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84,455 research outcomes, page 1 of 8,446
  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Izumikawa, Keiichi; Nobe, Yuko; Ishikawa, Hideaki; Yamauchi, Yoshio; Taoka, Masato; Sato, Ko; Nakayama, Hiroshi; Simpson, Richard J; Isobe, Toshiaki; Takahashi, Nobuhiro;
    Publisher: Oxford University Press

    Abstract TDP-43 regulates cellular levels of Cajal bodies (CBs) that provide platforms for the assembly and RNA modifications of small nuclear ribonucleoproteins (snRNPs) involved in pre-mRNA splicing. Alterations in these snRNPs may be linked to pathogenesis of amyotro...

  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Jennewein, Lukas; Allert, Roman; Möllmann, Charlotte J.; Paul, Bettina; Kielland-Kaisen, Ulrikke; Raimann, Florian J.; Brüggmann, Dörthe; Louwen, Frank;
    Publisher: Public Library of Science

    Introduction: Vaginal delivery out of a breech presentation in pregnancies at term are being re-implemented into clinical practice. Still, recommendations regarding exclusion criteria leading to caesarean sections are based on expert opinions, not on evidence-based guid...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Wesley Abplanalp; Natasha DeJarnett; Daniel W. Riggs; Daniel J. Conklin; James P. McCracken; Sanjay Srivastava; Zhengzhi Xie; Shesh Rai; Aruni Bhatnagar; Timothy E. O’Toole;
    Publisher: Public Library of Science (PLoS)
    Project: NIH | American Heart Associatio... (3P50HL120163-03S1)

    Benzene is a ubiquitous, volatile pollutant present at high concentrations in toxins (e.g. tobacco smoke) known to increase cardiovascular disease (CVD) risk. Despite its prevalence, the cardiovascular effects of benzene have rarely been studied. Hence, we examined whet...

  • publication . Article . Other literature type . 2007
    Open Access
    Authors:
    Doron Betel;
    Publisher: Oxford University Press (OUP)

    MicroRNA.org (http://www.microrna.org) is a comprehensive resource of microRNA target predictions and expression profiles. Target predictions are based on a development of the miRanda algorithm which incorporates current biological knowledge on target rules and on the u...

  • publication . Book . 2019
    Open Access
    Authors:
    Häubi, Florian;
    Publisher: Schwabe Verlag

    <p>Für Nietzsche sind die metaphysischen Orientierungspunkte des menschlichen Selbstbewusstseins unter Generalverdacht geraten, ebenso wie die für ewig gehaltenen Werte, aus denen der Mensch den Glauben an seine Würde bezog. Angesichts der Unwürdigkeit des Menschen erhe...

  • publication . Other literature type . Article . 2003
    Open Access English
    Authors:
    Rebecca Wade; Dirk Walther; Razif Gabdoulline;
    Publisher: Oxford University Press

    We describe the current status of the Java molecular graphics tool, MolSurfer. MolSurfer has been designed to assist the analysis of the structures and physico-chemical properties of macromolecular interfaces. MolSurfer provides a coupled display of two-dimensional (2D)...

  • publication . Article . 2020
    Open Access
    Authors:
    Clayton B Woodcock; John R Horton; Jujun Zhou; Mark T Bedford; Robert M Blumenthal; Xing Zhang; Xiaodong Cheng;
    Publisher: Oxford University Press (OUP)

    <jats:title>Abstract</jats:title> <jats:p>The recently characterized mammalian writer (methyltransferase) and eraser (demethylase) of the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded (ss) and transiently-unpaired DNA. As YTH domain-containing proteins ...

  • publication . Article . 1996
    Open Access
    Authors:
    Lee Ann Garrett-Sinha;
    Publisher: Oxford University Press (OUP)

    In vivo transient expression and in vitro transcription experiments indicated that a segment between ‐170 and ‐40 bp upstream of the start of transcription of the mouse proα2(I) collagen gene was essential to activate transcription. DNase I protection experiments identi...

  • publication . Article . 2005
    Open Access
    Authors:
    Paul-Andre Genest; Henri van Luenen;
    Publisher: Oxford University Press (OUP)

    Attempts to inactivate an essential gene in the protozoan parasite Leishmania have often led to the generation of extra copies of the wild-type alleles of the gene. In experiments with Leishmania tarentolae set up to disrupt the gene encoding the J-binding protein 1 (JB...

  • publication . Article . 2017
    Open Access English
    Authors:
    Emily Koury; Kailey Harrell; Sarit Smolikove;
    Publisher: Oxford University Press
    Project: NIH | Caenorhabditis Genetics C... (1P40OD010440-01), NIH | An organismal approach to... (5R01GM112657-05)

    Abstract Studies of the repair pathways associated with DNA double strand breaks (DSBs) are numerous, and provide evidence for cell-cycle specific regulation of homologous recombination (HR) by the regulation of its associated proteins. Laser microirradiation is a well-...

84,455 research outcomes, page 1 of 8,446
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