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Research data keyboard_double_arrow_right Bioentity 2017 WT | Open access research to p... (092809), CIHR, UKRI | Industrial Doctorate Cent... (EP/G037280/1)N.M.Pearce; T.Krojer; R.Talon; A.R.Bradley; M.Fairhead; R.Sethi; N.Wright; E.Maclean; P.Collins; J.Brandao-Neto; A.Douangamath; Z.Renjie; A.Dias; M.Vollmar; J.Ng; P.E.Brennan; O.Cox; C.Bountra; C.H.Arrowsmith; A.Edwards; F.Von Delft;Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::97d362e412260b4cb795735e6a2dbca1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Audiovisual 2021figshare CIHRKang, Sang-Gyun; Han, Zhuang Zhuang; Daude, Nathalie; McNamara, Emily; Wohlgemuth, Serene; Molina-Porcel, Laura; Safar, Jiri G.; Mok, Sue-Ann; Westaway, David;Additional file 19: Supplementary Movie 12. Description: Time-lapse imaging of GFP-0N4R reporter cells seeded with S1 brain fractions including pathogenic tau derived from aged TgTauP301L mice with neurological signs. Images were obtained for 16 hours (10 min/frame for 96 frames). Scale bars, 10 μm.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.16599591.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average 
Powered by BIP!Research data keyboard_double_arrow_right Bioentity 2017 CIHR, UKRI | Industrial Doctorate Cent... (EP/G037280/1), WT | Open access research to p... (092809)Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::5f31d5fca646ce1deed91625013831d9&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Image 2017Figshare NSERC, CIHRFu, Wen; Vukojevic, Vlatka; Patel, Aarti; Soudy, Rania; MacTavish, David; Westaway, David; Kaur, Kamaljit; Goncharuk, Valeri; Jhamandas, Jack;A, Western blot showing AMY3 transfected HEK293 cells demonstrate a marked increase in level of expression of CTR and RAMP3 proteins compared to wild-type (WT) HEK cells. B, in BV2 cells, RAMP3 protein expression shows a marked decreased after RAMP3 siRNA transfection compared to the control non-transfected cells. (JPEG 1495 kb)
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.c.3899038_d2&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Bioentity 2017 NSERC, CIHRS.M.L.Gagnon; R.J.Blackler;S.M.L.Gagnon; R.J.Blackler;Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::cd5b9094b9a594d1e87395f24f23eb2e&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Dataset 2018figshare NSERC, CIHRSkinnider, Michael; Johnston, Chad; Nishanth Merwin; Dejong, Chris; Magarvey, Nathan;Complete set of 739 unique cyclodipeptide synthases identified in a global analysis of publicly available prokaryotic genomes. (XLSX 144Â kb)
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.5788746&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Bioentity 2017 NSERC, CIHRDo the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::8f3a6791dc5025f6b450d7f6c33bbc13&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Image 2019Figshare CIHRSubodh Verma; Rawat, Sonia; Ho, Kim L.; Wagg, Cory S.; Liyan Zhang; Hwee Teoh; Dyck, John E.; Golam M. Uddin; Oudit, Gavin Y.; Mayoux, Eric; Lehrke, Michael; Marx, Nikolaus; Lopaschuk, Gary D.;Metabolic rates are shown for palmitate oxidation (n = 8 to 10/group) (A), glucose oxidation (n = 8 to 10/group) (B), glycolysis (8 to 9/group) (C), β-hydroxybutyrate (βOHB) oxidation (n = 8 to 9/group) (D), and total adenosine triphosphate (ATP) production (8 to 10/group) (E). Cardiac efficiency calculated as cardiac work/O2 consumed (n = 9 to 12/group) (F) is also shown. Data are presented as mean ± SEM. Data were analyzed by 1-way ANOVA to determine differences within the same insulin status and between groups in the presence or absence of insulin followed by LSD post hoc test. Four separate 1-way ANOVAs were performed to determine each substrate’s contribution to ATP production. Cardiac efficiency was analyzed by repeated 1-way ANOVA followed by LSD post hoc test. *p < 0.05 was considered as a significantly different comparison with C57BL/6J + Vehicle. For E, ‡p < 0.05 was considered as a significantly different in comparison with C57BL/6J + Vehicle within the same insulin status. Abbreviations as in Figure 1.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25407/jacbts.8262176.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Bioentity 2017 UKRI | Industrial Doctorate Cent... (EP/G037280/1), WT | Open access research to p... (092809), CIHRDo the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::73d01d43536d6352cf2b8245214b9064&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Bioentity 2017 CIHR, WTDo the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::2139ec41be8487daf4be90dbc4c294ab&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu
5,629 Research products
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Research data keyboard_double_arrow_right Bioentity 2017 WT | Open access research to p... (092809), CIHR, UKRI | Industrial Doctorate Cent... (EP/G037280/1)N.M.Pearce; T.Krojer; R.Talon; A.R.Bradley; M.Fairhead; R.Sethi; N.Wright; E.Maclean; P.Collins; J.Brandao-Neto; A.Douangamath; Z.Renjie; A.Dias; M.Vollmar; J.Ng; P.E.Brennan; O.Cox; C.Bountra; C.H.Arrowsmith; A.Edwards; F.Von Delft;Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::97d362e412260b4cb795735e6a2dbca1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Audiovisual 2021figshare CIHRKang, Sang-Gyun; Han, Zhuang Zhuang; Daude, Nathalie; McNamara, Emily; Wohlgemuth, Serene; Molina-Porcel, Laura; Safar, Jiri G.; Mok, Sue-Ann; Westaway, David;Additional file 19: Supplementary Movie 12. Description: Time-lapse imaging of GFP-0N4R reporter cells seeded with S1 brain fractions including pathogenic tau derived from aged TgTauP301L mice with neurological signs. Images were obtained for 16 hours (10 min/frame for 96 frames). Scale bars, 10 μm.
figshare arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.16599591.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Bioentity 2017 CIHR, UKRI | Industrial Doctorate Cent... (EP/G037280/1), WT | Open access research to p... (092809)Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::5f31d5fca646ce1deed91625013831d9&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Image 2017Figshare NSERC, CIHRFu, Wen; Vukojevic, Vlatka; Patel, Aarti; Soudy, Rania; MacTavish, David; Westaway, David; Kaur, Kamaljit; Goncharuk, Valeri; Jhamandas, Jack;A, Western blot showing AMY3 transfected HEK293 cells demonstrate a marked increase in level of expression of CTR and RAMP3 proteins compared to wild-type (WT) HEK cells. B, in BV2 cells, RAMP3 protein expression shows a marked decreased after RAMP3 siRNA transfection compared to the control non-transfected cells. (JPEG 1495 kb)
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.c.3899038_d2&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Bioentity 2017 NSERC, CIHRS.M.L.Gagnon; R.J.Blackler;S.M.L.Gagnon; R.J.Blackler;Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::cd5b9094b9a594d1e87395f24f23eb2e&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Dataset 2018figshare NSERC, CIHRSkinnider, Michael; Johnston, Chad; Nishanth Merwin; Dejong, Chris; Magarvey, Nathan;Complete set of 739 unique cyclodipeptide synthases identified in a global analysis of publicly available prokaryotic genomes. (XLSX 144Â kb)
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.6084/m9.figshare.5788746&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Bioentity 2017 NSERC, CIHRDo the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::8f3a6791dc5025f6b450d7f6c33bbc13&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Image 2019Figshare CIHRSubodh Verma; Rawat, Sonia; Ho, Kim L.; Wagg, Cory S.; Liyan Zhang; Hwee Teoh; Dyck, John E.; Golam M. Uddin; Oudit, Gavin Y.; Mayoux, Eric; Lehrke, Michael; Marx, Nikolaus; Lopaschuk, Gary D.;Metabolic rates are shown for palmitate oxidation (n = 8 to 10/group) (A), glucose oxidation (n = 8 to 10/group) (B), glycolysis (8 to 9/group) (C), β-hydroxybutyrate (βOHB) oxidation (n = 8 to 9/group) (D), and total adenosine triphosphate (ATP) production (8 to 10/group) (E). Cardiac efficiency calculated as cardiac work/O2 consumed (n = 9 to 12/group) (F) is also shown. Data are presented as mean ± SEM. Data were analyzed by 1-way ANOVA to determine differences within the same insulin status and between groups in the presence or absence of insulin followed by LSD post hoc test. Four separate 1-way ANOVAs were performed to determine each substrate’s contribution to ATP production. Cardiac efficiency was analyzed by repeated 1-way ANOVA followed by LSD post hoc test. *p < 0.05 was considered as a significantly different comparison with C57BL/6J + Vehicle. For E, ‡p < 0.05 was considered as a significantly different in comparison with C57BL/6J + Vehicle within the same insulin status. Abbreviations as in Figure 1.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.25407/jacbts.8262176.v1&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!Research data keyboard_double_arrow_right Bioentity 2017 UKRI | Industrial Doctorate Cent... (EP/G037280/1), WT | Open access research to p... (092809), CIHRDo the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::73d01d43536d6352cf2b8245214b9064&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euResearch data keyboard_double_arrow_right Bioentity 2017 CIHR, WTDo the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=pdb_________::2139ec41be8487daf4be90dbc4c294ab&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu