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Two high voltage direct current transmission line circuits have been simulated in the PSIM software, one employing the Individual Phase Control scheme and the other, Equidistant Pulse Control scheme. This paper presents the circuitry employed in the two simulations and the results obtained from both. It is shown that the circuit employing the former scheme suffers from an excess of non-characteristic harmonics when operating with a weak AC system whereas the latter can work on weak AC systems without problems of harmonic instability because it generates firing pulses independent of the AC source. The implementation of the two schemes clearly demonstrates how one is dependent on the feedback from the source whilst the other utilizes a Phase Locked Loop to circumvent this problem.

In recent times, the term ‘local economic development’ has been conceptualised and introduced as a bottom-up participatory development strategy in Ghana. It is intended to be implemented at the district level to facilitate the revitalisation of the local economy and create jobs for local residents. Using in-depth interviews and the analysis of relevant policy documents, this paper evaluates efforts aimed at institutionalising the practice in local institutional frameworks and development planning practice in the country. The paper found out that processes aimed at institutionalising contemporary local economic development practice in Ghana are not making any meaningful impact. Institutional frameworks such as the structuring of development policymaking and planning in the country are still rigid and promote bureaucratic top-down development decision-making processes. Similarly, the promotion of a meaningful bottom-up decentralised planning system is only a well-packaged talk by policymakers in the country. Evidence shows that there is a clear lack of political will to implement reforms, particularly the new decentralisation policy that seeks to make District Assemblies in Ghana responsive to local economic development promotion. There is the need for a conscious effort towards making local economic development practice matter in national and local development endeavour in Ghana.

Professional caregivers for cancer patients are at high risk for work-related stress, but it is not clear how this relates to exposure to death and dying, and to professional satisfaction. This study compares work-related stress and staff satisfaction on an academic acute palliative care unit (PCU) with that on a medical and radiation oncology inpatient unit (OIU) at the same cancer centre. PCU staff tended to report less work stress-particularly related to terminal care—than those on the OIU, and higher work satisfaction and team support. PCU staff were more likely to perceive their work experience as having “positively altered their attitude to death” (p=0.007). These results show that a supportive team environment can exist on an academic PCU and suggest that support currently offered to PCU staff in terms of caring for terminally ill patients should also be extended to those working in general oncology settings.

AbstractDonor lymphocyte transfusion has gained considerable interest as adoptive cellular immunotherapy for prevention or treatment of relapse after allogeneic stem cell transplantation. This study was designed to compare the yield of CD3+, CD3+4+, CD3+8+, CD19+, CD3−56+16+, and CD34+ cells contained in apheresis products from 61 consecutive non‐cytokine treated, human leukocyte antigen (HLA)‐matched donors for lymphocyte collection with the corresponding apheresis‐derived cell yield from 112 consecutive, HLA‐matched donors for blood stem cell collection who received recombinant human granulocyte colony stimulating factor (rhG‐CSF, filgrastim) 6 μg/kg every 12 hours until cell collection was completed. Apheresis was started on day 4 or 5 of rhG‐CSF treatment. The yield of lymphoid subsets was significantly different in the two sample groups, rhG‐CSF treated product yields exceeding untreated product yields by a median of 2.1‐fold (range: 1.3–2.6). However, the CD34+ cell yield in rhG‐CSF‐treated apheresis products exceeded untreated products by 26‐fold. A single untreated apheresis procedure was usually sufficient to collect a target dose of 1 × 108/kg CD3+ cells. Untreated apheresis products contained a median of 0.2 × 106/kg CD34+ cells. A potential engraftment dose of ≥0.5 × 106 CD34+ cells per kg of recipient body weight was contained in 16% of 57 untreated apheresis products. One single apheresis performed in a normal, untreated donor provides a sufficient amount of CD3+ cells for adoptive immunotherapy. Compared with that of an rhG‐CSF stimulated apheresis product, the CD34+ cell count is usually, but not always, below the engraftment dose range. RhG‐CSF treatment has little effect on the yield of lymphoid subsets collected by apheresis but is highly selective of the release of CD34+ cells. This report provides baseline data for studies that will show whether other cytokines such as granulocyte macrophage colony stimulating factor (GM‐CSF) and/or Flt‐3 Ligand can immunomodulate allotransfusates in vivo to improve the graft‐vs.‐leukemia (GVL) effect after allogeneic stem cell transplantation, while lowering the incidence and severity of graft‐vs.‐host disease (GVHD). J. Clin. Apheresis. 16:82–87, 2001. © 2001 Wiley‐Liss, Inc.