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  • Open Access English
    Authors: 
    Emma Abernathy; Roberto Mateo; Karim Majzoub; Nicholas van Buuren; Sara W. Bird; Jan E. Carette; Karla Kirkegaard;
    Publisher: Public Library of Science
    Country: France
    Project: NIH | Subversion of Autophagy P... (1R56AI103500-01), NIH | Genetic approaches to dis... (1DP2AI104557-01)

    Author summary Viruses often co-opt host cellular processes to replicate their genomes and spread to other cells. Many of these cellular pathways provide good targets for antiviral drugs, as they are less likely to develop resistance since they are encoded in the host a...

  • Open Access English
    Authors: 
    Xue Liang; Kyle Bittinger; Xuanwen Li; Darrell R. Abernethy; Frederic D. Bushman; Garret A. FitzGerald;
    Publisher: eLife Sciences Publications, Ltd
    Project: NIH | Pilot Study: POPULATION P... (1U54HL117798-01)

    eLife digest The bacteria that inhabit the digestive tract do more than just help to break down food. Scientists are increasingly discovering that having a healthy and diverse community of gut bacteria is essential to overall health. Changes in these communities may inc...

  • Open Access
    Authors: 
    Kaiissar Mannoor; Jun Shen; Jipei Liao; Zhenqiu Liu; Feng Jiang;
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Early detection of lung c... (5I01CX000512-04), NIH | Non-invasive Biomarker Pa... (5R01CA161837-03)

    Background Non-small cell lung cancer (NSCLC) is the number one cancer killer. Tumor-initiating cells (TICs) are responsible for tumor progression and recurrence. Emerging evidences suggest that small nucleolar RNAs (snoRNAs) play malfunctioning roles in lung tumorigene...

  • Open Access English
    Authors: 
    Karen Krukowski; Austin Chou; Xi Feng; Brice Tiret; Maria-Serena Paladini; Lara-Kirstie Riparip; Myriam M. Chaumeil; Cynthia A. Lemere; Susanna Rosi;
    Publisher: MDPI AG
    Country: United States
    Project: NIH | Impact of aging on immune... (5F32AG054126-02), NIH | Generation of a Complemen... (1R21AG044713-01A1), NIH | Effects of traumatic brai... (5R21AG042016-02), NIH | UCSF-GIVI Center for AIDS... (3P30AI027763-12S2), NIH | In vivo metabolic imaging... (1R21NS096718-01), NIH | Aging exacerbates trauma-... (5R01AG056770-02)

    synapse interactions. Specifically, we found significant accumulation of C1q on synapses within the hippocampus, which was paralleled by synapse loss 30 days post injury. We used genetic and pharmacological approaches to determine the mechanistic role of complement init...

  • Open Access English
    Authors: 
    Natalia V. Barykina; Danila A. Doronin; Oksana M. Subach; Vladimir P. Sotskov; Viktor V. Plusnin; Olga A. Ivleva; Anna M. Gruzdeva; Tatiana A. Kunitsyna; Olga I. Ivashkina; Alexander A. Lazutkin; +8 more
    Publisher: Nature Publishing Group
    Project: NIH | Nitric oxide-mediated cha... (1RF1AG057705-01), NIH | Neural stem cells in the ... (7R01AG040209-05)

    Abstract The NTnC genetically encoded calcium indicator has an advantageous design because of its smaller size, GFP-like N- and C-terminal ends and two-fold reduced number of calcium binding sites compared with widely used indicators from the GCaMP family. However, NTnC...

  • Open Access English
    Authors: 
    T. David Matthews; Wolfgang Rabsch; Stanley Maloy;
    Publisher: American Society of Microbiology
    Project: NIH | Developmental Core (5U54CA132384-04), NIH | Comprehensive SDSU-UCSD C... (3U54CA132379-03S1)

    ABSTRACT Host-specific serovars of Salmonella enterica often have large-scale chromosomal rearrangements that occur by recombination between rrn operons. Two hypotheses have been proposed to explain these rearrangements: (i) replichore imbalance from horizontal gene tra...

  • Open Access English
    Authors: 
    Jana Dorfman Marcette; Jessica Jie Chen; Michael L. Nonet;
    Publisher: eLife Sciences Publications Ltd
    Project: NIH | MOLECULAR GENETIC ANALYSI... (3R01NS040094-06S1), NIH | Caenorhabditis Genetics C... (1P40OD010440-01)

    eLife digest Microtubules are tiny tubular structures made from many copies of proteins called tubulins. Microtubules have a number of important roles inside cells: they are part of the cytoskeleton that provides structural support for the cell; they help to pull chromo...

  • Publication . Article . Other literature type . 2013
    Open Access
    Authors: 
    Adriano Aguzzi; Aaron D. Gitler;
    Publisher: Elsevier BV
    Country: Switzerland
    Project: SNSF | Calcium imaging of cellul... (CRSII3_147660), NIH | Ataxin-2 as a genetic ris... (5R01NS073660-05), NIH | Using yeast cells to defi... (1DP2OD004417-01), SNSF | Chemie der Sedimentminera... (2000-004417)

    Alzheimer's disease (AD) is associated with the deposition of beta amyloid (A beta) plaques in the brain. In this issue by cleverly processing patient samples Lu et al. define a novel structural model of A beta fibrils from AD brain revealing surprising differences from...

  • Open Access English
    Authors: 
    Sujuan Guo; Kevin J. Pridham; Ching-Man A. Virbasius; Bin He; Liqing Zhang; Hanne Varmark; Michael R. Green; Zhi Sheng;
    Publisher: Nature Publishing Group
    Country: Denmark
    Project: NIH | Identification and Charac... (4R01CA163926-04)

    Dysregulated autophagy is central to the pathogenesis and therapeutic development of cancer. However, how autophagy is regulated in cancer is not well understood and genes that modulate cancer autophagy are not fully defined. To gain more insights into autophagy regulat...

  • Open Access
    Authors: 
    Kristen Hammerback; Glen Felias-Christensen; Elizabeth A. Phelan;
    Publisher: Centers for Disease Control and Prevention (CDC)
    Project: NIH | Health Promotion Research... (3U48DP000050-01S1)

    Background Lack of adequate physical activity among older adults has been widely documented. Although interventions aimed at increasing physical activity that are based on behavioral strategies and theories have been shown to increase activity levels among older adults,...