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  • Other research product . 2020
    Open Access English
    Authors: 
    Reis, Pedro;
    Publisher: SpringerOpen
    Country: Portugal
    Project: WT

    The exercise of Environmental Citizenship is strongly associated with a citizen’s capacity to act in society as an agent of change (ENEC 2018), and this depends on the development of a person’s willingness and competence for a critical, active and democratic engagement in preventing and solving environmental problems. There is a call for a citizenry that is well informed and empowered to take appropriate actions on the seriousness of the environmental problems affecting our world (Gray et al. 2009; Hodson 2003). However, many citizens do not feel empowered enough to participate in decision-making processes regarding socio-environmental issues, and, at the same time, the faith and trust in politicians have decreased, and political apathy is gaining ground (Hodson 2014). Throughout the past decade, the surge in authoritarian government practices, the failure of popular movements to replace undemocratic regimes and the increase in populist movements all over the world are fuelling concerns about a possible ‘democratic recession’ (Diamond 2015). Part of the success of this movement has been credited to the failures in mobilising young people’s political participation (Schulz et al. 2018; Jackson et al. 2016). Civic engagement depends on students and their ‘motivation to participate in civic activities, their confidence in the effectiveness of their participation, and their beliefs about their own capacity to become actively involved’ (Schulz et al. 2018, p. 72). Research shows that a student’s civic engagement can be supported and encouraged by school, with the help of (1) open school climates, (2) democratic structures within schools and (3) early opportunities for active participation, the promotion of students’ civic knowledge and the predisposition to engage in civic activities in the future (Schulz et al. 2018; Pancer 2015; Roth and Barton 2004). Therefore, education represents a key element in counteracting low levels of civic engagement among young people, namely, through the promotion of democratic activism (Hodson 2014).

  • Open Access English
    Authors: 
    Wathuo, Miriam; Medley, Graham; Nokes, D. James; Munywoki, Patrick K.;
    Publisher: F1000Research
    Country: United Kingdom
    Project: WT | Household transmission of... (090853), WT | Defining pathways of resp... (102975)

    Background: A better understanding of respiratory syncytial virus (RSV) epidemiology requires realistic estimates of RSV shedding patterns, quantities shed, and identification of the related underlying factors.\ud \ud Methods: RSV infection data arise from a cohort study of 47 households with 493 occupants, in coastal Kenya, during the 2009/2010 RSV season. Nasopharyngeal swabs were taken every 3 to 4 days and screened for RSV using a real time polymerase chain reaction (PCR) assay. The amount of virus shed was quantified by calculating the ‘area under the curve’ using the trapezoidal rule applied to rescaled PCR cycle threshold output. Multivariable linear regression was used to identify correlates of amount of virus shed.\ud \ud Results: The median quantity of virus shed per infection episode was 29.4 (95% CI: 15.2, 54.2) log10 ribonucleic acid (RNA) copies. Young age (<1 year), presence of upper respiratory symptoms, intra-household acquisition of infection, an individual’s first infection episode in the RSV season, and having a co-infection of RSV group A and B were associated with increased amount of virus shed.\ud \ud Conclusions: The findings provide insight into which groups of individuals have higher potential for transmission, information which may be useful in designing RSV prevention strategies.

  • Open Access English
    Authors: 
    Deans, Zandra C.; Costa, Jose Luis; Cree, Ian; Dequeker, Els; Edsjo, Anders; Henderson, Shirley; Hummel, Michael; Ligtenberg, Marjolijn J. L.; Loddo, Marco; Machado, Jose Carlos; +12 more
    Project: WT

    The clinical demand for mutation detection within multiple genes from a single tumour sample requires molecular diagnostic laboratories to develop rapid, high-throughput, highly sensitive, accurate and parallel testing within tight budget constraints. To meet this demand, many laboratories employ next-generation sequencing (NGS) based on small amplicons. Building on existing publications and general guidance for the clinical use of NGS and learnings from germline testing, the following guidelines establish consensus standards for somatic diagnostic testing, specifically for identifying and reporting mutations in solid tumours. These guidelines cover the testing strategy, implementation of testing within clinical service, sample requirements, data analysis and reporting of results. In conjunction with appropriate staff training and international standards for laboratory testing, these consensus standards for the use of NGS in molecular pathology of solid tumours will assist laboratories in implementing NGS in clinical services.

  • Open Access English
    Authors: 
    Bauer, Bruno; Stieg, Kerstin;
    Publisher: Transilvania University of Brasov
    Project: WT

    The following article provides an overview of Open Access Publishing in Austria in 2010. First of all, the participation of Austrian institutions in signing Open Access declarations and Open Access events in Austria are presented. Secondly, the article shows the development of both the Green Road to Open Access (repositories) as well as the Golden Road (Open Access Journals) in Austria. The article also describes the Open Access policies of the most important funding agency in Austria, the biggest university of the country as well as Universities Austria, the association of the 21 public universities in Austria. Finally, the paper raises the question of how Open Access is to be financed and explains the legal framework conditions for Open Access in Austria.

  • Open Access English
    Authors: 
    Cayla, Mathieu; Matthews, Keith R.; Ivens, Alasdair C.;
    Publisher: Zenodo
    Project: WT | Environmental sensing and... (103740), WT | Environmental sensing and... (103740)

    Underlying dataset for the identifications of low-complexity regions (LCRs) in the proteome of Trypanosoma brucei. - Supplement File 2.xlsx (Position of every InterPro domain and LCR identified. All genes are provided with indication on chromosome localisation, presence of transmembrane domains, signal peptides and the localisation of the encoded proteins, either predicted using DeepLoc37 or observed (Tryptag38)). - Supplement File 3.xlsx (List of genes and Molecular Function gene ontology (GO) enrichment analysis of proteins with predicted LCRs in the N-terminal, central part or C-terminal or the different possible combinations.) - Supplement File 4.xlsx (Property analysis of sequences of every InterPro and LCRs identified.) - Supplement File 5.xlsx (List of genes and Molecular GO enrichment analysis of proteins presenting a Low (<8) or High (>9) polarity index level.) - Supplement File 6.xlsx (List and position of PTMs present on InterPro domains and LCRs. The different datasets from which the PTMs have been extracted can be found in the Zhang2020, Benz2019, Cayla2019, Urbaniak2013, Ooi2020, Fisk2012, Lott2012 and Moretti201712,13,15,17–19,27,28 columns. The sequence properties of the domains/LCRs on which these PTMs are located are also indicated. The list of modifications identified in Ooi et al. 202028 present on LCRs are indicated in the second sheet.) - Supplement File 7.xlsx (List and position of LCRs, signal peptides and their overlap.) {"references": ["Cayla et al (2020). A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation. Wellcome Open Res, 5:219 (https://doi.org/10.12688/wellcomeopenres.16286.1)"]} This work was also supported by the Marie Sklodowska Curie postdoctoral fellowship (proposal number 65470) and a Royal Society Research merit award [WM140045]

  • Other research product . Other ORP type . 2015
    Open Access English
    Authors: 
    Dijk, E.M.S.; Dimitropoulos, Harry; Iatropoulou, Katerina; Foufoulas, Ioannis;
    Publisher: OpenAIRE2020
    Project: WT , EC | OpenAIRE2020 (643410)

    This deliverable relates to the work carried out under task T8.3, “Research Impact Services”. The task’s focus is on the development of pilots with selected National funding agencies and infrastructure initiatives in order to serve them with the OpenAIRE research impact suite of services. A major service that OpenAIRE provides is the linking of research results to funding. Aside from importing the links from the repositories and journals, OpenAIRE designs, develops and enhances mining algorithms that identify and extract funding information from the text of scientific publications. With the help of NOADs we have initiated bi-lateral, often informal, collaborations with national funding agencies to facilitate mining extraction on their data. This is an on-going activity throughout the duration of the project. Currently the national funding agencies that we are working with are: FCT (Portugal), ARC (Australia), NHMRC (Australia), NSF & NIH (USA), SFI (Ireland), “Ministry of Science Education and Sport” & "Croatian Science Foundation” (Croatia), NWO (Netherlands), and DFG (Germany). This deliverable describes the nature of the data of the identified National funding agencies, as well as their export technologies, and provides the specification of the general-purpose OpenAIRE services required to support research impact measurements.

  • Open Access English
    Authors: 
    Reddy, Akhilesh B.;
    Publisher: Springer International Publishing
    Project: WT
  • Open Access English
    Authors: 
    Highton, David; Tachtsidis, Ilias; Tucker, Alison; Elwell, Clare; Smith, Martin;
    Publisher: Springer New York
    Project: WT
  • Other research product . Other ORP type . 2009
    Open Access English
    Authors: 
    Curtis, Lesley A.;
    Publisher: Personal Social Services Research Unit, University of Kent
    Country: United Kingdom
    Project: WT

    This is the seventeenth volume in a series of reports from a Department of Health-funded programme of work based at the Personal Social Services Research Unit at the University of Kent.

  • Other research product . Other ORP type . 2007
    Open Access English
    Authors: 
    Chataway, Jo; Chaturvedi, Kalpana; Hanlin, Rebecca; Mugwagwa, Julius; Smith, James; Wield, David;
    Publisher: ESRC Innogen Centre
    Project: WT

    Science, technology and innovation are vital to poverty alleviation and improved health. However, although improving immediate access to health care and existing health technologies is essential, simply importing technologies and products is not enough to create sustainable health care systems. Countries also need to build the capacities and institutions to develop their own technology and innovations which are tailored to local needs.\ud \ud But for innovation to meet local needs, countries need to develop dynamic and integrated health innovation systems. This is for several reasons. Firstly, there tends to be a profound lack of understanding between those in the world of healthcare and those who work in health innovation and production of pharmaceuticals. And unless researchers and producers network with local users and consumers, they are much less likely to respond to local needs.\ud \ud Secondly improved innovation capacity that responds to the needs of users does not occur in isolation - it is not the product of one-off scientific inventions, heavy investment in science or one-off policies. Rather it is dependent on networks through government institutions, private companies and a wide variety of end-user groupings at national, international and sectoral levels. Finally, knowledge is not accumulated and built up in one set of institutions and transferred to another set - it results instead from the interplay between different organisations and institutions.\ud \ud There is now an unparalleled opportunity to address both the issues of neglected diseases and to develop such integrated health innovation systems. Huge investments are currently being made in global health programmes which seek to improve health services and health innovation systems. The challenge for African policymakers is to adopt strategies for integrating global programmes with local and regional health innovation systems.

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