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  • Purpose: The goal of this study was to assess the status of splicing changes in microexons in the cortex of individuals with autism. Methods: We performed RiboZero Gold (rRNA depleted) 50bp PE RNA-seq in a larger set of case and control samples to define 12 autism and 1...

  • This study was included as part of a GWAS consortium. Diet, Activity, and Lifestyle Study (DALS) is a case-control study comprised of patients recruited from 3 locations from 1991-1994. Cases included those with first primary colon cancer diagnosis, an age at diagnosis ...

  • STARNET is a genetics of RNA expression study of multiple disease-relevant tissues obtained from living patients with cardiovascular disease. Tissue samples are obtained from blood, atherosclerotic-lesion-free internal mammary artery (MAM) and atherosclerotic aortic roo...

  • The goal of this study was to determine the genetics underlying blond hair in the Solomon Islands, which has the highest prevalence of blondism outside of Europe. Participants in the study were of self-reported Solomon Islands ancestry and were 6-36 years of age at enro...

  • research data . 2019
    Open Access English
    Authors:
    Johnson, Nicholas D.; Luoxiu Huang; Ronghua Li; Li, Yun; Yuchen Yang; Kim, Hye Rim; Grant, Crystal; Wu, Hao; Whitsel, Eric A.; Kiel, Douglas P.; ...

    <p>DNA methylation (DNAm) has a well-established association with age in many tissues, including peripheral blood mononuclear cells (PBMCs). Compared to DNAm, the closely related epigenetic modification known as DNA hydroxymethylation (DNAhm) was much more recently disc...

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  • <p>The third leading cause of death in the United States, stroke is an acute neurological event leading to death of neural tissues. Although the majority of strokes are ischemic strokes, meaning there is oxygen deprivation to the brain, almost 20% of strokes are hemorrh...

  • The aim of this study is to discover LINE-1 (L1) insertion sites present in humans that are absent from the reference genome sequence. We use the distinguishing nucleotide characteristics of human-specific L1 elements to resequence the L1 3 flanking regions thus locatin...

  • Schizophrenia is a common and severe psychotic disorder. While some common SNPs and rare copy number variants have been identified as being significantly associated with disease risk, the biological mechanisms remain undefined. To identify gene expression abnormalities ...

  • The National Human Genome Research Institute (NHGRI) has funded the Centers for Common Disease Genomics (CCDG), a collaborative large-scale genome sequencing effort to comprehensively identify rare risk and protective variants contributing to multiple common disease phe...

1,853 research outcomes, page 1 of 186