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844 research outcomes, page 1 of 85
  • publication . Article . 2017
    Open Access
    Authors:
    M. Jorge Cardoso; Josephine Barnes; Frederik Barkhof; Carole Sudre;
    Publisher: Elsevier BV
    Project: EC | VPH-DARE@IT (601055), NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), RCUK | Intelligent Imaging: Moti... (EP/H046410/1), RCUK | EPICure@19 - the extremel... (MR/J01107X/1), CIHR

    To assess the relationship between carriage of APOE ε4 allele and evolution of white matter hyperintensities (WMHs) volume, we longitudinally studied 339 subjects from the Alzheimer's Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to ...

  • publication . Article . 2015
    Open Access
    Authors:
    Menezes Cordeiro Inês; von Ellenrieder Nicolas; Zazubovits Natalja; Dubeau François; Gotman Jean; Frauscher Birgit;
    Publisher: Elsevier BV
    Project: FWF | Sleep and epilepsy: contr... (J 3485), CIHR

    Summary Objective Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intra...

  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Uri Hasson;
    Publisher: The Authors. Published by Elsevier Inc.
    Project: EC | MADVIS (337573), CIHR , EC | NEUROINT (263318)

    Highlights • We examined cortical-thickness covariance networks in blind and sighted. • The two groups showed different partition structures. • In blind, occipital and lateral–temporal regions merged within modules.

  • publication . Article . Other literature type . 2014
    Open Access English
    Authors:
    Shane Harding; Robert Bristow; ELENA PETRICCI; Ermal Ismalaj; Atsushi Shibata; John Tainer;
    Publisher: Elsevier
    Project: NIH | Structural Cell Biology o... (5P01CA092584-10), NWO | The Molecular Machinery o... (2300135680), NIH | Mre11/Rad50 Structural Bi... (1R01CA117638-01), WT , CIHR

    textabstractMRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-strand break repair (DSBR), detection, and signaling; yet, how its endo- and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR) rema...

  • publication . Article . 2015
    Open Access English
    Authors:
    Eli Gibson; Yipeng Hu;
    Publisher: Elsevier
    Project: WT , CIHR

    Highlights • A novel framework for building population-predicted, subject-specific models of organ motion is presented. • Subject-specific PDFs are modelled without requiring knowledge of motion correspondence between training subjects. • A simple yet generalisable kern...

  • publication . Article . 2015
    Open Access
    Authors:
    T.K. Sham;
    Publisher: Elsevier BV
    Project: NSERC , CIHR

    Abstract This brief report reviews some of the recent findings in the study of synchrotron based X-ray excited optical luminescence (XEOL) from representative organic light emitting device (OLED) and related functional organic materials. The systems of interest include ...

  • publication . Article . 2016
    Open Access
    Authors:
    Stephen C Strother; Dawn Matthews;
    Publisher: Elsevier BV
    Project: NIH | Alzheimers Disease Neuroi... (1U01AG024904-01), NSF | SBIR Phase II: Early and ... (1256638), CIHR

    AbstractIntroductionDown Syndrome (DS) adults experience accumulation of Alzheimer's disease (AD)–like amyloid plaques and tangles and a high incidence of dementia and could provide an enriched population to study AD-targeted treatments. However, to evaluate effects of ...

  • publication . Other literature type . Article . 2014
    Open Access English
    Authors:
    Clinton Robbins; Denis ANGOULVANT; Mansoor Husain; Gerard Lambeau;
    Project: NIH | Biochemical Studies of 14... (4R37HL036235-31), CIHR

    The role of Group X secreted phospholipase A2 (GX-sPLA2) during influenza infection has not been previously investigated. We examined the role of (Reviewer 2 Minor Comment 2) GX-sPLA2 during H1N1 pandemic influenza infection in a GX-sPLA2 gene targeted mouse (GX−/−) mod...

  • publication . Other literature type . Article . 2015
    Open Access English
    Authors:
    James H. Frederich;
    Project: CIHR

    We have discovered a fragment of the natural product roseophilin, a member of the prodiginine family, that antagonizes Mcl-1 functions in a liposome-based assay for mitochondrial membrane permeabilization. By tailoring this substance such that it can participate in salt...

  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Lotta von Boehmer; Andrew McGuire; Marit J. van Gils; Thiago Y Oliveira; Pia Dosenovic;
    Publisher: Elsevier
    Project: EC | SHEV (280829), CIHR

    A subset of individuals infected with human immunodeficiency virus 1 (HIV-1) develops broadly neutralizing antibodies (bNAbs) that can prevent infection, but it has not yet been possible to elicit these antibodies by immunization. To systematically explore how immunizat...

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