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  • Research data . 2021
    Restricted
    Authors: 
    Wenzhong, Shi; Chengzhuo, Tong; Anshu, Zhang; Zhicheng, Shi;
    Publisher: Zenodo

    All are about the original data or result data in the article of "A Spatial and Dynamic Solution for how to Allocate the COVID-19 Vaccine in the Context of Limited Supply"

  • Research data . 2021
    Restricted
    Authors: 
    Marija Petkovic;
    Publisher: Zenodo

    Proteomics data miR-146a

  • Restricted English
    Authors: 
    Dozio, Elena; Ruscica, Massimiliano; Vianello, Elena; Macchi, Chiara; Sitzia, Clementina; Schmitz, Gerd; Tacchini, Lorenza; Romanelli, Massimiliano M Corsi;
    Publisher: Zenodo

    Data set from the article Dozio E, Ruscica M, Vianello E, Macchi C, Sitzia C, Schmitz G, Tacchini L, Corsi Romanelli MM. PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation. Mediators Inflamm. 2020 Jun 4;2020:1348913. doi: 10.1155/2020/1348913. PMID: 32565719; PMCID: PMC7292972. Abstract Epicardial adipose tissue (EAT) has the unique property to release mediators that nourish the heart in healthy conditions, an effect that becomes detrimental when volume expands and proinflammatory cytokines start to be produced. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a proinflammatory mediator involved in atherosclerosis, is also produced by visceral fat. Due to the correlation of inflammation with PCSK9 and EAT enlargement, we evaluated whether PCSK9 was expressed in EAT and associated with EAT inflammation and volume. EAT samples were isolated during surgery. EAT thickness was measured by echocardiography. A microarray was used to explore EAT transcriptoma. The PCSK9 protein levels were measured by Western Blot in EAT and ELISA in plasma. PCSK9 was expressed at both the gene and protein levels in EAT. We found a positive association with EAT thickness and local proinflammatory mediators, in particular, chemokines for monocytes and lymphocytes. No association was found with the circulating PCSK9 level. The expression of PCSK9 in EAT argues that PCSK9 is part of the EAT secretome and EAT inflammation is associated with local PCSK9 expression, regardless of circulating PCSK9 levels. Whether reducing EAT inflammation or PCSK9 local levels may have beneficial effects on EAT metabolism and cardiovascular risk needs further investigations.

  • Research data . 2021
    Restricted English
    Authors: 
    Senbill, Haytham; Tanaka, Tetsuya; Karawia, Donia; Zeb, Jehan; Baruah, Aiswarya;
    Publisher: Zenodo

    Yes

  • Research data . 2021
    Restricted Hungarian
    Authors: 
    Palkó, Gábor; Indig, Balázs; Fellegi, Zsófia; Sárközi-Lindner, Zsófia;
    Publisher: Zenodo

    This object contains the most comprehensive curated version available at the date of publication. For further information on the content and for other fractions see: Abcúg.Please fill in the following form before requesting access to this dataset:ACCES FORM

  • Restricted English
    Authors: 
    Atemezing Ghislain; Icard Benjamin; Egré Paul;
    Publisher: Zenodo

    This resource contains the database used to detect vagueness in textual documents. It is represented in a list according to the gazetteers used in the GATE software. This lexical database has been developed and is maintained within the project DIEKB by Institut Jean-Nicod (Institut Jean, CNRS, ENS, EHESS, PSL University) and MONDECA. An online demo of the tool VAGO using this database is available at https://research.mondeca.com/demo/vago/.

  • Restricted
    Authors: 
    Chen, Jie; Zhang, Tao; Li, Huaiming; Tao, Chunhui; Cannat, Mathilde; Daniel Sauter;
    Publisher: Zenodo

    Mantle Bouguer gravity Anomaly (masked) in Figure 2d. Crustal thickness anomaly (masked) in Figure S2d. Crustal thickness anomaly (combined) in Figure S6.

  • Research data . Image . 2021
    Restricted
    Authors: 
    Ff;
    Publisher: Zenodo

    ff-demo ccbync

  • Restricted Dutch; Flemish
    Authors: 
    Morbée, Sofie;
    Publisher: Zenodo

    This upload contains all data, analysis code, and research materials.

  • Restricted English
    Authors: 
    Raphael Martins de Abreu; Aparecida Maria Catai; Beatrice Cairo; Patricia Rehder-Santos; Claudio Donisete da Silva; Étore De Favari Signini; Camila Akemi Sakaguchi; Alberto Porta;
    Publisher: Zenodo

    Datset from the article de Abreu RM, Catai AM, Cairo B, Rehder-Santos P, da Silva CD, Signini ÉF, Sakaguchi CA, Porta A. A Transfer Entropy Approach for the Assessment of the Impact of Inspiratory Muscle Training on the Cardiorespiratory Coupling of Amateur Cyclists. Front Physiol. 2020 Feb 25;11:134. doi: 10.3389/fphys.2020.00134. PMID: 32158402; PMCID: PMC7052290. Abstract The strength of cardiorespiratory interactions diminishes with age. Physical exercise can reduce the rate of this trend. Inspiratory muscle training (IMT) is a technique capable of improving cardiorespiratory interactions. This study evaluates the effect of IMT on cardiorespiratory coupling in amateur cyclists. Thirty male young healthy cyclists underwent a sham IMT of very low intensity (SHAM, n = 9), an IMT of moderate intensity at 60% of the maximal inspiratory pressure (MIP60, n = 10) and an IMT of high intensity at the critical inspiratory pressure (CIP, n = 11). Electrocardiogram, non-invasive arterial pressure, and thoracic respiratory movement (RM) were recorded before (PRE) and after (POST) training at rest in supine position (REST) and during active standing (STAND). The beat-to-beat series of heart period (HP) and systolic arterial pressure (SAP) were analyzed with the RM signal via a traditional non-causal approach, such as squared coherence function, and via a causal model-based transfer entropy (TE) approach. Cardiorespiratory coupling was quantified via the HP-RM squared coherence at the respiratory rate (K 2 HP-R M), the unconditioned TE from RM to HP (TER M → HP) and the TE from RM to HP conditioned on SAP (TER M → HP| SAP). In PRE condition we found that STAND led to a decrease of TER M → HP| SAP. After SHAM and CIP training this tendency was confirmed, while MIP60 inverted it by empowering cardiorespiratory coupling. This behavior was observed in presence of unvaried SAP mean and with usual responses of the baroreflex control and HP mean to STAND. TER M → HP and K 2 HP- RM were not able to detect the post-training increase of cardiorespiratory coupling strength during STAND, thus suggesting that conditioning out SAP is important for the assessment of cardiorespiratory interactions. Since the usual response of HP mean, SAP mean and baroreflex sensitivity to postural stressor were observed after MIP60 training, we conclude that the post-training increase of cardiorespiratory coupling during STAND in MIP60 group might be the genuine effect of some rearrangements at the level of central respiratory network and its interactions with sympathetic drive and vagal activity.

search
Include:
1,783 Research products, page 1 of 179
  • Research data . 2021
    Restricted
    Authors: 
    Wenzhong, Shi; Chengzhuo, Tong; Anshu, Zhang; Zhicheng, Shi;
    Publisher: Zenodo

    All are about the original data or result data in the article of "A Spatial and Dynamic Solution for how to Allocate the COVID-19 Vaccine in the Context of Limited Supply"

  • Research data . 2021
    Restricted
    Authors: 
    Marija Petkovic;
    Publisher: Zenodo

    Proteomics data miR-146a

  • Restricted English
    Authors: 
    Dozio, Elena; Ruscica, Massimiliano; Vianello, Elena; Macchi, Chiara; Sitzia, Clementina; Schmitz, Gerd; Tacchini, Lorenza; Romanelli, Massimiliano M Corsi;
    Publisher: Zenodo

    Data set from the article Dozio E, Ruscica M, Vianello E, Macchi C, Sitzia C, Schmitz G, Tacchini L, Corsi Romanelli MM. PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation. Mediators Inflamm. 2020 Jun 4;2020:1348913. doi: 10.1155/2020/1348913. PMID: 32565719; PMCID: PMC7292972. Abstract Epicardial adipose tissue (EAT) has the unique property to release mediators that nourish the heart in healthy conditions, an effect that becomes detrimental when volume expands and proinflammatory cytokines start to be produced. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a proinflammatory mediator involved in atherosclerosis, is also produced by visceral fat. Due to the correlation of inflammation with PCSK9 and EAT enlargement, we evaluated whether PCSK9 was expressed in EAT and associated with EAT inflammation and volume. EAT samples were isolated during surgery. EAT thickness was measured by echocardiography. A microarray was used to explore EAT transcriptoma. The PCSK9 protein levels were measured by Western Blot in EAT and ELISA in plasma. PCSK9 was expressed at both the gene and protein levels in EAT. We found a positive association with EAT thickness and local proinflammatory mediators, in particular, chemokines for monocytes and lymphocytes. No association was found with the circulating PCSK9 level. The expression of PCSK9 in EAT argues that PCSK9 is part of the EAT secretome and EAT inflammation is associated with local PCSK9 expression, regardless of circulating PCSK9 levels. Whether reducing EAT inflammation or PCSK9 local levels may have beneficial effects on EAT metabolism and cardiovascular risk needs further investigations.

  • Research data . 2021
    Restricted English
    Authors: 
    Senbill, Haytham; Tanaka, Tetsuya; Karawia, Donia; Zeb, Jehan; Baruah, Aiswarya;
    Publisher: Zenodo

    Yes

  • Research data . 2021
    Restricted Hungarian
    Authors: 
    Palkó, Gábor; Indig, Balázs; Fellegi, Zsófia; Sárközi-Lindner, Zsófia;
    Publisher: Zenodo

    This object contains the most comprehensive curated version available at the date of publication. For further information on the content and for other fractions see: Abcúg.Please fill in the following form before requesting access to this dataset:ACCES FORM

  • Restricted English
    Authors: 
    Atemezing Ghislain; Icard Benjamin; Egré Paul;
    Publisher: Zenodo

    This resource contains the database used to detect vagueness in textual documents. It is represented in a list according to the gazetteers used in the GATE software. This lexical database has been developed and is maintained within the project DIEKB by Institut Jean-Nicod (Institut Jean, CNRS, ENS, EHESS, PSL University) and MONDECA. An online demo of the tool VAGO using this database is available at https://research.mondeca.com/demo/vago/.

  • Restricted
    Authors: 
    Chen, Jie; Zhang, Tao; Li, Huaiming; Tao, Chunhui; Cannat, Mathilde; Daniel Sauter;
    Publisher: Zenodo

    Mantle Bouguer gravity Anomaly (masked) in Figure 2d. Crustal thickness anomaly (masked) in Figure S2d. Crustal thickness anomaly (combined) in Figure S6.

  • Research data . Image . 2021
    Restricted
    Authors: 
    Ff;
    Publisher: Zenodo

    ff-demo ccbync

  • Restricted Dutch; Flemish
    Authors: 
    Morbée, Sofie;
    Publisher: Zenodo

    This upload contains all data, analysis code, and research materials.

  • Restricted English
    Authors: 
    Raphael Martins de Abreu; Aparecida Maria Catai; Beatrice Cairo; Patricia Rehder-Santos; Claudio Donisete da Silva; Étore De Favari Signini; Camila Akemi Sakaguchi; Alberto Porta;
    Publisher: Zenodo

    Datset from the article de Abreu RM, Catai AM, Cairo B, Rehder-Santos P, da Silva CD, Signini ÉF, Sakaguchi CA, Porta A. A Transfer Entropy Approach for the Assessment of the Impact of Inspiratory Muscle Training on the Cardiorespiratory Coupling of Amateur Cyclists. Front Physiol. 2020 Feb 25;11:134. doi: 10.3389/fphys.2020.00134. PMID: 32158402; PMCID: PMC7052290. Abstract The strength of cardiorespiratory interactions diminishes with age. Physical exercise can reduce the rate of this trend. Inspiratory muscle training (IMT) is a technique capable of improving cardiorespiratory interactions. This study evaluates the effect of IMT on cardiorespiratory coupling in amateur cyclists. Thirty male young healthy cyclists underwent a sham IMT of very low intensity (SHAM, n = 9), an IMT of moderate intensity at 60% of the maximal inspiratory pressure (MIP60, n = 10) and an IMT of high intensity at the critical inspiratory pressure (CIP, n = 11). Electrocardiogram, non-invasive arterial pressure, and thoracic respiratory movement (RM) were recorded before (PRE) and after (POST) training at rest in supine position (REST) and during active standing (STAND). The beat-to-beat series of heart period (HP) and systolic arterial pressure (SAP) were analyzed with the RM signal via a traditional non-causal approach, such as squared coherence function, and via a causal model-based transfer entropy (TE) approach. Cardiorespiratory coupling was quantified via the HP-RM squared coherence at the respiratory rate (K 2 HP-R M), the unconditioned TE from RM to HP (TER M → HP) and the TE from RM to HP conditioned on SAP (TER M → HP| SAP). In PRE condition we found that STAND led to a decrease of TER M → HP| SAP. After SHAM and CIP training this tendency was confirmed, while MIP60 inverted it by empowering cardiorespiratory coupling. This behavior was observed in presence of unvaried SAP mean and with usual responses of the baroreflex control and HP mean to STAND. TER M → HP and K 2 HP- RM were not able to detect the post-training increase of cardiorespiratory coupling strength during STAND, thus suggesting that conditioning out SAP is important for the assessment of cardiorespiratory interactions. Since the usual response of HP mean, SAP mean and baroreflex sensitivity to postural stressor were observed after MIP60 training, we conclude that the post-training increase of cardiorespiratory coupling during STAND in MIP60 group might be the genuine effect of some rearrangements at the level of central respiratory network and its interactions with sympathetic drive and vagal activity.

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