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  • Open Access
    Authors: 
    Susan M. Graham; Robert Carlisle; James J. Choi; Mark Stevenson; Apurva R. Shah; Rachel Myers; Kerry D. Fisher; Miriam-Bazan Peregrino; Len Seymour; Constantin C. Coussios;
    Publisher: Elsevier BV
    Country: United Kingdom
    Project: UKRI | Bubble Therapy: a New Par... (EP/F011547/1), WT | Centre of Excellence in P... (088877)

    AbstractThe encapsulation of cytotoxic drugs within liposomes enhances pharmacokinetics and allows passive accumulation within tumors. However, liposomes designed to achieve good stability during the delivery phase often have compromised activity at the target site. Thi...

  • Open Access
    Authors: 
    Gavin P. Winston; M. Jorge Cardoso; E. Williams; Jane L. Burdett; Philippa A. Bartlett; Miklos Espak; Charles Behr; John S. Duncan; Sebastien Ourselin;
    Publisher: Wiley
    Project: UKRI | Intelligent Imaging: Moti... (EP/H046410/1), UKRI | Translation of novel imag... (G0802012)

    The hippocampus is located within the medial temporal lobe and plays a key role in learning and episodic, semantic, and spatial memory. Dysfunction has been reported in neurologic and psychiatric disorders including epilepsy (Wu et al., 2005), Alzheimer's disease (Apost...

  • Open Access English
    Authors: 
    Meisenberg, Cornelia; Pinder, Sarah I; Hopkins, Suzanna R; Wooller, Sarah K; Benstead-Hume, Graeme; Pearl, Frances M G; Jeggo, Penny A; Downs, Jessica A;
    Publisher: Cell Press
    Country: United Kingdom
    Project: UKRI | Mechanistic analysis of D... (MR/N02155X/1)

    Summary Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells. Here, we identify a previously unknown role for cohesin. We fi...

  • Open Access
    Authors: 
    Petr A. Golovach; Daniël Paulusma;
    Publisher: Elsevier BV
    Country: United Kingdom
    Project: EC | PREPROCESSING (267959), UKRI | Algorithmic Aspects of Gr... (EP/G043434/1)

    A list assignment of a graph G = ( V , E ) is a function L that assigns a list L ( u ) of so-called admissible colors to each u � V . The List Coloring problem is that of testing whether a given graph G = ( V , E ) has a coloring c that respects a given list assignment ...

  • Open Access English
    Authors: 
    Henrieta Fraser; Niloufar Safinia; Nathali Grageda; Sarah Thirkell; Katie Lowe; Laura J. Fry; Cristiano Scottà; Andrew Hope; Christopher D. Fisher; Rachel Hilton; +6 more
    Publisher: American Society of Gene & Cell Therapy
    Country: United Kingdom
    Project: UKRI | MRC Centre for Transplant... (MR/J006742/1), UKRI | MRC Centre for Transplant... (MR/J006742/1)

    The concept of regulatory T cell (Treg)-based immunotherapy has enormous potential for facilitating tolerance in autoimmunity and transplantation. Clinical translation of Treg cell therapy requires production processes that satisfy the rigors of Good Manufacturing Pract...

  • Open Access English
    Authors: 
    Papanatsiou, Maria; Amtmann, Anna; Blatt, Michael R.;
    Country: United Kingdom
    Project: UKRI | 14-PSIL MAGIC: a multi-ti... (BB/M01133X/1), UKRI | Stomatal-based systems an... (BB/L001276/1)

    Stomata enable gaseous exchange between the interior of the leaf and the atmosphere through the stomatal pore. Control of the pore aperture depends on osmotic solute accumulation by, and its loss from the guard cells surrounding the pore. Stomata in most plants are sepa...

  • Open Access
    Authors: 
    Peveler, William J.; Noimark, Sacha; Al-Azawi, Hassan; Hwang, Gi Byoung; Crick, Colin R.; Allan, Elaine; Edel, Joshua B.; Ivanov, Aleksandar P.; MacRobert, Alexander J.; Parkin, Ivan P.;
    Country: United Kingdom
    Project: UKRI | DTA - University College ... (EP/M506448/1), EC | NanoPD (724300)

    The development of photoactivated antimicrobial surfaces that kill pathogens through the production of singlet oxygen has proved very effective in recent years, with applications in medical devices and hospital touch surfaces, to improve patient safety and well being. H...

  • Publication . Article . Other literature type . Preprint . 2015 . Embargo End Date: 01 Jan 2015
    Open Access
    Authors: 
    Armour, W; Hands, S; Strouthos, C;
    Publisher: arXiv
    Country: United Kingdom
    Project: UKRI | New Ideas in Gauge, Strin... (ST/L000369/1)

    Monte Carlo simulation of a 2+1 dimensional model of voltage-biased bilayer graphene, consisting of relativistic fermions with chemical potential mu coupled to charged excitations with opposite sign on each layer, has exposed non-canonical scaling of bulk observables ne...

  • Open Access
    Authors: 
    Michael Ruzhansky; Durvudkhan Suragan; Nurgissa Yessirkegenov;
    Publisher: Springer Science and Business Media LLC
    Countries: Belgium, Belgium, United Kingdom
    Project: UKRI | Quantization on Lie group... (EP/K039407/1), UKRI | Quantization on Lie group... (EP/K039407/1)

    We define Euler-Hilbert-Sobolev spaces and obtain embedding results on homogeneous groups using Euler operators, which are homogeneous differential operators of order zero. Sharp remainder terms of $L^{p}$ and weighted Sobolev type and Sobolev-Rellich inequalities on ho...

  • Open Access
    Authors: 
    Richard M. Parton; Russell S. Hamilton; Graeme Ball; Lei Yang; C. Fiona Cullen; Weiping Lu; Hiroyuki Ohkura; Ilan Davis;
    Publisher: Rockefeller University Press
    Country: United Kingdom
    Project: WT | Elucidating the molecular... (081858), UKRI | A spatio-temporally integ... (EP/F018673/1)

    Cytoskeletal organization is central to establishing cell polarity in various cellular contexts, including during messenger ribonucleic acid sorting in Drosophila melanogaster oocytes by microtubule (MT)-dependent molecular motors. However, MT organization and dynamics ...