Abstract: This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β142, tau, and phosphorylated tau in the diagnostic evaluation of ...

Present adress of Olivier Micheau: INSERM U517, Faculties of Medicine and Pharmacy, 7 Bd Jeanne d'Arc, 21033 Dijon Cedex, France; International audience; Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the adaptor FADD and caspase-8 ...

Summary Background Rhizaria are a major branch of eukaryote evolution with an extensive microfossil record, but only scarce molecular data are available. The rhizarian species Reticulomyxa filosa , belonging to the Foraminifera, is free-living in freshwater environments...

The vascular and the nervous system are responsible for oxygen, nutrient, and information transfer and thereby constitute highly important communication systems in higher organisms. These functional similarities are reflected at the anatomical, cellular, and molecular l...

Stent thrombosis (ST) has been a shortcoming of coronary artery stents since their inception. However, the advent of dual antiplatelet therapy (DAPT), improved stent platforms, and emphasis on optimal stent implantation have led to event rates of 1% to 2% in contemporar...

AbstractMultiple signaling pathways regulate proliferation and differentiation of neural progenitor cells during early development of the central nervous system (CNS). In the spinal cord, dorsal signaling by bone morphogenic protein (BMP) acts primarily as a patterning ...

AbstractA transition in hemoglobin behavior at close to body temperature has been discovered recently by micropipette aspiration experiments on single red blood cells (RBCs) and circular dichroism spectroscopy on hemoglobin solutions. The transition temperature was dire...

We consider the extreme values of fractional Brownian motions, self-similar Gaussian processes and more general Gaussian processes which have a trend -ct[beta] for some constants c,[beta]>0 and a variance t2H. We derive the tail behaviour of these extremes and show that...