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Complete set of 739 unique cyclodipeptide synthases identified in a global analysis of publicly available prokaryotic genomes. (XLSX 144Â kb)

Alignment-based metrics for reverse transcriptase comparisons. Table S2. Alignment-based metrics for the size selection experiment. Table S3. Alignment-based metrics for the comparison of library construction kits. Table S4. Alignment-based metrics for the intermediate ssRNA-seq pipeline. The protocol evaluated includes all changes (1st strand cDNA synthesis, optimal bead purifications, new library construction chemistry with modified ligation condition, bead-based size selection, and UNG treatment) with the exception of the mRNA isolation improvements. Table S5. Alignment-based metrics for the final ssRNA-seq pipeline using UHR. Table S6. Alignment-based metrics for the final ssRNA-seq pipeline using tumor samples. (XLS 62Â kb)

Additional file 4: Table S3. A. Results for 34 independent ARIC Discovery Meta-Analysis identified mtDNA-CN associated CpGs across all studied cohorts and Validation Meta-Analysis/All Cohort Meta-Analysis. Validation meta-analysis included CHS AA, CHS EA and FHS EA cohorts (P

Targets for goal-directed action can be encoded in allocentric coordinates (relative to another visual landmark), but it is not known how these are converted into egocentric commands for action. Here, we investigated this using a slow event-related fMRI paradigm, based on our previous behavioral finding that the Allocentric to Egocentric (Allo-Ego) conversion for reach is done at the first possible opportunity. Participants were asked to remember (and eventually reach toward) the location of a briefly presented target relative to another visual landmark. After a 1st memory delay, participants were forewarned by a verbal instruction if the landmark would reappear at the same location, (potentially allowing them to plan a reach following the auditory cue before the 2nd delay), or at a different location where they had to wait for the final landmark to be presented before response, and then reach toward the remembered target location. As predicted, participants showed landmark-centered directional selectivity in occipital-temporal cortex during the first memory delay, only developed egocentric directional selectivity in occipital-parietal cortex during the second delay for the “Same cue” task, and during response for the “Different cue” task. We then compared cortical activation between these two tasks at the times when the Allo-Ego conversion occurred, and found common activation in right precuneus, right pre-supplementary area and bilateral dorsal premotor cortex. These results confirm that the brain converts allocentric codes to egocentric plans at the first possible opportunity, and identify the four most likely candidate sites specific to the Allo-Ego transformation for reaches.

Copy number variation (CNV) segments in primary and recurrence tumors from 8 of 16 pairs of pHGG with matched normal tissue available. (XLSX 71Â kb)

Test of relatedness - Table showing relatedness for each trio by comparing SNP concordance between child, mother and father. (XLSX 17 kb)

S1. Systematic review search strategy. Search terms, number of results, and filters used when collecting studies from databases for the systematic review. S2. Abstraction form and dataset. Abstraction form and dataset used for our analysis. (ZIP 148 kb)

Flow cytometric analyses of day 4 CD235a/Aldefluor and day20 MLC2V/CTNT expression of HES2 hESC (Figure S8) and MSC-iPS1 hiPSC lines (Figure S9)

Collections of cells called engrams are thought to represent memories. Although there has been progress in identifying and manipulating single engrams, little is known about how multiple engrams interact to influence memory. In lateral amygdala (LA), neurons with increased excitability during training outcompete their neighbors for allocation to an engram. We examined whether competition based on neuronal excitability also governs the interaction between engrams. Mice received two distinct fear conditioning events separated by different intervals. LA neuron excitability was optogenetically manipulated and revealed a transient competitive process that integrates memories for events occurring closely in time (coallocating overlapping populations of neurons to both engrams) and separates memories for events occurring at distal times (disallocating nonoverlapping populations to each engram). Rashid et al Science 2016- Data for Figs 1-4, S1-S9Excel file with all data presented in manuscript (each sheet corresponds to specific figures as indicated).Rashid et al Science 2016.xlsx