się statusem genu BRCA2, a tym samym zdolnością do naprawy uszkodzeń DNA – DLD1 oraz DLD1 BRCA2 (-/-). Układy badawcze rozszerzono o zastosowanie inhibitora kinazy serynowo-treoninowej ATM (KU60019), będącej jednym z kluczowych białek mechanizmu naprawy DNA. W pierwszym etapie badań, dokonano oceny cytotoksyczności (test MTT) pojedynczych związków, a następnie ich układów. Oceniono wpływ wybranych stężeń BCI na właściwości chemioterapeutyków, również w obecności inhibitora ATM. W kolejnym etapie, wybrane układy doświadczalne poddano analizie cytometrycznej (Alexa Fluor®488 Annexin V/Dead Cell Apoptosis Kit), celem sprawdzenia ich aktywności w badanych komórkach oraz wskazania, jakiego rodzaju śmierć komórkową indukują. Combining traditional chemotherapy with treatments that focus on different molecular targets is a useful approach to enhance the effectiveness of cancer treatments. The efficiency and specificity of drugs can be affected by the use of inhibitors of proteins that are involved in signaling pathways associated with cancer development. DUSP6 is a phosphatase protein with an ambiguous role in tumorigenesis. It was found to have both suppressive and oncogenic properties. This research project aimed to evaluate the effect of the phosphatase DUSP6 inhibitor (BCI) on the cytotoxicity of the therapeutical agents used in cancer treatment (irinotecan and oxaliplatin) in colorectal cancer cells in vitro. Two cell lines differing in BRCA2 gene status and DNA repair capacity were used in the study – DLD1 and DLD1 BRCA2 (-/-). The research was extended with the use of ATM kinase inhibitor (KU60019), one of the key proteins involved in cellular DNA repair mechanisms. The cytotoxicity of the individual compounds (MTT assay) was analyzed in the first stage of the study, followed by the investigation of the cytotoxicity of the compounds in combinations. The effect of selected concentrations of BCI on the properties of chemotherapeutics was assessed, also in the presence of an ATM inhibitor. In the next step, selected compound combinations were subjected to cytometric analysis (Alexa Fluor®488 Annexin V/Dead Cell Apoptosis Kit) to evaluate their activity in the studied cells and to indicate the type of cell death that they can induce. NCN 2021/05/X/NZ3/01147

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Repozytorium Uniwers...arrow_drop_down
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Pawlak, Daniel;

    Prezentacja finałowa III polskiej edycji konkursu Three Minute Thesis®. Łódź, listopad 2016. FINAŁ 2016 - Daniel Pawlak (Uniwersytet Łódzki). Eliminacje na Uniwersytecie Łódzkim - I miejsce. Organizator: Stowarzyszenie Boost Biotech Polska; Sponsorzy: Izodom 2000 Polska, Elsevier, Fumed; Partnerzy: Politechnika Łódzka, Uniwersytet Łódzki, Uniwersytet Medyczny w Łodzi, Promuje Łódzkie, Młodzi w Łodzi; Patroni: Portal dlaStudenta.pl, TV TOYA, Wiedza i Życie, Studenckie Radio Żak Politechniki Łódzkiej. Izodom 2000 Polska, Elsevier, Fumed

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Repozytorium Uniwers...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    Відеоурок, раніше опублікований https://www.youtube.com/watch?v=dj1ZBNr1VYE

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Electronic Archive o...arrow_drop_down
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    Marco, Cinelli; Burgherr Peter; Kadzi��ski Mi��osz; S��owi��ski Roman;

    Case studies used in the test of the MCDA-MSS, described according to its 156 features.

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101 Research products
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Sidorek, Krzysztof;

    Fotografie wykonane głównie w Warszawie w latach 90-tych.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Repozytorium Uniwers...arrow_drop_down
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  • Lesseur, Corina; Diergaarde, Brenda; Olshan, Andrew F; Wünsch-Filho, Victor; +50 Authors

    We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/

    Показано місце збиральництва в структурі традиційної господарської діяльності та в системі життєзабезпечення населення України, регіони найбільшого поширення збиральництва. Проаналізовано форми збиральництва (збирання ягід, грибів, трав, диких плодів, соків дерев). Звертається увага на звичаї й обряди, пов’язані із збиранням різних дарів природи.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Electronic Eastern E...arrow_drop_down
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    Pabiańska, Agnieszka;

    Prezentacja finałowa pierwszej polskiej edycji konkursu Three Minute Thesis®. Łódź, kwiecień 2014 (3MT® - FINAŁ 2014 - Agnieszka Pabiańska - I miejsce, Uniwersytet Łódzki).Organizatorzy konkursu: Boost Biotech Polska, Łódź Kreuje, Politechnika Łódzka, Uniwersytet Łódzki, Uniwersytet Medyczny w Łodzi. Realizator filmu konkursowego: ŁÓDŹ FILM.

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    Miernicka, Irmina;

    Prezentacja finałowa III polskiej edycji konkursu Three Minute Thesis®. Łódź, listopad 2016. FINAŁ 2016 - Irmina Miernicka (Uniwersytet Łódzki) - I miejsce. Eliminacje na Uniwersytecie Łódzkim - II miejsce oraz nagroda publiczności. Organizator: Stowarzyszenie Boost Biotech Polska; Partnerzy: Politechnika Łódzka, Uniwersytet Łódzki, Uniwersytet Medyczny w Łodzi, Promuje Łódzkie, Młodzi w Łodzi; Patroni: Portal dlaStudenta.pl, TV TOYA, Wiedza i Życie, Studenckie Radio Żak Politechniki Łódzkiej. Elsevier, Fumed

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    Potz, Maciej;

    This is an exchange of letters between Leo Tolstoj and the Shakers, American communitarian religious groups. I transcribed them from original manuscripts or microfilms during my research at the Shaker library, Sabbathday Lake, Maine, USA in 2009. The main themes are Christian ethics, pacifism, non-violence etc., reflecting Tolstoj's interpretation of Christianity and the group's communal experience. Jest to, niepełny, zapis korespondencji między Lwem Tołstojem a shakerami, amerykańską wspólnotową grupą chrześcijańską. Transkrypcji z oryginalnych manuskryptów lub mikrofilmów dokonałem podczas pobytu na kwerendzie w Shaker LIbrary w Sabbathday Lake, Maine, USA w 2009 r. Główne tematy listów to etyka chrześcijańska, pacyfizm, niestosowanie przemocy itd., co odzwierciedla, z jednej strony, radykalną tołstojowską interpretację chrześcijaństwa, z drugiej zaś doświadczenia wspólnotowego życia shakerów. This research was financed by the Foundation for Polish Science, within the "Kwerenda" program. (Badania te zostały sfinansowane przez Fundację Nauki Polskiej w ramach programu "Kwerenda")

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    Marciniak, Beata;

    Obiecującą perspektywą dla skuteczności leczenia nowotworów jest łączenie klasycznej chemioterapii z terapią ukierunkowaną na różne cele molekularne. Zastosowanie inhibitorów białek zaangażowanych w ścieżki sygnalizacyjne, związane z powstawaniem i rozwojem nowotworu, może wpłynąć na skuteczność i specyficzność stosowanych leków. Fosfataza DUSP6 jest białkiem, którego rola w procesie nowotworzenia jest niejednoznaczna. Wskazuje się zarówno na jej właściwości supresyjne, jak i onkogenne. Celem projektu badawczego była ocena wpływu inhibitora fosfatazy DUSP6 (BCI) na stopień cytotoksyczności onkoterapeutyków – irinotekanu i oksaliplatyny w komórkach raka jelita grubego, w układzie in vitro. W badaniu wykorzystano dwie ludzkie linie komórkowe, różniące się statusem genu BRCA2, a tym samym zdolnością do naprawy uszkodzeń DNA – DLD1 oraz DLD1 BRCA2 (-/-). Układy badawcze rozszerzono o zastosowanie inhibitora kinazy serynowo-treoninowej ATM (KU60019), będącej jednym z kluczowych białek mechanizmu naprawy DNA. W pierwszym etapie badań, dokonano oceny cytotoksyczności (test MTT) pojedynczych związków, a następnie ich układów. Oceniono wpływ wybranych stężeń BCI na właściwości chemioterapeutyków, również w obecności inhibitora ATM. W kolejnym etapie, wybrane układy doświadczalne poddano analizie cytometrycznej (Alexa Fluor®488 Annexin V/Dead Cell Apoptosis Kit), celem sprawdzenia ich aktywności w badanych komórkach oraz wskazania, jakiego rodzaju śmierć komórkową indukują. Combining traditional chemotherapy with treatments that focus on different molecular targets is a useful approach to enhance the effectiveness of cancer treatments. The efficiency and specificity of drugs can be affected by the use of inhibitors of proteins that are involved in signaling pathways associated with cancer development. DUSP6 is a phosphatase protein with an ambiguous role in tumorigenesis. It was found to have both suppressive and oncogenic properties. This research project aimed to evaluate the effect of the phosphatase DUSP6 inhibitor (BCI) on the cytotoxicity of the therapeutical agents used in cancer treatment (irinotecan and oxaliplatin) in colorectal cancer cells in vitro. Two cell lines differing in BRCA2 gene status and DNA repair capacity were used in the study – DLD1 and DLD1 BRCA2 (-/-). The research was extended with the use of ATM kinase inhibitor (KU60019), one of the key proteins involved in cellular DNA repair mechanisms. The cytotoxicity of the individual compounds (MTT assay) was analyzed in the first stage of the study, followed by the investigation of the cytotoxicity of the compounds in combinations. The effect of selected concentrations of BCI on the properties of chemotherapeutics was assessed, also in the presence of an ATM inhibitor. In the next step, selected compound combinations were subjected to cytometric analysis (Alexa Fluor®488 Annexin V/Dead Cell Apoptosis Kit) to evaluate their activity in the studied cells and to indicate the type of cell death that they can induce. NCN 2021/05/X/NZ3/01147

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    Pawlak, Daniel;

    Prezentacja finałowa III polskiej edycji konkursu Three Minute Thesis®. Łódź, listopad 2016. FINAŁ 2016 - Daniel Pawlak (Uniwersytet Łódzki). Eliminacje na Uniwersytecie Łódzkim - I miejsce. Organizator: Stowarzyszenie Boost Biotech Polska; Sponsorzy: Izodom 2000 Polska, Elsevier, Fumed; Partnerzy: Politechnika Łódzka, Uniwersytet Łódzki, Uniwersytet Medyczny w Łodzi, Promuje Łódzkie, Młodzi w Łodzi; Patroni: Portal dlaStudenta.pl, TV TOYA, Wiedza i Życie, Studenckie Radio Żak Politechniki Łódzkiej. Izodom 2000 Polska, Elsevier, Fumed

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    Відеоурок, раніше опублікований https://www.youtube.com/watch?v=dj1ZBNr1VYE

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    Marco, Cinelli; Burgherr Peter; Kadzi��ski Mi��osz; S��owi��ski Roman;

    Case studies used in the test of the MCDA-MSS, described according to its 156 features.

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